La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.
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We bring the most advanced assays and testing methods to our pharmaceutical and biotechnology clients. Our comprehensive test menu includes markers of efficacy, exposure, response and susceptibility.
Targeting specific disease states and readily identifying clinical responses are of critical importance in clinical trials. At ICON Central Laboratories, our Scientific Affairs staff carefully reviews the latest professional literature and commercially available test kits to select methods with the greatest sensitivity and specificity. In addition, we work closely with sponsors facing special challenges, such as drug interference or specimen stability, to find quality solutions. Our scientists are recognized in the industry for their willingness to collaborate with study sponsors who need custom developed and validated assays for their clinical studies
As a global leader in providing central laboratory services, we utilize identical testing platforms and methods to ensure accurate, consistent test results and reference ranges.
This brochure lists our most frequently requested biomarkers. For more information about our custom assay development services or additional testing capabilities that may not appear in this listing, please contact your ICON Central Laboratories Business Development representative.
ICON Central Laboratories’ Scientific Affairs Department carefully reviews the latest professional literature and test kits to select those with the greatest sensitivity and specificity. In addition, we work closely with sponsors facing special challenges, such as drug interference or specimen stability, to find custom, quality solutions.
Because ICON Central Laboratories is a global provider of central laboratory services and uses identical testing platforms and methods worldwide, we can assure study sponsors of accurate, consistent biomarker test results.
ICON Central Laboratories currently offers biomarkers for the following indications:
Adrenal/Pituitary Disorders BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Autoimmune Disease BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Bone Disease BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Cardiac Markers BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Hemostasis/Angiogenesis BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Infectious Disease BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Inflammation / Immune - Status / Cell Response BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Lipid Metabolism BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Metabolic Markers BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Pulmonary Function BIOMARKER ANALYTICAL METHOD(S) Renal Function BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Reproductive Endocrinology BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Thyroid Function BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) Tumor Markers BIOMARKER ANALYTICAL METHOD(S) BIOMARKER ANALYTICAL METHOD(S) For more information regarding biomarkers or other central laboratory services, please contact: North America
Email: labinfo@iconplc.com www.icolabs.com
Antonino NICOLETTI ASSISTANT PROFESSOR IN CELL BIOLOGY AND IMMUNOLOGY EDUCATION & PROFESSIONNAL EXPERIENCE 1995 Doctorate in Aging Biology (Ph.D.), University Paris VII - Laboratory of Human Immunopathology, INSERM U430, Paris, France Myocardial fibrosis in experimental hypertension: role of hormonal and inflammatory factors Post-Doctoral training at the Karolinska Inst
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We bring the most advanced assays and testing methods to our pharmaceutical and biotechnology clients. Our comprehensive test menu includes markers of efficacy, exposure, response and susceptibility.