RISK ALERT! November 14, 2007 Attention: ASCIP Members Subject: Methicillin-Resistant Staphylococcus Aureus (MRSA)
ASCIP has received numerous inquiries in regard to MRSA in schools. In mid-October theJournal of the American Medical Association (JAMA) published findings based on a studyconducted by the Center for Disease Control (CDC) which indicated that Methicillin-ResistantStaphylococcus Aureus (MRSA), commonly referred to as staph, infections had resulted inmore deaths than AIDS in 2005. With the release of these reports, MRSA received a great dealof media attention and many cases were being reported around the United States.
To prevent staph and other skin infections, students and staff should practice good personal-hygiene, which include: avoid sharing personal items such as towels and clothing; avoidtouching other people’s wounds or bandages; cover any wounds, cuts, scrapes, boils or otherskin infections with clean bandages; and wash hands thoroughly and often with soap andwater.
In addition to personal-hygiene, school staff should ensure that areas where staph and otherskin infections are most likely to occur receive regular and thorough cleanings. These areasinclude: weight-lifting rooms; wrestling areas; locker rooms; and other areas where sharedequipment may come in direct contact with a person’s skin. The manufacturer’s cleaninginstructions should be consulted when cleaning equipment such as wrestling mats to ensurethat the cleaners will not damage the equipment and/or void any warranties.
In the event that an MRSA infection is reported by staff or students at district or school sites,the district should contact the local public health department per California Code ofRegulations Title 17, Section 2508 - “It shall be the duty of anyone in charge of a public orprivate school, kindergarten, boarding school, or day nursery to report at once to the localhealth officer the presence or suspected presence of any of the communicable diseases.” Thelocal health officer may request the district to isolate affected individuals, isolate rooms, notifyaffected parties and/or take other necessary actions to control the communicable disease. ASCIP staff verified with the California Department of Public Health that MRSA is areportable communicable disease and is required to be reported to the local health department.
Schools may elect to ensure that parents are aware of the concerns related to MRSA and wheresuspect exposures are observed, develop a mechanism by which those parents might be alertedto such exposures.
Please review the attached bulletin from the California Department of Public Healthhttp://www.cdph.ca.gov/healthinfo/discond/Documents/07MRSAschool.pdf ASCIP staff isavailable to assist in addressing potential MRSA exposure concerns as they may arise.
State of California—Health and Human Services Agency
MARK B HORTON, MD, MSPH ARNOLD SCHWARZENEGGER Skin Infections and MRSA Information for California Schools
Students, faculty and staff at schools should be sensitive to the possibility of disease transmission; including respiratory diseases (influenza, colds, tuberculosis) and diseases that are spread primarily through direct contact or contact with contaminated objects (such as lice and scabies). The media has recently focused on the spread of skin infections caused by methicillin-resistant Staphylococcus aureus (MRSA), especially among school children. Most skin infections, regardless of cause, can be easily treated if identified in a timely manner. This document is written to address the concerns of the educational community in California about MRSA but the prevention principles outlined are applicable to most skin infections. What is Staphylococcus aureus? Staphylococcus aureus, often referred to simply as "staph," are bacteria that are most commonly carried in the noses of healthy people. Approximately 25-30% of the population are colonized (when bacteria are present, but not causing an infection) in the nose with staph bacteria. Staph can also be carried in the armpit, groin, rectum, or genital area. Staph bacteria are one of the most common causes of skin infections in humans. Most of these skin infections are minor (such as boils and abscesses) and smaller infections can be often be treated with incision and drainage without antibiotics. However, staph also can cause serious infections such as pneumonia, bloodstream infections, and joint infections. In the past, these staph infections typically have been easy to treat with inexpensive antibiotics. Now in most communities in the U.S., over half of the staph causing skin infections are resistant to commonly used antibiotics. What is methicillin-resistant Staphylococcus aureus (MRSA)? Methicillin-resistant Staphylococcus aureus (MRSA) is Staphylococcus aureus that is resistant to all penicillins (including dicloxacillin and other methicillin-related antibiotics) and cephalosporins, such as Keflex®. Until recently, most MRSA infections occurred among hospitalized patients. However, recently newer, more virulent strains of MRSA have emerged in the community, causing community-associated MRSA infections. The reasons for the emergence of these new strains are not entirely clear. What is clear is that community-associated MRSA strains did not originate from the strains of MRSA that have caused infections in hospitals and other healthcare facilities for decades.
Division of Communicable Disease Control/Infectious Diseases Branch
850 Marina Bay Parkway, Building P 2nd Floor, Richmond, CA 94804
What increases the risk for MRSA skin infections? The following factors increase the risk of MRSA skin infections:
• Compromised skin (such as cuts or abrasions)
• Contact (frequent skin-to-skin)
with contaminated items and surfaces
• Crowding, and
• Difficulty keeping skin clean or not cleaning skin after a cut or abrasion
The occurrence of an MRSA skin infection does not mean that the person is not clean or has been in an unhygienic environment. Some persons with no apparent risk factors for MRSA infection may come into contact with the bacteria at the same time that they have a small break in the skin and this can result in an infection in what had appeared to be normal skin. How is MRSA spread? MRSA spreads easily through direct contact with people or contact with MRSA contaminated surfaces or items. MRSA is spread more frequently in crowded areas such as locker rooms, dormitory rooms, or other crowded living conditions, particularly when skin-to-skin contact is likely. In school settings, there are many opportunities for skin-to-skin contact among students, especially those on athletic teams or in residential facilities. Most infections occur when staph that is already on the skin enters through a break in the skin (cut or scrape), or when broken skin is in contact with MRSA contaminated objects (such as shared athletic equipment, clothing, towels, or razors). Contaminated hands can also transfer MRSA to cuts or scrapes on the skin. Staph is not usually passed through the air. Why should school health professionals be concerned about MRSA? School health professionals (i.e., school nurses and school physicians) can play an important role in disseminating information about MRSA to staff, students, and parents and may also provide care for infected students and refer infected students to healthcare providers. School health professionals should ensure that they have the most accurate and up-to- date information on MRSA. One student with a severe MRSA infection or an outbreak of skin infections can cause much anxiety for parents, students and staff. Although concern about MRSA is greatest following the occurrence of a severe infection, the risk to other students does not depend upon the severity of an infection but rather the number of students infected with MRSA and the circumstances under which infections are occurring. An outbreak among an athletic team may not pose a significant risk to other students, as long as the infected athletes are receiving appropriate treatment and follow recommended prevention measures. Students with skin infections may need to be referred to a healthcare provider for diagnosis and treatment. School health professionals should notify parents/guardians of the affected students when possible skin infections are detected. Identifying an MRSA
infection can be difficult because the symptoms of MRSA infection are the same as those of other skin infections. MRSA can only be diagnosed by culture and antibiotic susceptibility testing. Unfortunately, misdiagnosis (e.g., many MRSA infections are misdiagnosed as spider bites) or delayed diagnosis of MRSA infection can result in delayed treatment and more serious complications. School health professionals may provide care to students with skin infections. When such care is provided, standard precautions should be used (e.g., hand hygiene before and after contact, wearing gloves) when caring for nonintact skin or potential infections. Should students with MRSA skin infections be excluded from school? Unless directed by a physician, students with MRSA infections should not be excluded from attending school. Students who have draining infections that cannot be covered and contained should be excluded from school until the infection is healed or can be covered and contained. If the student is involved in a physical activity or sport that involves skin-to-skin contact with other students, they should be excluded from those activities until the lesions are healed or can be covered and contained adequately; return to those activities should be approved by a school official or doctor. Do schools need to be closed and disinfected if a student is diagnosed with MRSA? No, it is not necessary to close the school if a student is suspected of or diagnosed with an MRSA infection. MRSA skin infections are transmitted primarily by skin-to-skin contact and contact with surfaces or items that have come into contact with MRSA wound drainage. Ensuring that skin infections are covered will greatly reduce the risk of contaminating surfaces or items with MRSA or other bacteria. When MRSA skin infections occur, cleaning and disinfection should be performed on surfaces or items that are likely to have had contact with uncovered or poorly covered infections. Cleaning surfaces with routinely used detergent-based cleaners or Environmental Protection Agency (EPA)-registered disinfectants is effective at removing MRSA. It is important to read the instruction labels on all products to make sure they are used safely and appropriately. For example, many disinfectants require at least 30 seconds of contact time on a surface to ensure killing of bacteria. Environmental cleaners and disinfectants should not be used to treat infections. The EPA provides a list of EPA-registered products effective against MRSA: . It is important to note that since MRSA infections are now common in the community; the location of acquisition/transmission may not be in the schools. Should the entire school community be notified of every MRSA infection? No, it is usually not necessary to inform the entire school community about a single MRSA infection. When an MRSA infection occurs within the school population, the school nurse and school officials should determine which students, parents, and staff should be notified based on the athletic activities and close contacts of the infected
student. Consultation with local public health authorities should be used to guide this decision. Remember that staph bacteria have been and remain a common cause of skin infections and that most infections are not associated with severe disease. Consideration may be given to notifying the school community of an outbreak of staph or other infections when additional measures are being taken to control the outbreak. What should teachers know about MRSA? Teachers can recognize children with open draining wounds or other infections and refer them to the school nurse. In addition, teachers can help prevent the spread of MRSA and other infections by enforcing student hand hygiene with soap and water or alcohol-based hand sanitizers before eating and after using the restroom and can help protect themselves from becoming infected with MRSA and other infections by also using good hand hygiene. What do schools need to do to reduce the spread of skin infections? Hand hygiene by washing hands with soap and water or using an alcohol-based hand sanitizer is the single most important measure that can be taken to prevent the spread of skin infections and should be emphasized to students and staff. Hands should be clean before they touch the eyes, mouth, nose, or any cuts or scrapes on the skin. School staff serve as role models and should wash hands or use an alcohol-based hand sanitizer frequently. If hands are visibly soiled, they should be washed with soap and water. Hand washing procedure:
1. Use warm water and wet hands and wrists; 2. Use a bar or liquid soap (antimicrobial soap is not necessary to remove MRSA); 3. Work soap into a lather and wash palms, back of hands up to wrists, between
fingers, around thumbs, and under fingernails for at least 15 seconds (about the time it takes to sing “Happy Birthday” or “Row, Row, Row Your Boat”);
4. Rinse well under warm, running water, and 5. Dry hands, using a disposable paper towel or hand-dryer.
Hand sanitizer procedure: Apply a dime sized amount of hand sanitizer to the palm of one hand; rub hands together covering all surfaces of hands and fingers until all hand sanitizer is absorbed. To be effective, hand sanitizers must be at least 60% alcohol (check label) and used on hands that are clear of visible dirt. If there is any visible dirt, hand sanitizers are not fully effective and hands should be washed with soap and water. When should hands be cleaned?
• Whenever there is bare skin contact with others or with shared surfaces or
• After sneezing, coughing, blowing or touching nose,
• Before and after touching wounds, the mucous membranes of your eyes, nose,
or mouth, or non-intact skin like acne, boils and skin rashes,
• After using the toilet or urinal, and,
• Before preparing food, eating, or drinking.
How can infected students minimize spreading it to others? Those infected with MRSA should following these steps to minimize spreading the infection to others:
• Cover the wound. Keep wounds that are draining or have pus covered with
clean, dry bandages. Follow the healthcare provider’s instructions on proper care of the wound. Drainage and pus from infected wounds can contain large amounts of bacteria, so keeping the infection covered will help prevent the spread of infections to others. Bandages or tape can be discarded with the regular trash.
• Clean hands. The student, their family, and others in close contact with the
infected student should clean their hands frequently with soap and warm water or an alcohol-based hand sanitizer, especially after changing bandages or touching an infected wound.
• Do not share personal items. Avoid sharing personal items such as towels,
washcloths, razors, clothing, or sports uniforms/equipment that may have had contact with the infected wound or bandage. Wash sheets, towels, and clothes, including sports uniforms that become soiled, with water and laundry detergent. Drying clothes in a hot dryer also helps kill bacteria.
• Inform healthcare providers who treat them that they are or have been infected
Is MRSA a reportable disease in California? MRSA is not a reportable disease in California. However, it is reportable in a few counties including Santa Clara and San Mateo. Contact your local health department if there is an outbreak of skin infections occurring at your school. Are there any educational materials available on MRSA? Yes, educational materials can be found at the following websites: CDPH: including
CDC: AWARE: Washington State Department of Health:
”Hepatitis event” i Dansk Virologisk Selskab In vitro and in vivo studies of the molecular Dept. of Infectious Diseases and Clinical Hospital, Hvidovre and Faculty of Health Program organized by Dr. Allan Randrup Thomsen ”Hepatitis event”, Dansk Virologisk Selskab Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, IN VITRO AND IN VIVO STUDIES OF THE MOLECULAR VIROLOGY
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