Microsoft word - cv_en an oct 2007.rtf
Antonino NICOLETTI
ASSISTANT PROFESSOR IN CELL BIOLOGY AND IMMUNOLOGY
EDUCATION & PROFESSIONNAL EXPERIENCE
1995
Doctorate in Aging Biology (Ph.D.), University Paris VII - Laboratory of Human
Immunopathology, INSERM U430, Paris, France
Myocardial fibrosis in experimental hypertension: role of hormonal and inflammatory factors
Post-Doctoral training at the Karolinska Institute, Stockholm, Sweden - 2 year grant from the
European Union’s "Training and Mobility for Researchers" program
Mechanism of autoimmunity in atherosclerosis
Assistant Professor at the Paris VI University - Research activity in the INSERM U430, of the
UMRS 681 and of the Tema 16 UMRS872 (CRC), Paris, France
Function and modulation of specific immunity in atherosclerosis
HDR : “Habilitation à Diriger des Recherches” - Paris VI University
TEACHING DUTIES
I perform my teaching duties (>250 h/year) at the University Pierre et Marie Curie (Paris 6) in ‘Immunology’
(section CNU 65) for the undergraduate and post graduate students. The syllabus includes fol owing courses :
Immune tolerance workshop (principal coordinator
Immunopathophysiology (principal coordinator)
Advanced flow cytometry workshop (principal
METHODS & TECHNICS
In vivo and
in vitro gene transfer by Adherent (vascular cel s) and non-
flow cytometry; Cel proliferation; Cytokine production ; In vivo biophotonic imaging
method for col agen by polarized light microscopy
ORGANIZATIONAL ACTIVITIES
• Since I joined the UMRS681, I lead the group working on the modulation of the immune response as a
therapeutic tool in vascular pathologies. This group is composed of a CR1 INSERM researcher, a ‘research engineer’ from the University of Paris 6, and an INSERM research technician. We are supervising 4 students (3 PhD and 1 master’s student). Since 1998, I have supervised 1 post-doc fel ow (B Poirier), 4 PhD students (E Tupin, O Thaunat, A Varthaman, E Groyer), and 3 master’s students (M Vandaele, E Laurat, A Gadzinski)
• Since 2003, I have been a jury member for 15 PhD thesis defense • I am an elected member of the scientific council of the Centre de Recherche des Cordeliers and a member of
the steering committee of the central animal facility and of the Internet and the Intranet facilities of the campus
• I am an active member of the regional ethical committee for animal experimentation (CREEA Ile de France
• Member of the organizing committee of the French Science Festival • Co-organizer of an international symposium entitled ‘Infl ammation, an unexpected guest in chronic diseases?’
(Centre de Recherche des Cordeliers, Sept 2006)
MISCELLANEOUS
• Reviewer for Circulation, Atherosclerosis, Thrombosis and Vascular Biology, The Journal of Experimental
• Invited speaker at the symposium of the Journal of Internal Medicine (Stockholm, Octobre 2007). • I have obtained several research grants including the Claude Bernard foundation, ‘La Fondation de France’. I
have been serving as a co-PI for research projects supported by public and private granting agencies such as Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, CSL-Behring, LFB, Bayer, Octapharma
• Fluent in English and Italian • Expert in informatics and creator of the web site of the unit • Co-inventor of the patent “Atherosclerosis vaccine”. Hansson GK, Wutgge D, Stemme S, Nicoletti A. - Patent
PCT/SE01/00570 - june 2000. This patent is based on the identification of the T cel epitopes of oxidized LDL and relies on the use of a vaccinal strategy to treat atherosclerosis
PUBLICATIONS
1. Thaunat O., Louedec L., Graff-Dubois S., Dai J., Groyer E.,
8. Thaunat O., Louedec L., Dai J., Bellier F., Groyer E.,
Yacoub-Youssef H., Mandet C., Bruneval P., Kaveri S.,
Delignat S., Gaston A. T., Caligiuri G., Joly E.,
Caligiuri G., Germain S., Michel J. B., and Nicoletti A. In
Plissonnier D., Michel J. B., and Nicoletti A. 2006. Direct
press. Anti-angiogenic treatment prevents adventitial
and Indirect Effects of Alloantibodies Link Neointimal and
Transplantation.
Arterioscler Thromb Vasc Biol 26:2359-2365.
2. Thaunat O., Patey N., Michel J. B., and Nicoletti A. 2007. Is
9. Thaunat O., Kerjaschki D., and Nicoletti A. 2006. Is
lymphoid neogenesis a therapeutic target for chronic
defective lymphatic drainage a trigger for lymphoid
rejection?
Am J Transplant 7:1312-1313.
neogenesis?
Trends Immunol 27:441-445.
3. Monteiro M., Evaristo C., Legrand A., Nicoletti A., and
10.Thaunat O., Field A. C., Michel J. B., and Nicoletti A.
Rocha B. 2007. Cartography of gene expression in CD8
2006. [Implication of the lymphoid neogenesis process in
single cells: novel CCR7- subsets suggest differentiation
chronic rejection.].
Med Sci (Paris) 22:110-111.
independent of CD45RA expression.
Blood 109:2863-
11.Khallou-Laschet J., Tupin E., Caligiuri G., Poirier B.,
Thieblemont N., Gaston A. T., Vandaele M., Bleton J.,
4. Michel J. B., Thaunat O., Houard X., Meilhac O., Caligiuri
Tchapla A., Kaveri S. V., Rudling M., and Nicoletti A.
G., and Nicoletti A. 2007. Topological determinants and
consequences of adventitial responses to arterial wall
apolipoprotein E knockout mice.
Atherosclerosis
injury.
Arterioscler Thromb Vasc Biol 27:1259-1268.
5. Groyer E., Nicoletti A., Ait-Oufella H., Khallou-Laschet J.,
12.Khallou-Laschet J., Caligiuri G., Groyer E., Tupin E.,
Varthaman A., Gaston A. T., Thaunat O., Kaveri S. V.,
Gaston A. T., Poirier B., Kronenberg M., Cohen J. L.,
Blatny R., Stockinger H., Mallat Z., and Caligiuri G. 2007.
Klatzmann D., Kaveri S. V., and Nicoletti A. 2006. The
Atheroprotective effect of CD31 receptor globulin through
proatherogenic role of T cells requires cell division and is
enrichment of circulating regulatory T-cells.
J Am Coll
dependent on the stage of the disease.
Arterioscler
Cardiol 50:344-350.
Thromb Vasc Biol 26:353-358.
6. Caligiuri G., Khallou-Laschet J., Vandaele M., Gaston A.
13.Groyer E., Caligiuri G., Laschet-Khallou J., and Nicoletti
T., Delignat S., Mandet C., Kohler H. V., Kaveri S. V., and
A. 2006. [Immunological aspects of atherosclerosis].
Presse Med 35:475-486.
immunization reduces atherosclerosis.
J Am Coll Cardiol 14.Duong Van Huyen J. P., Delignat S., Bayry J.,
Kazatchkine M. D., Bruneval P., Nicoletti A., and Kaveri
7. Thaunat O., Patey N., Morelon E., Michel J. B., and
S. V. 2006. Interleukin-12 is associated with the in vivo
Nicoletti A. 2006. Lymphoid neogenesis in chronic
anti-tumor effect of mistletoe extracts in B16 mouse
rejection: the murderer is in the house.
Curr Opin
melanoma.
Cancer Lett.
Immunol 18:576-579.
15.Demigne C., Bloch-Faure M., Picard N., Sabboh H.,
cells in the blood of atherosclerotic mice with plaque
Besson C., Remesy C., Geoffroy V., Gaston A. T., Nicoletti
thrombosis.
Arterioscler Thromb Vasc Biol 25:1659-
A., Hagege A., Menard J., and Meneton P. 2006. Mice
chronically fed a westernized experimental diet as a model
27.Tupin E., Nicoletti A., Elhage R., Rudling M., Ljunggren
of obesity, metabolic syndrome and osteoporosis.
H. G., Hansson G. K., and Berne G. P. 2004. CD1d-
European journal of nutrition 45:298-306.
dependent activation of NKT cells aggravates
16.Caligiuri G., Rossignol P., Julia P., Groyer E., Mouradian
atherosclerosis.
J Exp Med 199:417-422.
D., Urbain D., Misra N., Ollivier V., Sapoval M., Boutouyrie
28.Tupin E., Poirier B., Bureau M. F., Khallou-Laschet J.,
P., Kaveri S. V., Nicoletti A., and Lafont A. 2006. Reduced
Vranckx R., Caligiuri G., Gaston A. T., Duong Van
immunoregulatory CD31+ T cells in patients with
Huyen J. P., Scherman D., Bariety J., Michel J. B., and
atherosclerotic abdominal aortic aneurysm.
Arterioscler
Nicoletti A. 2003. Non-viral gene transfer of murine
Thromb Vasc Biol 26:618-623.
spleen cells achieved by in vivo electroporation.
Gene
17.Caligiuri G., Kaveri S. V., and Nicoletti A. 2006. IL-20 and
Ther 10:569-579.
atherosclerosis: another brick in the wall.
Arterioscler 29.Nicoletti A., and Caligiuri G. 2003. Les lymphocytes et
Thromb Vasc Biol 26:1929-1930.
18.Bayary J., Dasgupta S., Misra N., Ephrem A., Duong Van
Huyen J. P., Delignat S., Hassan G., Caligiuri G., Nicoletti
thérapeutiques. J. F. Toussaint, M. P. Jacob, L. Lagrost,
A., Lacroix-Desmazes S., Kazatchkine M. D., and Kaveri S.
and J. Chapman, eds. Masson, Paris. 112-146.
2006. Intravenous immunoglobulin in autoimmune
30.Kohler H., Bayry J., Nicoletti A., and Kaveri S. V. 2003.
disorders: An insight into the immunoregulatory
Natural autoantibodies as tools to predict the outcome of
mechanisms.
Int Immunopharmacol 6:528-534.
immune response?
Scand J Immunol 58:285-289.
19.Thaunat O., Field A. C., Dai J., Louedec L., Patey N.,
31.Gervais M., Pons S., Nicoletti A., Cosson C., Giudicelli J.
Bloch M. F., Mandet C., Belair M. F., Bruneval P., Meilhac
F., and Richer C. 2003. Fluvastatin prevents renal
O., Bellon B., Joly E., Michel J. B., and Nicoletti A. 2005.
dysfunction and vascular NO deficit in apolipoprotein E-
Lymphoid neogenesis in chronic rejection: evidence for a
deficient mice.
Arterioscler Thromb Vasc Biol 23:183-
local humoral alloimmune response.
Proc Natl Acad Sci U
S A 102:14723-14728.
32.Gaertner R., Lepailleur-Enouf D., Gonzalez W., Nicoletti
20.Thaunat O., Caligiuri G., Nicoletti A., and Michel J. B.
A., Mandet C., Philippe M., Mercadier J. J., and Michel J.
2005. Complexity of antigenic determinants and humoral
B. 2003. Pulmonary endothelium as a site of synthesis
responses in vascular injury.
Cardiovasc Res 68:183-185.
and storage of interleukin-6 in experimental congestive
21.Persson L., Borén J., Nicoletti A., Hansson G. K., and
heart failure.
Eur J Heart Fail 5:435-442.
Pekna M. 2005. Immunoglobulin treatment reduces
33.Caligiuri G., Stahl D., Kaveri S., Irinopoulous T., Savoie
atherosclerosis in apolipoprotein E–/– low-density
F., Mandet C., Vandaele M., Kazatchkine M. D., Michel
lipoprotein receptor–/– mice via the complement system.
J. B., and Nicoletti A. 2003. Autoreactive antibody
Clin Exp Immunol 142:441-445.
repertoire is perturbed in atherosclerotic patients.
Lab
22.Misra N., Bayry J., Ephrem A., Dasgupta S., Delignat S.,
Invest 83:939-947.
Van Huyen J. P., Prost F., Lacroix-Desmazes S., Nicoletti
34.Caligiuri G., Rudling M., Ollivier V., Jacob M. P., Michel
A., Kazatchkine M. D., and Kaveri S. V. 2005. Intravenous
J. B., Hansson G. K., and Nicoletti A. 2003. Interleukin-
immunoglobulin in neurological disorders: a mechanistic
10 deficiency increases atherosclerosis, thrombosis, and
perspective.
J Neurol 252 Suppl 1:I1-6.
low-density lipoproteins in apolipoprotein E knockout
23.Misra N., Bayary J., Dasgupta S., Ephrem A., Huyen J. P.,
mice.
Mol Med 9:10-17.
Delignat S., Hassan G., Caligiuri G., Nicoletti A., Lacroix-
35.Kuo C. C., Campbell L. A., Rosenfeld M. E., Caligiuri G.,
Desmazes S., Kazatchkine M. D., and Kaveri S. V. 2005.
Rottenberg M., Wigzell H., Hansson G. K., and Nicoletti
Intravenous immunoglobulin and dendritic cells.
Clinical
A. 2002. Chlamydia pneumoniae infection and
reviews in allergy & immunology 29:201-205.
24.Khallou-Laschet J., Caligiuri G., Tupin E., Gaston A. T.,
response.
Circulation 105:34.
Poirier B., Groyer E., Urbain D., Maisnier-Patin S., Sarkar
36.Fournier N., Cogny A., Atger V., Pastier D.,
R., Kaveri S. V., Lacroix-Desmazes S., and Nicoletti A.
Goudouneche D., Nicoletti A., Moatti N., Chambaz J.,
2005. Role of the intrinsic coagulation pathway in
Paul J. L., and Kalopissis A. D. 2002. Opposite effects of
atherogenesis assessed in hemophilic apolipoprotein E
plasma from human ApoA-II transgenic mice on
knockout mice.
Arterioscler Thromb Vasc Biol 25:e123-
cholesterol efflux from J774 macrophages and Fu5AH
hepatoma cells.
Arterioscler Thromb Vasc Biol
25.Caligiuri G., Kaveri S., and Nicoletti A. 2005. When
interleukin-18 conducts, the Preludio sounds the same no
37.Duong Van Huyen J. D., Bayry J., Delignat S., Gaston A.
matter who plays.
Arterioscler Thromb Vasc Biol 25:655-
T., Michel O., Bruneval P., Kazatchkine M. D., Nicoletti
A., and Kaveri S. 2002. Induction of apoptosis of
26.Caligiuri G., Groyer E., Khallou-Laschet J., Al Haj Zen A.,
endothelial cells by Viscum album: A role for anti-tumoral
Sainz J., Urbain D., Gaston A. T., Lemitre M., Nicoletti A.,
properties of mistletoe lectins.
Mol Med 8:600-606.
and Lafont A. 2005. Reduced immunoregulatory CD31+ T
38.Caligiuri G., Nicoletti A., Poirier B., and Hansson G. K.
2002. Protective immunity against atherosclerosis carried
52.Caligiuri G., Nicoletti A., Zhou X., Tornberg I., and
by B cells of hypercholesterolemic mice.
J. Clin. Invest.
Hansson G. K. 1999. Effects of sex and age on
atherosclerosis and autoimmunity in apoE- deficient
39.Bruneval P., Bariety J., Belair M. F., Mandet C., Heudes
mice.
Atherosclerosis 145:301-308.
D., and Nicoletti A. 2002. Mesangial expansion associated
53.Nicoletti A., and Sassy-Prigent C. 1998. Alternative
with glomerular endothelial cell activation and macrophage
quantitative PCR method. In
Gene cloning and analysis
recruitment is developing in hyperlipidaemic apoE null
by RT-PCR. P. B. Siebert, and J. W. Larrick, eds. Eaton
mice.
Nephrol Dial Transplant 17:2099-2107.
40.Laurat E., Poirier B., Tupin E., Caligiuri G., Hansson G. K.,
54.Nicoletti A., Kaveri S., Caligiuri G., Bariety J., and
Bariety J., and Nicoletti A. 2001. In vivo downregulation of
Hansson G. K. 1998. Immunoglobulin treatment reduces
T helper cell 1 immune responses reduces atherogenesis
atherosclerosis in apo E knockout mice.
J Clin Invest
in apolipoprotein E-knockout mice.
Circulation 104:197-
55.Nicoletti A., and Sassy-Prigent C. 1996. An alternative
41.Caligiuri G., Rottenberg M., Nicoletti A., Wigzell H., and
quantitative polymerase chain reaction method.
Hansson G. K. 2001. Chlamydia pneumoniae infection
Analytical biochemistry 236:229-241.
does not induce or modify atherosclerosis in mice.
56.Nicoletti A., Mandet C., Challah M., Bariety J., and
Circulation 103:2834-2838.
Michel J. B. 1996. Mediators of perivascular
42.Zhou X., Nicoletti A., Elhage R., and Hansson G. K. 2000.
inflammation in the left ventricle of renovascular
Transfer of CD4(+) T cells aggravates atherosclerosis in
hypertensive rats.
Cardiovasc Res 31:585-595.
mice.
57.Nicoletti A., Heudes D., Mandet C., Hinglais N., Bariety
Circulation 102:2919-2922.
J., and Michel J. B. 1996. Inflammatory cells and
43.Pueyo M. E., Gonzalez W., Nicoletti A., Savoie F., Arnal J.
myocardial fibrosis: spatial and temporal distribution in
F., and Michel J. B. 2000. Angiotensin II stimulates
renovascular hypertensive rats.
Cardiovasc Res
endothelial vascular cell adhesion molecule-1 via nuclear
factor-kappaB activation induced by intracellular oxidative
58.Zhuang Y. F., Corone-Alden S., Duval A. M., Benvenuti
stress.
Arterioscler Thromb Vasc Biol 20:645-651.
C., Albo C., Deleuze P., Loisance D., Benhayem N.,
44.Nicoletti A., Paulsson G., Caligiuri G., and Hansson G. K.
Heudes D., Nicoletti A., and et al. 1995. Right ventricular
2000. Induction of neonatal tolerance to oxidized-LDL
late filling termination time and its relation to interstitial
reduces atherosclerosis susceptibility in apoE knockout
collagen content in early transplanted heart: a color M-
mice.
Mol Med 6:283-290.
mode Doppler digital analysis.
J Heart Lung Transplant
45.Nicoletti A., Caligiuri G., and Hansson G. K. 2000.
Immunomodulation of atherosclerosis: myth and reality.
J 59.Nicoletti A., Heudes D., Hinglais N., Appay M. D.,
Intern Med 247:397-405.
Philippe M., Sassy-Prigent C., Bariety J., and Michel J.
46.Caligiuri G., Paulsson G., Nicoletti A., Maseri A., and
B. 1995. Left ventricular fibrosis in renovascular
Hansson G. K. 2000. Evidence for antigen-driven T-cell
hypertensive rats. Effect of losartan and spironolactone.
response in unstable angina.
Circulation 102:1114-1119.
Hypertension 26:101-111.
47.Caligiuri G., and Nicoletti A. 2000. Origines infectieuses de
60.Michel J. B., Nicoletti A., and Arnal J. F. 1995. Left
l'athérosclérose.
Médecine et thérapeutiques 6:593-597.
myocardial infarction.
Eur Heart J 16:49-57.
48.Nicoletti A., and Michel J. B. 1999. Cardiac fibrosis and
inflammation: interaction with hemodynamic and hormonal
61.Challah M., Nicoletti A., Arnal J. F., Philippe M.,
factors.
Cardiovasc Res 41:532-543.
Laboulandine I., Allegrini J., Alhenc-Gelas F., Danilov S., and Michel J. B. 1995. Cardiac angiotensin converting
49.Nicoletti A., Caligiuri G., Tornberg I., Kodama T., Stemme
enzyme overproduction indicates interstitial activation in
S., and Hansson G. K. 1999. The macrophage scavenger
renovascular hypertension.
Cardiovasc Res 30:231-
receptor type A directs modified proteins to antigen
presentation.
Eur J Immunol 29:512-521.
62.Michel J. B., Hinglais N., Nicoletti A., and Arnal J. F.
50.Nicoletti A., Caligiuri G., Paulsson G., and Hansson G. K.
1994. Remodelage ventriculaire et collagène cardiaque.
1999. Functionality of specific immunity in atherosclerosis.
In
Approche biologique de l'insuffisance cardiaque.
Am Heart J 138:438-443.
51.Mouthon L., Nicoletti A., Lacroix-Desmazes S., Kaveri S.,
63.Hinglais N., Heudes D., Nicoletti A., Mandet C., Laurent
and Kazatchkine M. D. 1999. Mécanismes d'action des
M., Bariety J., and Michel J. B. 1994. Colocalization of
immunoglobulines intraveineuses (IgIV).
Sang Thrombose
myocardial fibrosis and inflammatory cells in rats.
Lab
Vaisseaux 11:52-59.
Invest 70:286-294.
Source: http://www.crcjussieu.fr/crc/upload/cv/47203073da75d_MBR_CV_EN_AN_oct_2007.pdf
Chapter 13 ________________________________________________________________________ Quality of life impairment in bipolar disorder Erin E Michalak1, Greg Murray2, Allan H Young1 and Raymond W Lam1 1Department of Psychiatry, University of British Columbia 2Faculty of Life and Social Sciences, Swinburne University of Technology This chapter will present an overview of what is currently
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