European NanOSH Conference – Nanotechnologies: A Critical Area in Occupational Safety and Health 3–5 December 2007, Marina Congress Center, Helsinki, Finland
Scientific Programme Sunday, 2 December 2007
Registration and information desk open at the lobby of the hotel Grand Marina Scandic (address: Katajanokanlaituri 7, Helsinki)
18.30–20.00 Get-together at hotel Grand Marina Scandic, Commodore room (address: Katajanokanlaituri 7, Helsinki) Monday, 3 December 2007 8.00–17.00 Registration and information desk open at Marina Congress Center (address: Katajanokanlaituri 6, Helsinki)
Opening Place: Fennia II, Marina Congress Center (address: Katajanokanlaituri 6, Helsinki) Chair: Harri Vainio, Finland Opening address Representative of Finnish Government
Address of an international organisation Speaker to be announced later Address of the European Chemical Agency (ECHA) Dr Geert Dancet, Interim Executive Director of ECHA, European Commission
Address of the Organization for Economic Co-operation and Development (OECD) Dr Mar Gonzalez,Administrator Environment, Health and Safety Division, Environment Directorate, OECD Address of ISPESL – National Institute for Occupational Safety and Prevention, Italy Professor Antonio Moccaldi, President of ISPESL, Italy 10.30–11.00 COFFEE/TEA BREAK Opening keynote Place: Fennia II, Marina Congress Center Chair: Harri Vainio, Finland
11.00 Emerging global safety issues of nanotechnologies – Future challenges Andrew Maynard, Woodrow Wilson International Centre for Scholars, USA
12.00–13.30 LUNCH Plenary I: Tackling with the safety of nanotechnologies today – National and global approaches Place: Fennia II, Marina Congress Center Chairs: Sergio Iavicoli, Italy, and Ruth Duncan, United Kingdom 13.30 Global approaches and possible solutions to face nanotechnology safety challenges Ruth Duncan, Cardiff University, United Kingdom Tackling with future nanotechnology challenges in Europe Pilar Aguar, Directorate General for Research, European Commission Research strategy on safety of nanotechnologies in Japan-Introduction of NEDO project (2006-2010) entitled ‘Evaluating Risks Associated with Manufactured Nanomaterials’ Toshihiko Myojo, University of Occupational and Environmental Health, Japan 15.00–15.30 COFFEE/TEA BREAK
15.30 Current occupational safety and health issues of nanotechnology in USA Paul Schulte, National Institute for Occupational Safety and Health, USA Promotion of safety of nanotechnologies in Finland jointly with the industry – Progress and challenges Tuomas Raivio, Gaia Consulting Ltd, Finland 16.30 Estimating occupational exposure to nanoparticles: Gaps and needs Sergio Iavicoli, ISPESL– National Institute for Occupational Safety and Prevention, Italy
19.00–20.30 HELSINKI CITY RECEPTION at Helsinki City Hall (address: Pohjoisesplanadi 11-13, Helsinki)
Hoast: Mrs Paula Kokkonen, Deputy Mayor for Social Affairs and Public Health, City of Helsinki
Tuesday, 4 December 2007 8.00–17.00 Registration and information desk open Plenary II: Tackling with the scientific challenges of nanotechnology to solve workplace health hazards
Place: Fennia II, Marina Congress Center
Chairs: Anna A. Shvedova, USA, and Kaarle Hämeri, Finland
9.00 Efforts by the Japanese National Institute of Health Science to develop measures to evaluate the health effects of manufactured nanomaterials Akihiko Hirose, National Institute of Health Science, Japan
9.30 Occupational exposure to nanoparticles and risks associated with nanotechnology at workplace Vincent Castranova, National Institute for Occupational Safety and Health, USA 10.00 Carbon NanoBuds (CNBTM) and Single Walled NanoTubes (SWCNT) – Synthesis, structure and properties Esko I. Kauppinen, Nanomaterials Group, Laboratory of Physics & Center for New Materials, Helsinki University of Technology & VTT Biotechnologyy, Finland
10.30 Facing the key workplace challenge: Assessing and preventing exposure to nanoparticles at source Kaarle Hämeri, Finnish Institute of Occupational Health, Finland
11.00–11.30 COFFEE/TEA BREAK
11.30 Toxicity of single walled carbon nanotubes in vivo: Relevance to occupational exposures Anna A. Shvedova, National Institute for Occupational Safety and Health, USA 12.00 Brain and Heart: Key targets of nanoparticles? Wolfgang Kreyling, GSF - National Research Center for Environment and Health, Germany 12.30–13.30 LUNCH
13.30–14.30 Poster session Venue: Nordia, Marina Congress Center 1. In vitro assessment of genotoxicity of Co nanoparticles and ions: Influence of chemistry and of biological variability on genotoxic endpoints Bergamaschi E, Bonelli A, Farina M, Sabbioni E, Migliore L, Italy 2. A novel and simple dispersing technique for carbon nanotubes that can be used for in vivo and in vitro studies Elgrabli D, Abella-Gallart S, Aguerre-Charriol O, Robidel F, Rogerieux F, Boczkowski J, 3. Genotoxicity of titanium dioxide in vitro Falck GC-M, Lindberg HK, Suhonen S, Vippola M, Vanhala E, Savolainen K, Norppa H, Finland 4. Personal exposure of a tile worker to nanopollution and contamination of his partner: A case report. Gatti AM, Gambarelli A, Montanari S, Ferri C, Giuggioli D, Italy 5. Industrial and environmental not-engineered nanopollution and its impact on human health. Gatti AM, Gambarelli A, Montanari S, Italy 6. Cross sectional study on respiratory effect of toner exposed work in manufacturing plants, Japan – Pulmonary function, blood cells and biochemical markers Kitamura H, Terunuma N, Kurosaki S, Hata K, Kuga H, Kakiuchi N, Masuda M, Yoshizumi K, Morimoto Y, Kasai H, Higashi T, Murase T, Japan 7. Respiratory morbidity and exposure to toner dust: A cross-sectional study on toner manufacturing and service workers in a Japanese company – Pulmonary functions, blood cells and biochemical markers Matsushita T, Kuga T, Kitamura H, Terunuma N, Nakamoto K, Kakiuchi N, Kurosaki S, Hata K, Masuda M, Yoshizumi K, Higashi T, Japan 8. Experimental set-up for inhalation exposure of mice to nanosized TiO2 Mäkinen M, Miettinen M, Jokiniemi J, Joutsensaari J, Korpi A, Pasanen P, Finland 9. Regulatory implications of the research into and the risk assessment of nanomaterials 10. Safety assessment of azelaic acid and its derivatives entrapped in nanovesicles Panyosak A, Manosroi J, Rojanasakul Y, Manosroi A, Thailand 11. Acute changes of cardiovascular autonomic regulation induced by single-wall carbon nanotubes in rats: An original experimental model Pietroiusti A, Magrini A, Legramante J M, Palleschi G, Moscone D, Valentini F, Sacco S, Galante A, Bergamaschi E, Bottini M, Bergamaschi A, Italy 12. Acute effects of aerosol exposure of titanium dioxide on airway inflamation in Rossi E, Pylkkänen L, Nykäsenoja H, Wolff H, Alenius H, Savolainen K, Finland 13. Cross sectional study on respiratory effect of toner exposed work in manufacturing plants, Japan – Subjective respiratory symptoms, incidence of respiratory disease using questionnaire and findings in chest roentgenogram Terunuma N, Kitamura H, Kuga H, Kurosaki S, Kakiuchi N, Masuda M, Hata K, Yoshizumi K, Morimoto Y, Kasai H, Higashi T, Murase T, Japan 14. Nanotechnology and Occupational Health in Russia Tkach AV, Tkacheva TA, Russian Federation 15. NANOKEM: Dust from nanoparticle-containing paints: Exposure assessment and toxicological properties Vogel U, Schneider T, Jensen K A, Stoltenberg M, Hougaard KS, Larsen ST, Loft S, Möller P, Wallin H, Denmark 16. Biogenic generated nano-sized particles in the ozone-limonene system: Bioassay testing and hydroxyl radical potential Wolkoff P, Clausen PA, Nørgaard AW, Larsen K, Denmark 17. Genotoxicity of nanosized titanium dioxide in human lymphocytes in vitro Hannukainen K, Lindberg HK, Falck GC-M, Järventaus H, Vippola M, Vanhala E, 18. Genotoxicity of carbon nanomaterials in vitro Lindberg HK, Falck GC-M, Suhonen S, Vippola M, Vanhala E, Savolainen K, Norppa H, Finland 19. Exploring the feasiblity to use a structured observational method to assess dermal exposure to engineered nanoparticles (ENPs): Results from NANOSH pilot studies Brouwer D, Hertsenberg S, Moehlmann C, Berges M, Wake D, Mark D, the Netherlands 20. Chemical and dimensional characterization of nanoparticles in the evaluation of professional exposure Castellano P, Ferrante R, Canepari S, Astolfi M L, Italy 21. Risk assessment model of occupational exposure to nanomaterials 22. Portable low cost airborne particle size distribution spectrometer for exposure/dose evaluation Gnewuch HWJ, Gorbunov B, Muir RB, United Kingdom 23. Information & training N@NORISK website Sicard Y, Tardif C, Tardif F, France 24. Emission of nanoparticles in the process of developing new polymers Jankowska E, Zatorski W, Posniak M, Poland 25. Characterizing surface-area of airborne nanostructured particles Bau S, Witschger O, Gensdarmes F, Thomas D, France 26. Measurement of particle characteristics at seven Swedish plants 27. Determination of backbone chain directions of PDA using FFM 28. Production and characterization of engineered titanium dioxide nanoparticles for in vitro and in vivo toxicity tests. Koivisto J, Alenius H, Hämeri K, Jokiniemi J, Joutsensaari J, Norppa H, Miettinen M, Pasanen P, Pylkkänen L, Rossi E, Tuomi T, Vippola M, Finland 29. Synthesis of TiO2 nanoparticles for the studies of their health effects Miettinen MA, Suonmaa V, Tapper U, Backman U, Joutsensaari J, Auvinen A, Jokiniemi 30. Volatile emissions from gas-phase oxidation of carbon nanotubes and fullerenes by ozone and nitrate radicals Nøjgaard JK, Clausen PA, Wolkoff P, Denmark 31. Effect of dispersing media on nanoparticles reactivity Sauvain J-J, Deslarzes S, Riediker M, Switzerland 32. Generation of appropriate nanoparticle dispersions for genotoxicity testing Vippola M, Falck G, Lindberg H, Suhonen S, Vanhala E, Norppa H, Tuomi T, Tossavainen 33. Nanoparticle characterization protocol for occupational exposure and health Vippola M, Bard D, Burdett G, Vanhala E, Tuomi T, Mark D, Tossavainen A, Finland Session 1a: Toxicity and health effects of nanoparticles (theme continues after the break, parallel Place: Fennia II, Marina Congress Center Chair: to be announced later
14.30 Self-reported repiratory symptoms and exposure to toner dust: A cross sectional study on toner manufacturing and service workers in a Japanese company. Kuga H, Matsushita T, Kitamura H, Terunuma N, Nakamoto K, Kakiuchi N, Kurosaki S, Hata K, Masuda M, Yoshizumi K, Higashi T, Japan
14.45 Effects of nano-sized titanium dioxide exposure on allergic asthma Pylkkänen L, Rossi E, Leino M, Wolff H, Savolainen K, Alenius H, Finland Carbon black and diesel exhaust particles are mutagenic in the FE1-Muta™Mouse lung epithelial cell line. Single-walled carbon nanotubes and fullerenes (C60) are not. Jacobsen NR, Møller P, Saber AT, Cohn C, White P, Pojana G, Korsholm K, Vogel U, Loft S, Wallin H, Denmark NanoImpactNet – European Network on the Health and Environmental Impact of Nanomaterials Riediker M, Switzerland Session 2: Exposure to and control of nanoparticles (Parallel to session 1a) Place: Fennia I, Marina Congress Center Chair: Timo Tuomi, Finland
14.30 NANOPLAST: Nano-technological materials and products in the plastics industry: Exposure assessment and toxicological properties Clausen PA, Vogel U, Høg Lejre A-L, Bøgelund J, Jensen KA, Nørgaard AW, Nøjgaard J K, Schneider T, Cohn C, Saber AT, Møller P, Loft S, Wallin H, Wolkoff P, Denmark
14.45 Health risk, exposure and bioavailability of lead nanoparticles at working places Gorbunov B, Muir R, Priest ND, Jackson P, United Kingdom Aerosol dynamics of NP in workplace exposure Seipenbusch M, Binder A, Kasper G, Grimm H, Wu Q, Germany Experimental evaluation of individual devices against nanoaerosols: Fibrous filter media, cartridge for respirators, protective clothing and gloves Bernard ST, Tardif F, Rouillon F, Guiot A, Golanski L, France
15.30-16.00 Coffee/tea break Session 1b: Toxicity and health effects of nanoparticles (theme continues from before the break, Place: Fennia II, Marina Congress Center 16.00 Toxicity of nanoparticles versus 3T3 cells Gatti AM, Sighinolfi G, Quaglino D, Tossini D, Italy
16.15 Impact of physico-chemical characteristics on in vitro toxicity of oxide nanoparticles and carbon nanotubes Simon A, Reynaud C, Mayne M, Herlin N, Desqueroux H, Gouget B, Carriere M, France
16.30 Carbon nanotubes affect the barrier function of human epithelial cells in vitro Bergamaschi E, Rotoli BM, Bianchi MG, Bellucci S, Magrini A , Bussolati O, Italy
16.45 Genotoxic effects of nanomaterials Norppa H, Falck GC-M, Lindberg HK, Suhonen S, Savolainen K, Finland Session 3: Nanoparticle characteristics (Parallel to session 1b)
Place: Fennia I, Marina Congress Center
Chair: Pertti Pasanen, Finland
16.00 An alternative method to BET method for estimating off-line the specific surface area of nanostructured particles Bau S, Witschger O, Gensdarmes F, Thomas D, Rastoix O, France
16.15 Metal and metal oxide nanoparticle generation by liquid flame spray for instrument testing and exposure studies Mäkelä JM, Aromaa M, Keskinen H, Rostedt A, Marjamäki M, Keskinen J, Finland
16.30 Selection of metrics relevant for inhalation health risk study of nanoparticle aerosols Wu Q, Seipenbusch M, Kasper G, Grimm H, Weitzenböck J, Norway
16.45 Nanoparticle monitor based on escaping-current technology (ECT) Janka K, Ukkonen A, Nokkonen E, Reinivaara R, Niemelä V, Finland approx. 19.00 Busses from hotels to the dinner (please, check the bus schedule) 19.30–22.00 CONFERENCE DINNER at Restaurant Pörssi, Helsinki (address: Fabianinkatu 14,
Wednesday, 5 December 2007 8.00–15.00 Registration and information desk open Plenary III: Risk management and control technology
Place: Fennia II, Marina Congress Center Chairs: Kai Savolainen, Finland, and Ellen Silbergeld, USA 8.30 Nanomaterial health effects research contributes to risk management strategies through the risk assessment paradigm Kevin Dreher, Pulmonary Toxicology Branch, Environmental Protection Agency, USA
9.00 Looking as we leap: Prudent risk assessment for nanotechnologies Ellen Silbergeld, Johns Hopkins University, Bloomberg School of Public Health, USA
9.30 Control technologies to prevent exposure to nanoparticles Markus Berges, BG- Institute for Occupational Safety and Health, Germany
10.00 Managing nanotechnology risks to workers: Integration of health and safety into the workplace Dave Mark, Health and Safety Laboratory, United Kingdom
10.30–11.00 COFFEE/TEA BREAK 11.30 Metal and mataloxide nanoparticles and their properties in workplace air Jorma Jokiniemi, VTT Technical Research Centre of Finland, Finland 12.00 Assessing inhalation exposure to nanoaerosols in the workplace Olivier Witschger, Laboratoire de Métrologie des Aérosols, INRS – Centre de Lorraine, France 12.30 Integrating safety into nanomaterial production – Key to success Jacques Ragot, Bayer MaterialScience AG, Germany Risk communication with regard to nanotechnology and nanomaterials Virginia Sublet, National Institute for Occupational Safety and Health, USA Closing Conclusions and closing Kai Savolainen, Finnish Institute of Occupational Health, Finland
CCES Canadian Centre for Ethics in Sport Be true to yourself. Be true to your sport. Centre canadien pour l’éthique dans le sport Respecter son sport, c’est se respecter soi-même. 202-2197 promenade Riverside Drive, Ottawa, Ontario K1H 7X3 Canada Tel./Tél. 613.521.3340 Fax/Téléc. 613.521.3134 InfoLine 1.800.672.7775 Autorisation d’usage à des fins thérapeutiques : Proces
74 Prince, A.M. et al. (1992) J. Infect. Dis. 165, 438–443 78 Laskus, T. et al. (1996) Virology 220, 171–176 75 Farci, P. et al. (1992) Science 258, 135–140 79 Cane, E.J. et al. (1996) New Engl. J. Med. 334, 815–820 76 Martell, M. et al. (1994) J. Virol. 68, 3425–3436 80 Okamoto, H. et al. (1994) Hepatology 20, 1131–1136 77 Gretch, D.R. et a