La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.
Microsoft word - dr.abdi cv.doc
Curriculum Vitae Azadeh Abdi Address: 3th floor, block 7, Kashani boulevard, Hamedan, Iran Telephone Number : 0988118380572 Mobile: azadeh @ abdi . umsha ac . ir . ------ draabdi@ com . yahoo - E mail: Personal Information Date of Birth: 07/02/1979 Place of Birth: Mashhad Nationality: Iranian Marital status: single Identity Card No. : 87 National Code: 094-089232-4 Professional Experience 23/09/2003 - 22/11/2007 Work as a pharmacist supervisor in some private pharmacies 25/05/2006-28/07/2006 Work as a researcher in project "morphine exposure during pregnancy and breast feeding can affect anti-inflammatory,analgesia,tolerance and dependency responses to morphine in rat neonates" in Neuroscience Research Center, Shaheed Beheshti University of medical sciences 12/01/2006 - 29/09/2009 working on my thesis Apoptosis Inhibition Can Be Threatening in A -induced Neuroinflammation, Through Promoting Cell Proliferation 16/09/2008 5/11/2008 Work in darsavin pars Co., as a pharmacist and researcher in R&D Department 15/11/2008 29/10/2009 work in Genian Daru co. in scientific committee ( quality assurance) 7/11/2009 - 15/7/2010 work as a researcher on two projects in karolinska institute, Sweden. And graduated in Ph.D of pharmacology from Shahid Beheshti University of medical science 1/12/2010 till now teaching pharmacology for medical student in Hamedan university of medical science Subjects which I am teaching : drugs used in Central nervous system disorders: Introduction to the Pharmacology of CNS Drugs Sedative-Hypnotic Drugs Antidepressant Agents Antiseizure Drugs Parkinsonism Antipsychotic Agents & Lithium Opioid analgesics Skeletal Muscle Relaxants Local Anesthetics General Anesthetics Drugs used in gastrointestinal disorders Drugs used in asthma Drugs used in anemia Anti coagulant and coagulant agents Drugs used as chemotherapy Autonomic system introduction to autonomic system Cholinergic agents Anticholinergic agents Adrenergic agents Antiadrenergic agents Drugs used in endocrinology disorders Pancreatic Hormones & Antidiabetic Drugs Thyroid and Antithyroid Drugs The Gonadal Hormones Adrenocorticosterons Agents Affecting Bone Mineral Homeostasis Educational Background 2003 - 2009 PhD student in Pharmacology in Shaheed Beheshti University of Medical Sciences, Pharmacology Department, Tehran, Iran 1997 - 2002 Doctorate Degree in Pharmacy, Mashhad University of Medical Sciences, Pharmacy Faculty, Mashhad, Iran Publications Articles: 1. Apoptosis Inhibition Can Be Threatening in A -induced Neuroinflammation, Through Promoting Cell Proliferation. A. Abdi , H. Sadraie¶, L. Dargahi , L. Khalaj , A. Ahmadiani *. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Pharmacology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ¶ Department of Anatomy,School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. Neuro chem Res (2011) 36:39 48 2. A quantitative assay for monitoring of autophagosome formation in cells depending on the phase of the cell cycle. Kaminskyy V, Abdi A, Zhivotovsky B. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institute, Box 210, SE-171 77 Stockholm, Sweden. Autophagy 2011 , 7:1, 83-90 3. Alginate protects NT2 neurons against H2O2-induced neurotoxicity. Bahareh Eftekharzadeha, Fariba Khodagholi, Azadeh Abdia and Nader Maghsoudi, Carbohydrate polymeras, 2010,79(4):1063-1072. 4. Protective effects of lycopen and tomato extract against Doxorubicin-induced cardiotoxicity. Gholamreza Karimia*, Mohammad Ramezanib, Azadeh Abdia, Phytotrapy Reaserch,2005,19:912-914 5.Spinal Ischemic-Reperfusion Injury Protection by Acute Estradiol Administration in Male Rabbits.Leila Khalaj, Habibollah Peirovi, Fariba Khaodagholi, Azadeh Abdi, Leila Dargahi, fatemeh mohagheghi and abolhassan Ahmadiani*. the Journal of physiology and pharmacology ,Iranian society of physiology and pharmacology,2010, 14(1):1-11. 6.Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in A -Induced Neuroinflammation. Leila Dargahi , Shiva Nasiraei-Moghadam ,Azadeh Abdi , Leila Khalaj , Fatemeh Moradi ,Abolhassan Ahmadiani, J Mol Neurosci. 7.Dietary supplementation with tBHQ, an Nrf2 stabilizer molecule,confers neuroprotection against apoptosis in amyloid -injected rat. F.Nouhi, SK.Tusi, A.Abdi, F. Khodagholi, Neurochem Res, 8. Acute 17 -Estradiol pretreatment protects against abdominal aortic occlusion induced spinal cord Ischemic-Reperfusion injury. Leila Khalaj1, Habibollah Peirovi2, Fariba Khodagholi1, Azadeh Abdi1, Leila Dargahi1,Abolhassan Ahmadiani1, Neurochem Res. 9. Caspase inhibition in neuroinflammation induced by soluble amyloid monomer, protects cells from abnormal survival and proliferation, via attenuation of NF B activity. Azadeh Abdi , Fatemeh Mohagheghi , Homayoon Sadraei , Leila Dargahi , Leila Khalaj and Abolhassan Ahmadiani ,Iranian society of physiology and pharmacology, 2010, 14(3): 211-219. Presentations: Cancer therapy and apoptosis Apoptosis and signaling pathways Alzheimer disease, pathology and recommended treatment Nicotinic acetylcholine receptors and the regulation of neuronal signaling Absorbtion and distribution 6 hours teaching pharmacology in Shahid Beheshti medical university to medical students Teaching pharmacology to medical students and all medical science majors in hamedan university of medical science science 2o1o Congresses: 1- Mashhad Pharmaceutical congress, Iran, 2000. 2- Kerman pharmaceutical congress, Kerman, Iran, 2001. 3- First international symposium on molecular technology and apoptosis 30th July- 1th August 2005. 4- Second international symposium on molecular technology and apoptosis 26th-27th June 2007. 5- Iranian congress of Pharmacology and physiology, Mashhad, Iran, 2007. 6- 19th Iranian congress of physiology and pharmacology, Tehran, Iran, 2009 7- Nobel symposium NO: 144, the cell cycle and apoptosis in disease, 23-26 may 2010, Karolinska institute, Stockholm, Sweden. 8- 20th Iranian Congress of Pharmacology and Physiology, Hamedan, Iran, 2011. Languages Persian : native language English : good Techniques Western blotting Electrophoresis(SDS-PAGE) TUNEL PCR Immunocytochemistry (ICC) Immuno peresipitation (IP) Flowcytometry Cerebroventricular cannulation Spinal cord cannulation Rat perfusion with fixator Stereotaxis surgery Protein extraction Cellular fractionation Protein assay: brad ford and BCA Tail flic test Peltismometery test Rat handling Cell culture Confocal microscopy Gene transfection Knocking down gene Hot plate Some behavioral techniques for evaluating sciatic index : extensor postural thrust (EPT), statistic sciatic index (SSI) Work shops : Teaching techniques 2011 Methods for publishing articles 11th Jun 2012 Referees - pro.Abolhassan Ahmadiani , Neuroscience Research Center and Pharmacology department , Shaheed Beheshti University of Medical Sciences and Health Services , Evin , Tehran , Iran -pro.Nader maghsudi, Neuroscience Research Center , Shaheed Beheshti University of Medical Sciences and Health Services , Evin , Tehran , Iran - Prof. Fereshteh Motamedi , Neuroscience Research Center , Shaheed Beheshti University of Medical Sciences and Health Services , Evin , Tehran , Iran Prof. Boris Zhivotovsky , The Institute of Environmental Medicine, Karolinska Institutet,Stockholm, Sweden.
Curriculum Vitae