Microsoft word - central centrifugal cicatricial alopecia _ccca_.docx

Central centrifugal cicatricial alopecia (CCCA)
Candrice R. Heath, MD, Caroline N. Robinson, BS and Roopal V. Kundu, MD

Central centrifugal cicatricial alopecia (CCCA) is a very common cause of
alopecia (hair loss) among African-American women. Hair loss from
CCCA occurs primarily in the central (crown) part of the scalp. The hair
loss radiates outward in a centrifugal or circular pattern and is usually gradual although some people experience a rapid progression of the hair loss. CCCA causes destruction of the hair follicles and scarring leading to permanent hair loss. CCCA is the most common type of cicatricial (scarring) alopecia.1
What is the cause of CCCA?
The exact cause of CCCA is unknown. Though previously thought to be
solely related to the use of hot combs, excessive heat and hot oils on the
scalp, chemical relaxers, and excessive tension from braids, tight hair rollers, weaves or extensions, the current thought also points to heredity (family history) playing a role.1-2 When scalp samples (biopsies) from people affected by CCCA are examined under a microscope, inflammation and scarring is typically present around the hair follicles.1-2

How do I know if I have CCCA?

Symptoms of CCCA can vary and may include itching, burning, tingling,
pain or no symptoms at all. Dermatologists typically suspect this condition by examining your scalp, but many will take a small sample from the scalp (a biopsy) and send it to the lab for evaluation and confirmation of the diagnosis. What treatments are available for CCCA?
It is best to treat CCCA early before permanent hair loss develops. As
the disease progresses, hair follicles may scar beyond the point of repair.
The mainstay of treatment is anti-inflammatory medications. Topical,
oral, or injected corticosteroids, oral antibiotics, and other anti-inflammatory agents may help reduce inflammation and prevent hair loss.1-2 Minoxidil may also be used to help stimulate hair growth from follicles that are not scarred. Gentle hair grooming practices such as natural (chemical and heat-free) hair styles, reduced frequency of relaxers, and limited styling products, are also recommended in order to prevent inflammation and concomitant hair breakage.2 Hair transplantation may be considered in patients with permanent hair loss in whom scalp inflammation is absent or well controlled.2 Studies are
needed to help better define this disorder and effective treatments.
Additional Resources:
Cicatricial Alopecia Research Foundation,

1. Quinn, CR. Alopecia. In: Kelly AP, Taylor SC, editors. Dermatology for Skin of  Color. New York: McGraw Hill Medical; 2009. p.227‐239.  2. Callendar VD and Young CM. Alopecias and hair restoration in women. In:  Aesthetics and Cosmetic Surgery for Darker Skin Types. Philadelphia: Lippincott Williams and Wilkins;  2008. P. 287‐295. 



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Microsoft word - cv_en an oct 2007.rtf

Antonino NICOLETTI ASSISTANT PROFESSOR IN CELL BIOLOGY AND IMMUNOLOGY EDUCATION & PROFESSIONNAL EXPERIENCE 1995 Doctorate in Aging Biology (Ph.D.), University Paris VII - Laboratory of Human Immunopathology, INSERM U430, Paris, France Myocardial fibrosis in experimental hypertension: role of hormonal and inflammatory factors Post-Doctoral training at the Karolinska Inst

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