Microsoft word - artemisinin literature.doc

ARTEMISININ-COMPOUNDS LITERATURE LIST (2/05)
(cancer-related papers are marked with an asterisk *)

Abdin MZ, Israr M, Rehman RU, Jain SK. Artemisinin, a novel antimalarial drug:
biochemical and molecular approaches for enhanced production. Planta Med 69(4):289-
299, 2003.
Ai J, Gao HH, He SZ, Wang L, Luo DL, Yang BF. Effects of matrine, artemisinin, and
tetrandrine on cytosolic [Ca2+]I in guinea pig ventricular myocytes. Acta Pharmacol Sin
22:512-515, 2001.
Akintonwa DA.Theoretical mechanistic basis of the toxic effects and efficacy of AZT in
HIV: AIDS. Med Hypotheses 59(6):622-625, 2002.
Akompong T, VanWye J, Ghori N, Haldar K: Artemisinin and its derivatives are
transported by a vacuolar-network of Plasmodium falciparum and their anti-malarial
activities are additive with toxic sphingolipid analogues that block the network. Mol
Biochem Parasitol. 101(1-2):71-79, 1999.
Akompong T, Eksi S, Williamson K, Haldar K: Gametocytocidal activity and synergistic
interactions of riboflavin with standard antimalarial drugs against growth of Plasmodium
falciparum in vitro. Antimicrob Agents Chemother. 44(11):3107-3111, 2000.
Aldieri E, Atragene D, Bergandi L, Riganti C, Costamagna C, Bosia A, Ghigo D:
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.
FEBS Lett 552(2-3):141-144, 2003.
Alin MH, Bjorkman A, Landberg-Lindgren A, Ashton M: The effect of artemisinin, its
derivatives and mefloquine against chloroquine-resistant strains of Plasmodium
falciparum in vitro. Trans R Soc Trop Med Hyg 86:365-397, 1992.
Alin MH, Kihamia CM, Bjorkman A, Bwijo BA, Premji Z, Mtey GJB, Ashton M:
Efficacy of oral and intravenous artesunate in male Tanzanian adults with Plasmodium
falciparum malaria and in vitro susceptibility to artemisinin, chloroquine, and
mefloquine. Am J Trop Med Hyg 53:639-645, 1995.
Alin MH, Ashton M, Kihamia CM, Mtey GJB, Bjorkman A: Clinical efficacy and
pharmacokinetics of artemisinin monotherapy and in combination with mefloquine in
patients with falciparum malaria. Br J Clin Pharmacol 41:587-592, 1996.
Alin MH, Ashton M, Kihamia CM, Mtey GJB, Bjorkman A: Multiple dose
pharmacokinetics or oral artemisinin and comparison of its efficacy with that of oral
artesunate in falciparum malaria patients. Trans R Soc Trop Med Hyg 90:61-65, 1996.
Arnold K: Early treatment of malaria in the community using artemisinin- hope or
hazard? Trans R Soc Trop Med Hyg 88 (supp 1):S1/47-S/49, 1994.
Asawamahasakda W, Benakis A, Meshnick SR: The interaction of artemisinin with red cell membranes. J Lab Clin Med 123:757-762, 1994. Asawamahasakda W, Ittarat I, Chang CC, McElroy P, Meshnick SR: Effects of antimalarials and protease inhibitors on plasmodial hemozoin production. Mol Biochem Parasitol 67:183-191, 1994. Asawamahasakda W, Ittarat I, Pu YM, Ziffer H, Meshnick SR: Reaction of antimalarial endoperoxides with specific parasite proteins. Antimicrob Agents Chemother 38:1854-1858, 1994. Ashton M, Gordi T, Hai TN, Huong NV, Sy ND, Nieu NT, Huong DX, Johansson M, Cong LD: Artemisinin pharmacokinetics in healthy adults after 250, 500 and 1000 mg single oral doses. Biopharm Drug Dispos 19:245-250, 1998. Ashton M, Hai TN, Sy ND, Huong DX, Huong NV, Nieu NT, Cong LD: Artemisinin pharmacokinetics is time-dependent during repeated oral administration in healthy male adults. Drug Metab Dispos 26:25-27, 1998. Ashton M, Johansson L, Thornqvist AS, Svensson USH: Quantitative in vivo and in vitro sex differences in artemisinin metabolism in rat. Xenobiotica 29:195-204, 1999. Ashton M, Sy ND, Huong NV, Gordi T, Hai TN, Huong DX, Nieu NT, Cong LD: Artemisinin kinetics and dynamics during oral and rectal treatment of uncomplicated malaria. Clin Pharmacol Ther 63:482-493, 1998. Augustijns P, D’Hulst A, Van Daele J, Kinget R: Transport of artemisinin and sodium artesunate in Caco-2 intestinal epithelial cells. J Pharmaceut Sci 85:577-579, 1996. Avery BA, Venkatesh KK, Avery MA: Rapid determination of artemisinin and related analogues using high-performance liquid chromatography and an evaporative light scattering detector. J Chromatogr B: Biomed Sci Appl 730:71-80, 1999. Avery MA, Muraleedharan KM, Desai PV, Bandyopadhyaya AK, Furtado MM, Tekwani BL: Structures-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria. J Med Chem 46(20):4244-4258, 2003. Bachi MD, Korshin EE, Hoos R, Szpilman AM, Ploypradith P, Xie S, Shapiro TA, Posner GH: A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides. J Med Chem 46(12):2516-2533, 2003. Bachi MD, Korshin EE, Ploypradith P, Cumming JN, Xie S, Shapiro TA, Posner GH: Synthesis and in vitro antimalarial activity of sulfone endoperoxides. Bioorg Med Chem Lett 8:903-908, 1998. Bachi MD, Korshin EE, Hoos R, Szpilman AM, Ploypradith P, Xie S, Shapiro TA, Posner GH. A Short Synthesis and Biological Evaluation of Potent and Nontoxic Antimalarial Bridged Bicyclic beta-Sulfonyl-Endoperoxides. J Med Chem 46(12):2516-2533, 2003. Bakhshi HB, Gordi T, Ashton M: In-vitro interaction of artemisinin with intact human erythrocytes, erythrocyte ghosts, haemoglobin and carbonic anhydrase. J Pharm Pharmacol 49:223-226, 1997. Balint GA: Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmac Therapeut 90:261-265, 2001. Bapiro TE, Andersson TB, Otter C, Hasler JA, Masimirembwa CM: Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol 58(8):537-542, 2002. Batty KT, Ashton M, Ilett KF, Edwards G, Davis TME: The pharmacokinetics of artemisinin (ART) and artesunate (ARTS) in healthy volunteers. Am J Trop Med Hyg 58:125-126, 1998. Batty KT, Ilett KF, Davis TME: Chemical stability of artesunate injection and proposal for its administration by intravenous infusion. J Pharm Pharmacol 48:22-26, 1996. Batty KT, Davis TME, Thu LTA, Binh TQ, Anh TK, Ilett KF: Selective high-performance liquid chromatographic determination of artesunate and α- and β-dihydroartemisinin in patients with falciparum malaria. J Chromatogr B: Biomed Appl 677:345-350, 1996. Batty KT, Ilett KF, Edwards G, Powell SM, Maggs JL, Park BK, Davis TME: Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes. Br J Pharmacol 125:159-167, 1998. Batty KT, Thu LTA, Ilett KF, Tien NP, Powell SM, Hung NC, Mai TX, Chon VV, Thien HV, Binh TQ, Kim NV, Davis TME: A pharmacokinetic and pharmacodynamic study of artesunate for vivax malaria. Am J Trop Med Hyg 59:823-827, 1998. Batty KT, Thu LTA, Davis TME, Ilett KF, Mai TX, Hung NC, Tien NP, Powell SM, Thien HV, Binh TQ, Kim NV: A pharmacokinetic and pharmacodynamic study of intravenous vs oral artesunate in uncomplicated falciparum malaria. Br J Clin Pharmacol 45:123-129, 1998. Batty KT, Iletr KE, Powell SM, Martin J, Davis TM. Relative bioavailability of artesunate and dihydroartemisinin: investigations in the isolated perfused rat liver and in healthy Caucasian volunteers. Am J Trop Med Hyg 66(2):130-136, 2002. *Beekman AC, Barentsen AR, Woerdenbag HJ, Uden WV, Pras N, Konings AWT, El-Feraly FS, Galal AM, Wikstrom HV: Stereochemistry-dependent cytotoxicity of some artemisinin derivatives. J Nat Prod 60:325-330, 1997. *Beekman AC, Wierenga PK, Woerdenbag HJ, Uden WV, Pras N, Konings AWT, El-Feraly FS, Galal AM, Wikstrom HV: Artemisinin-derived sesquiterpene lactones as potential antitumour compounds: cytotoxic action against bone marrow and tumour cells. Planta Med 64:615-619, 1998. *Beekman AC, Woerdenbag HJ, Van Uden W, Pras N, Konings AWT, Wikstrom HV: Stability of artemisinin in aqueous environments: impact on its cytotoxic action to Ehrlich ascites tumour cells. J Pharm Pharmacol 49:1254-1258, 1997. Begum K, Kim HS, Kumar V, Stojilnkovic I, Wataya Y: In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum. Parasitol Res 90(3):221-224, 2003. Benakis A, Paris M, Loutan L, Plessas CT, Plessas ST: Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers. Am J Trop Med Hyg 56:17-23, 1997. Benoit-Vical F, Robert A, Meunier B: In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins. Antimicrob Agents Chemother 44:2836-2841, 2000. Berman PA, Adams PA: Artemisinin enhances heme-catalysed oxidation of lipid membranes. Free Rad Biol Med 22:1283-1288, 1997. Bhattacharjee AK, Karle JM: Stereoelectronic properties of antimalarial artemisinin analogues in relation to neurotoxicity. Chem Res Toxicol 12:422-428, 1999. *Bhisutthibhan J, Philbert MA, Fujioka H, Aikawa M, Meshnick SR: The Plasmodium falciparum translationally controlled tumor protein: subcellular localization and calcium binding. Eur J Cell Biol 78:665-670, 1999. Bhisutthibhan J, Meshnick SR. Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies. Antimicrob Agents Chemother. 45(8):2397-2399, 2001. Bich NN, De Vries PJ, Van Thien H, Phong TH, Hung LN, Eggelte TA, Anh TK, Kager PA: Efficacy and tolerance of artemisinin in short combination regimens for the treatment of uncomplicated falciparum malaria. Am J Trop Med Hyg. 55(4):438-443, 1996. Birku Y, Makonnen E, Bjorkman A: Comparison of rectal artemisinin with intravenous quinine in the treatment of severe malaria in Ethiopia. East Afr Med J 76:154-159, 1999. Bishop LPD, Maggs JL, O'Neill PM, Park BK: Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation. J Pharmacol Exp Ther 289:511-520, 1999. Bodley AL, Cumming JN, Shapiro TA: Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum. Biochem Pharmacol 55:709-711, 1998. Bouwmeester HJ, Wallaart TE, Janssen MHA, van Loo B, Jansen BJ, Posthumus MA, Schmidt CO, De Kraker JW, Konig WA, Franssen MCR: Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis. Phytochemistry 52(5):843-854, 1999. Brewer TG, Peggins JO, Grate SJ, et al: Neurotoxicity in animals due to arteether and artemether. Trans R Soc Trop Med Hyg 88 (supp 1):S1/33-S1/36, 1994. Brewer TG, Grate SJ, Peggins JO, Weina PJ, Petras JM, Levine BS, Heiffer MH, Schuster BG: Fatal neurotoxicity of arteether and artemether. Am J Trop Med Hyg 51:251-259, 1994. Brockman A, Price RN, van Vugt M, Heppner DG, Walsh D, Sookto P, Wimonwattrawatee T, Looareesuwan S, White NJ, Nosten F: Plasmodium falciparum antimalarial drug susceptibility on the northwestern border of Thailand during five years of extensive use of artesunate-mefloquine. Trans R Soc Trop Med Hyg 94:537-544, 2000. Cazelles J, Robert A, Meunier B: Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model. J Org Chem 67:609-619, 2002. Chan KL, Yuen KH, Jinadasa S, Peh KK, Toh WT: A high-performance liquid chromatography analysis of plasma artemisinin using a glassy carbon electrode for reductive electrochemical detection. Planta Med 63:66-69, 1997. Chawira AN, Warhurst DC, Peters W: Qinghaosu resistance in rodent malaria. Trans R Soc Trop Med Hyg 80:477-480, 1986. *Chen HH, Zhou HJ, Fang X: Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Pharmacol Res 48: 231-236, 2003. *Chen HH, Zhou HJ, Wu GD, Lou XE. Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1. Pharmacology. 71(1):1-9, 2004. *Chen H-H, Li-Li Y, Shang-Bin L. Artesunate reduces chicken chorioallantoic membrane neovascularisation and exhibits antiangiogenic and apoptotic activity on human microvascular dermal endothelial cell. Cancer Lett. 211(2):163-173, 2004. *Chen HH, Zhou HJ, Wang WQ, Wu GD. Antimalarial dihydroartemisinin also inhibits angiogenesis. Cancer Chemother Pharmacol. 53(5):423-432, 2004. Chippaux JP, Le Hesran JY, Garcia A, Brasseur P: Recent studies have reported significant toxicity of artemisinin and its derivatives for schistosomula in various Schistosoma species. Am J Trop Med Hyg 69(1):1;author reply 1-2. Clark RL, White TE, A Clode S, Gaunt I, Winstanley P, Ward SA. Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit. Birth Defects Res B Dev Reprod Toxicol. 71(6):380-394, 2004. Classen W, Altmann B, Gretener P, Souppart C, Skelton-Stroud P, Krinke G: Differential effects of orally versus parenterally administered qinghaosu derivative artemether in dogs. Exp Toxic Pathol 51:507-516, 1999. Cumming JN, Ploypradith P, Posner GH: Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action. Adv Pharmacol 37:253-297, 1997. Cumming JN, Wang D, Park SB, Shapiro TA, Posner GH: Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin. J Med Chem 41:952-964, 1998. Davidson DE Jr: Role of arteether in the treatment of malaria and plans for further development. Trans R Soc Trop Med Hyg 88 (supp 1):S1/51-S1/52, 1994. Davis TME, Phuong HL, Ilett KF, Hung NC, Batty KT, Phuong VDB, Powell SM, Thien HV, Binh TQ: Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria. Antimicrob Agent Chemother 45:181-186, 2001. Davis TM, Binh TQ, Ilett KF, Batty KT, Phuong HL, Chiswell GM, Phuong VD, Agus C. Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate in severe falciparum malaria. Antimicrob Agents Chemother 47(1):368-370, 2003. Dayan AD: Neurotoxicity and artemisinin compounds: do the observations in animals justify limitation of clinical use? Med Trop (Mars) 58:32-37, 1998. De Jesus-Gonzalez L, Weathers PJ: Tetraploid Artemisia annua hairy roots produce more artemisinin than diploids. Plant Cell Rep 21(8):809-813, 2003. *Dell'Eva R, Pfeffer U, Vene R, Anfosso L, Forlani A, Albini A, Efferth T. Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti- malarial artesunate. Biochem Pharmacol. 68(12):2359-2366, 2004. de Vries PJ, Dien TK: Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs 52:818-836, 1996. de Vries PJ, Khanh NX, Dien TK, Binh LN, Yen NT, Duc DD, van Boxtel CJ, Kager PA: The pharmacokinetics of a single dose of artemisinin in subjects with liver cirrhosis. Bach Mai-Amsterdam Research Group on Artemisinin. Trop Med Int Health 2:957-962, 1997. de Vries PJ, Dien TK, Khanh NX, Binh LN, Yen NT, Duc DD, van Boxtel CJ, Kager PA: The pharmacokinetics of a single dose of artemisinin in patients with uncomplicated falciparum malaria. Am J Trop Med Hyg 56:503-507, 1997. de Vries PJ, Bich NN, Thien HV, Hung LN, Anh TK, Kager PA, Heisterkamp SH: Combinations of artemisinin and quinine for uncomplicated falciparum malaria: efficacy and pharmacodynamics. Antimicrob Agent Chemother 44:1302-1308, 2000. Delhaes L, Blot C, Berry L, Maciejewski LA, Camus D, Brocard JS, Dive D. Novel ferrocenic artemisinin derivatives: synthesis, in vitro antimalarial activity and affinity of binding with ferroprotoporphyrin IX. Bioorg Med Chem. 8(12):2739-2745, 2000. *Deng DA etal: Derivatives of artemisinin B with antileukemia creativity. ACTA Pharm Sin 27:317-320, 1992. Dhingra V, Rao KV, Narasu ML: Current status of artemisinin and its derivatives as antimalarial drugs. Life Sci 66:279-300, 2000. Dien TK, de Vries PJ, Khanh NX, Koopmans R, Binh LN, Duc DD, Kager PA, van Boxtel CJ: Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects. Antimicrob Agents Chemother 41:1069-1072, 1997. Dong Y, Vennerstrom JL. Mechanisms of in situ activation for peroxidic antimalarials. Redox Rep. 8(5):284-288, 2003. Dost K, Davidson G: Analysis of artemisinin by a packed-column supercritical fluid chromatography-atmospheric pressure chemical ionisation mass spectrometry technique. Analyst 128(8):1037-1042, 2003. Drobitch RK, Svensson CK: Therapeutic drug monitoring in saliva: an update. Clin Pharmacokinet 23:365-379, 1992. Duarte EC, Fontes CJF, Gyorkos TW, Abrahamowicz M: Randomized controlled trial of artesunate plus tetracycline versus standard treatment (quinine plus tetracycline) for uncomplicated Pasmdium falciparum malaria in Brazil. Am J Trop Med Hyg 54:197-202, 1996. Duc DD, de Vries PJ, Nguyen XK, Le Nguyen B, Kager PA, van Boxtel CJ: The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. Am J Trop Med Hyg. 51(6):785-790, 1994. Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S: Artemisinins target the SERCA of Plasmodium falciparum. Nature 424(6951):957-961, 2003. Edwards G, Ward S, Breckenridge A: Interaction of arteether with the red blood cell in-vitro and its possible importance in the interpretation of plasma concentrations in-vivo. J Pharm Pharmacol 44:280-281, 1992. Edwards G: Measurement of artemisinin and its derivatives in biological fluids. Trans R Soc Trop Med Hyg 88 (supp 1):S1/37-S1/39, 1994. Edwards G: Haem-mediated decomposition of artemisinin and its derivatives: pharmacological and toxicological considerations. J Pharm Pharmacol 49 (suppl 2):49-53, 1997. *Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR: The anti-malarial artesunate is also active against cancer. Int J Oncol 18:767-773, 2001. Efferth T, Marschall M, Wang X, Huong SM, Hauber I, Olbrich A, Kronschnabl M, Stamminger T, Huang ES.: Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses. J Mol Med 80:233-242, 2002. *Efferth T, Davey M, Olbrich A, Rucker G, Gebhart E, Davey R.: Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MDR1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. 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