La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.

Lsr antibiotic profile 2012

2012 ANTIBIOTIC SUSCEPTIBILITY PROFILES
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Number of Isolates 1963
PENICILLIN
FLUCLOXACILLIN
AMOXYCILLIN
AMOX / CLAV
CEFACLOR
COTRIMOXAZOLE
ERYTHROMYCIN
CLINDAMYCIN
TETRACYCLINE
GENTAMICIN
CIPROFLOXACIN
NITROFURANTOIN
TRIMETHOPRIM
The percentage of organisms susceptible to an antibiotic is recorded (with the sample size in the first column of the table). (e.g. Staphylococcus aureus vs. flucloxacillin 86% susceptible, n=1963) S = Not specifically tested, but known to be ordinarily susceptible. R = Organism resistant or antibiotic inappropriate. a. S. aureus susceptible to flucloxacillin can be considered susceptible to amoxycillin-clavulanate and cefaclor. Methicillin resistant Staphylococcus aureus (i.e. MRSA) are resistant to all beta-lactam antibiotics (penicillins, cephalosporins, carbapenems). b. Clindamycin susceptibility is extrapolated from the erythromycin result. c. S. pneumoniae susceptible to penicillin can be considered susceptible to amoxycillin, amoxycillin-clavulanate, cefaclor, cefuroxime, cefotaxime, ceftriaxone, cefpodoxime, imipenem and meropenem. Confirmation of penicillin resistance (reduced susceptibility) in S. pneumoniae requires MIC testing. (Please note this figure includes both susceptible and intermediately susceptible isolates). S.pneumoniae isolates intermediately susceptible to penicillin are resistant to cefaclor. In 2012 our S. pneumoniae isolates demonstrated the following pattern of susceptibility to penicillin: 85% = Susceptible, 4% = Intermediate, 11% = Resistant. However, of the resistant strains only a few had a penicillin MIC > 4mg/L, and penicillins (amoxycillin) are effective against strains with MIC <= 4mg/L, unless they are causing meningitis. d. Susceptibility is extrapolated from an indicator beta lactam result. e. Erythromycin is not recommended for treatment of infections thought to be due to H. influenzae. f. S. saprophyticus causing urinary tract infections will usually respond to amoxycillin-clavulanate and cephalosporins. (Up to 50% of isolates are g. Cotrimoxazole susceptibility is extrapolated from the trimethoprim result. h. Derived from nalidixic acid result. MOST LIKELY BACTERIAL PATHOGENS IN COMMON CONDITIONS 1. RESPIRATORY INFECTIONS
2. URINARY TRACT INFECTION
Pharyngitis - Streptococcus pyogenes (Gp A 3. IMPETIGO / CELLULITIS
Acute exacerbation of Chronic Bronchitis Haemophilus influenzae Moraxella catarrhalis

Source: http://www.lsr.net.nz/PicsHotel/PathLab/Brochure/LSR%20Antibiotic%20profile%202012.pdf