Microsoft word - leaflet sj_005_201131128_delcastillo_2012-01-17.doc
Antioxidant product derived from coffee residues CSIC has developed a procedure for the extraction of antioxidant compounds from coffee silverskin, a residue of roasted coffee beans. The method involves an extraction step with water and the extracts contain high amounts of bioactive compounds such as chlorogenic acid and caffeine, with applications in cosmetics, food and health. Industrial partners interested in the development and commercialisation of this technology, are An offer for Patent Licensing Valorisation of a by-product of the coffee industry
The procedure consists on the extraction of the coffee silverskin (the
only by-product of coffee roasting) without prior milling, by using
subcritical water at moderate temperature (50ºC or higher) and high
pressure (1500 psi), although unpressurized water at 100ºC can be used too. Under these conditions, extracts with high antioxidant properties
are obtained in 10-20 min, with antioxidant activity depending on the extraction conditions: 0.85 – 3,7 g of equivalents of chlorogenic acid and 150 – 450 mg of caffeine, both per 100 mg of silverskin, when extracted
with only hot water or under subcritical conditions, respectively. The extracts, following lyophilisation, are stable at room temperature
for more than 6 months, making them highly suitable for its use as
antioxidants. Moreover, they keep its antioxidant activity after in vitro
gastrointestinal digestion, which broadens its potential applications as
functional ingredients. Finally, the extract can be used directly as a cosmetics ingredient, facilitating a pH closer to than of the skin.
Main applications and advantages
• Exploitation of a by-product of industrial processing of coffee
Patent Status
beans, widely available and which disposal is an environmental
• Use of an environmental friendly, low-cost method that avoids
using organic solvents, using instead subcritical water, allowing
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• Energy and time-saving and simplification of procedure, since it is
applied to the whole coffee silverskin without previous grinding.
Thus, the extraction is more effective, as caking occurring with
• The extract is rich in bioactive components surviving
gastrointestinal digestion process and remaining bioavailable to
• It maintains the antioxidant properties for more than 6 months at
• It can be used as antioxidant food additive and in the manufacture
of cosmetics, with potential functions of excipient (preservative,
flavouring) and activity (antioxidant, anti-ageing, anti-cellulite)
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Medicamento controlado Composición Cada comprimido de liberación prolongada de Buprión ® SR 150 contiene: Bupropión clorhidrato. 150 mg Excipientes .c.s. Propiedades Farmacodinámicas: el bupropión actúa a nivel del sistema nervioso central inhibiendo en forma selectiva la recaptación de catecolaminas (noradrenalina y dopamina) con efectos mínimos sobre la recaptación de serot