La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.

Pa id

AARP MedicareRx Preferred (PDP) plan
STEP THERAPY ALGORITHMS
Treatment Group
Description
Step 1: Metformin

Step 2: Actoplus Met
Step 1: Metformin

Step 2: Actos
Step 1: One of the following:

Step 2: Amitiza
Step 1: One of the following Tier 1 or Tier 2 antidepressants:
a. SSRI b. SNRI c. Bupropion d. Mirtazepine
Step 2: Emsam
Step 1: Fomepizole 1 gm/mL injection (generic)
Step 2: Antizol 1 gm/mL injection (brand)
Step 1: Pamidronate disodium injection (generic)
Step 2: Aredia 30 mg or Aredia 90 mg injection (brand)
Treatment Group
Description
Step 1: Metformin

Step 2: Avandamet
Step 1: Metformin

Step 2: Avandaryl
Step 1: Metformin

Step 2: Avandia
Step 1: One Tier 1 or Tier 2 bisphosphonate

Step 2: Fosamax Oral Solution
Step 1: Irinotecan 20 mg/mL injection (generic)
Step 2: Camptosar 20 mg/mL injection (brand)
Step 1: Ofloxacin otic

Step 2: Cetraxal
Step 1: One of the following sulfonylurea products:
a. Glyburide b. Glipizide c. Glimepiride
Step 2: Diabinese (chlorpropamide)
Step 1: One of the following:
b. Dextroamphetamine c. Dexmethylphenidate d. Methylphenidate
Step 2: Strattera
Step 1: Colistimethate sodium 150 mg injection (generic)
Step 2: Coly-Mycin 150 mg injection
Treatment Group
Description
Step 1: Dihydroergotamine mesylate 1 mg/mL injection (generic)
Step 2: D.H.E. 1 mg/mL injection (brand)
Step 1: Desmopressin acetate 4 mcg/mL injection (generic)

Step 2: DDAVP 4 mcg/mL injection (brand)
Dipeptidyl Peptidase-4 Inhibitor Therapy Step 1: Metformin

Step 2: Januvia or Onglyza
Dipeptidyl Peptidase-4 Inhibitor/ Metformin Step 1: Metformin
Step 2: Janumet
Step 1: Metformin

Step 2: Duetact
Step 1: Epirubicin Injection (generic)
Step 2: Ellence Injection (brand)
Step 1: Amifostine Injection (generic)
Step 2: Ethyol Injection (brand)
Step 1: One of the following atypical antipsychotics:
a. Geodon b. Risperidone c. Seroquel/Seroquel Step 2: Fanapt
Step 1: Idarubicin injection (generic)

Step 2: Idamycin PFS injection (brand)
Step 1: Metformin

Step 2: Byetta
Treatment Group
Description
Step 1: One Tier 1 or Tier 2 inhaled corticosteroid
Step 2: Aerobid, Aerobid-M, Asmanex, Azmacort, or Alvesco
Step 1: One of the following atypical antipsychotics:
Step 2: Invega
Step 1: Singulair

Step 2: Accolate or Zyflo CR
Step 1: One of the following:

Step 2: Foradil or Serevent
Step 1: One of the following formulary opioid products

Step 2: Demerol (meperidine)
Step 1: Morphine sulfate ER (generic)
Step 2: MS Contin 200 mg (brand)
Step 1: Pentostatin injection (generic)
Step 1: Nipent injection (brand)
Novantrone injection Novantrone Therapy* Step 1: Mitoxantrone 2 mg/mL injection (generic)
Step 2: Novantrone 2 mg/mL injection (brand)
Treatment Group
Description
Step 1: One of the following:

Step 2: Xalatan
Step 1: Nortriptyline capsules
Step 2: Pamelor capsules
Step 1: One of the following formulary opioid products:
a. Hydrocodone b. Methadone c. Morphine d. Oxycodone e. Opiate/acetaminophen
Step 2: Talwin NX (pentazocine/ naloxone) or Talacen (pentazocine/ acetaminophen)
Step 1: One of the following:
b. Beta-blocker c. Calcium-channel blocker
Step 2: Ranexa
Step 1: One of the following:

Step 2: Selfemra
Step 1: Sumatriptan injection

Step 2: Sumavel
Treatment Group
Description
Step 1: One of the following:
c. Angiotensin II receptor blocker d. Angiotensin II receptor blocker combination
Step 2: Tekturna or Tekturna HCT
Step 1: Topical Corticosteroid

Step 2: Elidel or Protopic
Step 1: Allopurinol

Step 2: Uloric
Step 1: Albuterol (nebulizer)

Step 2: Xopenex Nebulizer
Step 1: Ondansetron Injection (generic)
Step 2: Zofran Injection (brand)

*Step therapy applies to new starts only

Source: http://www.q1medicare.com/2011/content/includes/pdpPlanMaterials/AARP-2011_PDP_StepTherapyCriteria_Preferred.pdf