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JACK D. SOBEL, M.D.

ACADEMIC OFFICE:
HOME ADDRESS:
E-mail jsobel@med.wayne.edu
PATIENT OFFICE:
3730 Woodward – Ste 200
Detroit, MI 48201
313-966-7601 – office
PERSONAL DATA:
EDUCATION:
1965
MBBCh Degree, University of the Witwatersrand, Johannesburg, South Africa
POSTGRADUATE TRAINING:
01/66 - 06/66
Intern in Internal Medicine, Johannesburg General Hospital, Johannesburg, South Africa Intern in Surgery, Johannesburg General Hospital, Johannesburg, South Africa Medical Officer, South African Defense Force Resident in Pediatrics, Johannesburg Children's Hospital, Johannesburg, South Africa Resident in Internal Medicine, Baragwanath Hospital, Johannesburg, South Africa Resident in Cardiology, Rambam University Hospital, Haifa, Israel Resident in Internal Medicine, Rambam University Hospital, Haifa, Israel Research Fellow in Infectious Diseases, Laboratory of Clinical Investigation, National Institute of Allergic and Infectious Diseases, NIH, Bethesda, MD Fellow in Infectious Diseases, The Medical College of Pennsylvania, Philadelphia, PA
FACULTY APPOINTMENTS:

Jack D. Sobel, M.D.
Curriculum Vitae
Page 2

Assistant Professor of Medicine, Full-Time Lecturer, Department of Internal Medicine, Technion School of Medicine, Haifa, Israel Assistant Professor of Medicine, The Medical College of Pennsylvania, Philadelphia, PA Associate Professor of Medicine, Division of Infectious Diseases, The Medical College of Pennsylvania, Philadelphia, PA 1985 - Present
Professor of Medicine, Department of Internal Medicine, Wayne State
University School of Medicine, Detroit, MI

1987 - Present
Professor, Department of Immunology and Microbiology, Wayne State
University School of Medicine, Detroit, MI

1989 - Present
Professor, Department of Obstetrics and Gynecology, Wayne State
University School of Medicine, Detroit, MI

2008 – Present
Distinguished Professor of Medicine, Department of Internal Medicine,
Wayne State University School of Medicine, Detroit, MI

2009 – Present
Associate Chairman for Research, Department of Internal Medicine

HOSPITAL OR OTHER PROFESSIONAL APPOINTMENTS:
1978 - 1979
Section Chief, Infectious Diseases, VA Hospital, Philadelphia, PA Chief, Infectious Diseases, Rambam Medical Center, Technion Medical School, Haifa, Israel 1985 - Present
Chief, Infectious Diseases, Hutzel Hospital, Detroit, MI
1985 - Present
Chief, Division of Infectious Diseases, Wayne State University School of
Medicine, Detroit, MI

1987 - Present
Chief, Infectious Diseases, Harper Hospital, Detroit, MI

MAJOR PROFESSIONAL SOCIETIES:
Fellow, American College of Physicians, 1983
Fellow, American Society of Infectious Diseases, 1987
Member, American Society of Microbiology, 1976
Member, American Federation of Clinical Research, 1986
Member, Wayne County Medical Society & Michigan State Medical Society, 1986
Member, American Medical Association, 1986
Member, Michigan Infectious Diseases Society, 1985
Member, National Institutes of Health Alumni Association, 1988
Member, Mycosis Study Group (MSG), NIAD, National Institutes of Health, 1991
Member, International Society for Human and Animal Mycology (ISHAM), 1991
President, Michigan Infectious Diseases Society, 1997 - 1999
Member, Infectious Diseases Society of America, National State President’s Committee, 1998-
present
Member, Infectious Diseases Society of America, Practice guidelines Committee, 1999-

Jack D. Sobel, M.D.
Curriculum Vitae
Page 3

Present
Member, International Society for the Study of Vulvovaginal Disease (ISSUD), 2007-
present
MEDICAL LICENSURE:

Licensure - States of Maryland, Pennsylvania and Michigan
BOARD CERTIFICATION:
Fellow, College of Physicians South Africa, 1970
Member, Royal College of Physicians of the United Kingdom, 1970
Diplomate, American Board of Internal Medicine, 1978
Diplomate, Infectious Diseases, 1982
HONORS/AWARDS:
Graduated from Medical School, University of Witwatersrand with honors.
Suzman Gold Medal (1970) awarded to the most outstanding medical resident
performance in the Fellow of the College of Physicians (South Africa)
examination (Boards to Internal Medicine).
Golden Apple Award from third year class. Award for best clinical teacher
in Medical School Clinical Faculty for third year, The Medical College of
Pennsylvania (1979).
Medical House Staff Annual Award for Excellence in Clinical Teaching
(1984/1985). The Medical College of Pennsylvania
Distinguished Faculty Award, Department of Internal Medicine (1986/1987),
Wayne State University
2004 School of Medicine Teaching Award
Nomination to the Provost's Office WSU Distinguished Faculty Fellowship, 2004
Best Doctors in America Award, 1992, 1996, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005,
2006, 2007, 2008
Gershenson Distinguished Faculty Award, WSU, 2008

SERVICE:
Wayne State University/DMC:

1985-1988
V.A. Research and Development Committee (Deans representative) Chairman, Pharmacy and Therapeutic Committee, Hutzel Hospital 1985-present Affiliated Internists Board of Directors (formally University Internists) 1985-1988 1986-present Michigan Infectious Diseases Society 1986 Chairman, WSU Search Committee for New Chairman of Jack D. Sobel, M.D.
Curriculum Vitae
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Executive Committee DMC Joint Venture Laboratory 1989-present Promotion and Tenure Committee, Dept. of Medicine, WSU 1989-1990 Search Committee for Chairman Department of Obstet. Gynecol. Sabbatical Leave Committee, Wayne State University Chairman of Promotion and Tenure Committee, Department of Medicine, WSU Chairman of the LCME, Department of Surgery Review Committee, WSU School of Medicine Executive Committee of Faculty Senate, WSU School of Medicine Executive Subcommittee on Faculty Tenure, WSU School of Medicine Chairman, Executive Subcommittee on Year III & IV Curriculum Chairman, Ad Hoc TB Committee for the Detroit Medical Center Chairman, Search Committee for Pulmonary Division Chief, Department of Internal Medicine Chairman, Educational Task Force on Year III & IV Curriculum Search Committee for Chairman, Department of Dermatology Department of Surgery, Wayne State University, 5 Year Internal Review Wayne State University Task Force for Conflict of Interest in Research 2001-present Chair, Committee for Department of Internal Medicine Medical Records 2002-2003 Member, HIPAA Committee (WSU School of Medicine) Committee for Chief, Division of Hematology/Oncology Member, Immunology/Microbiology Departmental Review Committee Member, Wayne State University School of Medicine Dean Search 2006-2007
Member of the Wayne State University Clinical Trial Office (CTO)
Committee (Chaired by N. Rossi)
2006-2007
Member of the Department of Medicine – Medical Education Committee
(Chaired
2006-2008
Member of ad hoc Committee WSU Task Force on Clinical Research
(Chaired by J. Oliver)
2006-2008
Member, Karmanos Cancer Institute Clinical Leadership Council
2006-present Member, Research Committee, Department of Internal Medicine.
2006-present Member, Detroit Medical Center Research Grant Committee
2006-present Member, Clinical and Translational Science Award (CTSA) Planning and

Strategic Committee (Chaired by M Diamond)
2008-present Member, WSU Advisory Working Committee for CTSA

Jack D. Sobel, M.D.
Curriculum Vitae
Page 5

SCHOLARLY SERVICE:
EDITORIAL BOARDS

1985-1989
1994-Present Newsletter of Columbia University School of Public Health, Scientific studies of 1995-Present Associate Editor: Infectious Diseases in Obstetrics and Gynecology 2001-Present Editorial Board: Sexually Transmitted Infections 2001-Present Editorial Board: BioMed Central
CONSULTANT:
Centers for Disease Control and Prevention, Special Committee for recommending Guidelines for
treatment of Sexually Transmitted Diseases, 1993 and 1997, 2000, 2009
JOURNAL REVIEWER (Ad Hoc)
American Journal of Medicine
American Journal of Obstetrics and Gynecology
Annals of Internal Medicine
Antimicrobial Agents and Chemotherapy
Infection and Immunity
Journal of Infectious Diseases
Medical Mycology
New England Journal of Medicine
Obstetrics and Gynecology
Reviews of Infectious Disease

TEACHING:
Mentoring (2008):
1.
Dr Orna Reichman, I.D./Gyn Fellow (2007-09) Sarah Kabbani, M.D., Resident, (2008-09)
2008 Lectures
1.
I.D. Grand Rounds, Harper University Hosp, Detroit, MI, (Students, residents, fellows, Infectious Diseases Clinical Consult Rounds, (Students, residents, fellows) Infectious Disease Tutorial Lectures, (Residents and students) Infectious Disease Research Conference, (Students, residents, fellows, attendings) Jack D. Sobel, M.D.
Curriculum Vitae
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Grand Rounds, William Beaumont Hospital 1/31, (Students, residents, fellows, Astellas Meeting, “Antifungals”, Deerfield, IL (Astellas) 2/14, (ID attendings) Hospitalist Lecture, “STDs”, Detroit Receiving, 3/13, (Hospitalists) 5th World Vaginitis Conference, “Research Advances in VVC”, Turkey, 5/1 Ob/Gyn Society of Colombia “VVC and BV”, Colombia 5/29 MSMS Lecture, “STD’s”, CME Symposium, Annual Update, 10/22, (Primary Care ICAAC/IDSA Meeting, Plenary Session, “Echinocandins”, 10/25, (I.D. Specialists) Lecture at Henry Ford Hospital, “Sexually Transmitted Diseases”, Detroit, 11/6, (I.D. Lecture at the University of Mississippi, “Infectious Vaginitis”, 11/7, (I.D. Physicians) WSU New faculty orientation lecture, “Research Environment” 11/13, (General Junior NIH, Opening Plenary Session, “BV”, 11/20, (Research specialists, Epidemiologists) Didactic Lecture, “UTI”, 11/24, Residents and interns
GRANTS, CONTRACTS AND OTHER FUNDING:
1982 - 1983
Ketoconazole cyclical prophylaxis in prevention of Recurrent vulvovaginal candidiasis. Janssen Pharmaceutica - $25,000. Bacterial adherence in pathogenesis of urinary tract infections in elderly. National Institute of Aging - Program Project Grant, Philadelphia Geriatric Center, Medical College of Pennsylvania. P.I. Donald Kaye. - $25,000/year x 3 years. Maintenance prophylaxis in recurrent vulvovaginal candidiasis. Janssen Pharmaceutica - $30,000. Double Blind Safety and Efficacy Evaluation of 0.8% and 1.6% Terconazole Cream vs. Placebo Cream for 3 days in patients with Vulvovaginal Candidiasis. Ortho Pharmaceuticals, Inc. - $21,960. Comparison of Oral Ketoconazole Tablets to Vaginal Clotrimazole Tablets in Chronic or Recurrent Vulvovaginal Candidiasis. Janssen Pharmaceuticals - $40,000. Itraconazole Capsules in the Treatment of Acute Vulvovaginal Candidiasis. Janssen Pharmaceuticals - $21,735. Jack D. Sobel, M.D.
Curriculum Vitae
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Double-blind study to compare the in vivo effects of monistat 7 vaginal cream and terazol 0.4% vaginal cream and placebo cream on vaginal flora in patients with vulvovaginal candidiasis. Ortho Pharmaceutical Corp. -$65,595. Clindamycin Vaginal Cream vs. Placebo Vaginal Cream in the Treatment of Bacterial Vagnosis. UpJohn Company - $35,000. Sch. 39,304 versus placebo, oral therapy of acute candida vaginitis. Schering Pharmaceuticals - $60,000. Evaluation of Intravaginal Metronidazole Gel vs. Intravaginal Sultrin Cream for the Treatment of Bacterial Vaginosis. Curatek Pharmaceuticals - $22,500. Double Blind Evaluation of Replens & Placebo in the Prevention of Recurrence of Bacterial Vaginosis. Columbia Research Laboratories - $57,800. Safety and Efficacy Comparison Study of a Saperconazole 60 mg Ovule or 120 Ovule vs Clotrimazole 500 mg Tablet. R.W. Johnson Pharmaceutical Research Institute - $31,959.78. Evaluation of Safety and Efficacy of Vagisil Cream in Women Having an Acute Yeast Infection. Combe Incorporated - $15,000. Open, Comparative Multi-centered study of Fluconazole versus Amphotericin B in the Treatment of Candidemia in Non-neutropenic Patients. Pfizer Pharmaceuticals - $90,588.60. A Randomized Double Blind Protocol comparing Amphotericin B with Flucytosine to Amphotericin B alone followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal meningitis. A Multicenter Trial of the AIDS Clinical Trials Group and the Mycoses Study Group. Janssen Research Foundation and The National Institute of Allergy and Infectious Diseases - $106,932.00. A Prospective Multicenter Randomized Comparison of Fluconazole and Placebo in the Treatment of Funguria. Pfizer Pharmaceuticals and Barton/Polansky Associates Inc. - $51,662.00. Jack D. Sobel, M.D.
Curriculum Vitae
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Fluconazole versus Clotrimazole in the treatment of candidal vaginitis. Pfizer Pharmaceuticals - $40,000. HER Study, "HIV Epidemiological Cohort", Principal Investigators-P. Schuman, and JD Sobel, Centers for Disease Control, - $1,100,000 annual budget. Safety and Efficacy of 0.75% Metronidazole Vaginal Gel for the Treatment and Prevention of Recurrent Bacterial Vaginosis. Curatek Pharmaceuticals - $24,503. Double-Blind, Randomized, Comparative Study of Itraconazole and Fluconazole as Maintenance Therapy for Preventing Relapse of AIDS-Related Cryptococcal meningitis. Janssen Research Foundation - $32,096. Efficacy of Clindamycin vaginal cream prophylactic treatment regimen to prevent recurrent Bacterial Vaginosis - A Randomized, placebo-controlled trial. Upjohn Company - $80,720. Funguria Surveillance Project. Duke University Medical Center - $12,500. A Multi-Center prospective, randomized, double-blind parallel group comparison of the Clotrimazole 3-day treatment regimen (5 grams of Clotrimazole 2% cream daily for 3 days). Miles Inc. - $19,540. Candidiasis in HIV positive and matched HIV-negative women. HER Study Subcontract. Centers for Disease Control. P.I. J.D. Sobel, $75,000/annum. A Multicenter Study to evaluate the safety and efficacy of various doses of AR-121 in non-neutropenic patients with Candidemia. Argus Pharmaceuticals, Inc. P.I. J.D. Sobel - $120,000. An open, comparative multicenter study of Fluconazole vs. Fluconazole plus Amphotericin B in the treatment of Candidemia and its consequences in non-neutropenic patients. Pfizer Research Laboratories, P.I. J.D. Sobel - $39,237. A randomized double blind Multicenter study comparing two dosing regimens of Fluconazole for the treatment of acute vaginal candidiasis in women with severe and/or recurrent infections. Pfizer Research Jack D. Sobel, M.D.
Curriculum Vitae
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Laboratories, P.I. J.D. Sobel - $17,417. Efficacy of Clindamycin Vaginal Ovule (3 day treatment) versus Clindamycin vaginal cream (7 day treatment) in Bacterial Vaginosis. The UpJohn Company, P.I. J.D. Sobel - $30,090. A randomized, double blinded, placebo-controlled trial of the presumptive use of fluconazole in febrile intensive-care unit patients at risk for fungal infections. Pfizer, Inc., P.I. J.D. Sobel - $65,062.50. An open-label, two center study of the efficacy and safety of four dosing regimens of 5% boric acid vaginal gel for the treatment of symptomatic yeast vulvovaginitis. Curatek Pharmaceuticals, P.I. J.D. Sobel - $14,712. A randomized, double-blind, comparative trial of two doses of ambisome versus Amphotericin B followed by fluconazole in the treatment of acute cryptococcal meningitis in AIDS patients. Fujisawa U.S.A., Inc., P.I. J.D. Sobel - $220,000. A Phase IV Randomized Study of the use of fluconazole as chronic suppressive therapy versus episodic therapy in HIV-positive subjects with recurrent oropharyngeal candidiasis. Pfizer, Inc., P.I. J.D. Sobel - $66,200. An open comparative multicenter study of intravenous itraconazole followed by itraconazole oral solution versus intravenous fluconazole followed by oral fluconazole tablets in the treatment of candidemia in non-neutropenic patients. Janssen Pharmaceutica, Inc. P.I. J.D. Sobel - $50,700. Dose escalating and safety evaluations of topical clonidine in patients with vulvodynia. Curatek Pharmaceuticals, P.I. J.D. Sobel - $16,263.00. CAN-296 Candida Research, IGG International, Inc. P.I. J.D. Sobel - $50,000.00. A randomized, double-blind multicenter study comparing fluconazole vs. placebo for the maintenance/prophylactic therapy of vaginal candidiasis in women with recurrent infections. Pfizer, Inc. P.I. J.D. Sobel - $117,915.00. Cromolyn-sodium 4% therapy of vulvovestibulitis in women Placebo
Controlled. (Unfunded).
Jack D. Sobel, M.D.
Curriculum Vitae
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Cromolyn-sodium 4% as therapy for pruritus vulvae. Persutti Laboratories, P.I. J.D. Sobel - $50,000.00. Metronidazole-gel in treatment of recurrent bacterial vaginosis. 3 M Pharmaceuticals, P.I. J.D. Sobel - $400,000.00. Team leader of NIAID/MSG Study Group for the Treatment of Fungal Infections in Non-Immunocompromised Hosts. Salary Support - $75,000/annum. Johnson & Johnson. Focused giving grant. PCR-based analysis of dynamic changes in vaginal bacteriophage and bacterial species in women with recurrent bacterial vaginosis. ($80,000/yr x 2 yrs) P.I. Pfizer Research Award. An analysis of voriconazole resistance mechanisms using a high copy plasmid transformation system in Candida albicans. ($20,000) P.I. 1/04 – 12/04 Rockeby Biomedical Corp. Ltd. Assessment of clinical performance SysCan3 ELISA and CamDea5 as aids in the diagnosis of VVC. ($15,000) P.I. PPD Development. LP Protocol #BT0300C1-300-USA. A multi-center, randomized, double-blind comparative safety and efficacy study of a single dose of 400 mg itraconazole given as 2 200 mg film-coated tablets vs. a single dose of 150 mg fluconazole. ($11,116) P.I. Pliva. PLD-118. Antifungal activity of PLD-118 against Candida albicans: conditions for susceptibility, synergy, and identification of resistance genes. ($51,000) P.I. Abbott Research Group. Protocol #ARG604. A clinical study of treatment of symptomatic bacterial vaginosis with water works douching device versus non-treatment. ($7,379) P.I. Merck. Protocol #2-01-MK0991. A randomized double blind placebo controlled trial of caspofungin vs. placebo as prophylaxis of invasive candidiasis in high risk adults in the critical care. ($61,258) P.I. Presutti Laboratories. LLC T-500. A phase 3 randomized, multi-center, double- blind, double-dummy, placebo-controlled treatment trial of bacterial vaginosis with tinidazole oral tablets. ($10,070) P.I. Jack D. Sobel, M.D.
Curriculum Vitae
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Michigan Development Corp MTTC. Microfluids PCR Diagnosis of R03, Fujisawa Healthcare Inc, “A Phase 3 Randomized Double Blind “A randomized prospective single –blinded multicenter comparison study of the Water Works Douching Device versus a commercially available over-the-counter douching device for the reduction or abatement of perceived vaginal odor with or without complaints of discharge in “Non-toxic gel to treat vulvovaginal candidiasis”, ($8,515), PI Toltec Pharmaceuticals, “Infectious Diseases in Obstetrics and Merck, “PCR based models to monitor the efficacy of prophylactic use of Caspofungin in high risk intensive care patients”, ($72,800), PI Anacor Pharmaceuticals, “Experimental Candida vaginitis in rats”, Merck, “Caspofungin for experimental vaginal candidiasis in rats”, ($5,000) Common Sense, “VS-Sense swab in diagnosis of vaginitis,” ($10,000) “PCR-Diagnosis of chlamydia infections in women with idiopathic vestibulitis and pseudoinflammatory ectoprion”. Jack D. Sobel, M.D.
Curriculum Vitae
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PUBLICATIONS:
Reports of Original Work

1.
Sobel JD, Fanaroff A: Cytomegalovirus infection and elevated alkaline phosphatase. Lancet, September 1968. Pimstone B, Sobel JD, Meyer E: Diencephalic syndrome of childhood - secretion of growth hormone. J Pediatr 76:886-889, 1970. Sobel JD, Haim S, Shafrir A, Gellei B: Cutaneous hyper-reactivity in Behcet's disease. Dermatologica 146:350-356, 1973. Sobel JD, Tabori S, Tatarski I: Venous thrombosis and fibrinolysis in Behcet's diseases. Dermatologica 148:93-97, 1974. Chosen for review in 22nd Rheumatism Review, 1975, and Dermatology Digest, 1974. Sobel JD, Obedeanu N, Merzbach D: NBT in the diagnosis of febrile patients (study of 300 patients). S African Med J 47:1407-1409, 1973. Haim S, Sobel JD, Friedman R: Thrombophlebitis - a cardinal sign in Behcet's disease. ACTA Dermatovener (Stockholm) 54:299-301, 1974. Sobel JD, Haim S: Fibrinolytic agent in the treatment of Behcet's disease. La Revue de Medicine, 1974. Haim S, Sobel JD, Friedman R, Lichtig C: Histological and direct immunofluorescence study of cutaneous hyper-reactivity in Behcet's disease. Br J Dermatol 95:63l-635, 1976. Sobel JD, Haim S, Obedeanu N, Meshulam T, Merzbach D: Polymorphonuclear leukocyte function in Behcet's disease. J Clin Path 30:35-353, 1976. Haim S, Makori T, Sobel JD, Robinson E: Lymphocyte function in Behcet's disease. Dermatologica 53:34-37, 1976. Sobel JD, Gallin JI: Polymorphonuclear and mononuclear cell chemoattractants elaborated by human skin fibroblasts. J Clin Invest 63:609-618, 1979. Sobel JD, Tchao R, Bazzola J, Levison ME, Kaye D: Human vaginal multilayer tissue cultures - a new method for study. In Vitro 15:993-1000, 1979. Jack D. Sobel, M.D.
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Sobel JD, Levison ME, Kaye D: Role of menstrual cycle in bacterial adherence to vaginal epithelial cells. Infect Immun 32:194-197, 1981. Sobel JD, Myers P, Levison ME, Kaye D: C. albicans adherence to vaginal epithelial cells. J Infect Dis 143:76-82, 1981. Sobel JD, Kaye D, Levison ME: Comparison of bacterial and fungal adherence to exfoliative cells and tissue culture system. Infect Immun 35:697-701, 1982. Sobel JD, Kaye D, Levison ME: BAY K 4999 - in vitro activity against enterobacteriaceae and pseudomonas. Infect 8:121-122, 1980. Sobel JD, Hasman N, Reinarz G, Merzbach D: Pseudomonas cepacia contamination of chlorhexidine antiseptic. Am J Med 73:183-186, 1982. Sobel JD, Vardi Y: Scanning electron microscopy study of pseudomonas adherence to rat bladder. J Urol 128:414-417, 1982. Vardi Y, Sobel JD: In vivo adherence of Pseudomonas aeruginosa to rat bladder epithelium. Proc Soc Exp Biol Med 172:449-456, 1983. Sobel JD, Muller G: Comparison of ketoconazole, BAY N7133, and BAY L9139 in the treatment of experimental vulvovaginitis. Antimicrob Agents Chemother 24:434-436, 1983. Sobel JD, Obedeanu N: The effect of subinhibitory concentrations of ketoconazole on adherence of Candida albicans. Eur J Clin Microbiol 2:445-452, 1983. Raz R, Merzbach D, Sobel JD, Finkelstein R: Absence of S. saprophyticus in urinary tract infections in Israel. Israel J Med Sci 19:566-567, 1983. Sobel JD, Muller G: Ketoconazole prophylaxis in experimental vaginal candidiasis. Antimicrol Agents Chemother 25:281-282, 1984. Sobel JD, Obedeanu N: Hydrophobicity and adherence of gram negative bacteria. Ann Clin Lab Sci 14:216-223, 1984. Sobel JD, Muller G, Buckley H: Critical role of germination in the pathogenesis of experimental candidal vaginitis. Infect Immun 44:576-580, 1984. Meshulam T, Obedeanu N, Merzbach D, Sobel JD: Phagocytosis of mucoid and nonmucoid Jack D. Sobel, M.D.
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pseudomonas. Clin Immunol Immunopath 32:151-165, 1984. Sobel JD, Muller G: Comparison of itraconazole and ketoconazole in experimental vulvovaginal candidiasis. Antimicrol Agents Chemother 26:266-267, 1984. Sobel JD, Muller G: Vaginal cells susceptibility to adherence in pathogenesis of urinary tract infection in the elderly. Gerontol 38:682-685, 1984. Finkelstein R, Sobel JD, Nagler A, Merzbach D: Staphylococcus aureus bacteremia and endocarditis: comparison of nosocomial and community-acquired infection. J Med 193-210, 1984. Sobel JD: Management of recurrent vulvovaginal candidiasis with intermittent ketoconazole prophylaxis. Obstet Gynecol 65:435-440, 1985. Sobel JD, Muller G, McCormick JF: Experimental vaginal candidosis in rats. Sabouraudia 23:199-206, 1985. Sobel JD, Kaye D: Reduced uromucoid excretion in the elderly. J Infect Dis 152:653, 1985. Reinhart H, Muller G, Sobel JD: Specificity and mechanism of in vitro adherence of Candida albicans. Ann Am Lab Sci 15:406-413, 1985. Trumbore DJ, Sobel JD: Recurrent vulvovaginal candidiasis: Vaginal epithelial cell susceptibility to Candida albicans adherence. Obstet Gynecol 67:810-812, 1986. Sobel JD, Kaye D: Enhancement of Escherichia coli adherence to epithelial cells derived from estrogen stimulated rats. Infect Immun 53:53-56, 1986. Buckley HR, Daneo-Moore L, Ahrens JC, Sobel JD: Isolation of a germ-tube-forming revertant from Candida albicans B3111V6. Infect Immun 53:13-15, 1986. O'Conner MI, Sobel JD: Epidemiology of recurrent vulvovaginal candidiasis: identification and strain differentiation of Candida albicans. J Infect Dis 154:358-361, 1986. Edman J, Sobel JD: Zinc status in women with recurrent vulvovaginal candidiasis. Am J Obstet Gynecol 155:1082-1085, 1986. Sobel JD: Recurrent vulvovaginal candidiasis: a prospective study of the efficacy of maintenance ketoconazole therapy. N Engl J Med 315:1455-1458, 1986. Jack D. Sobel, M.D.
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Sobel JD, Kaye D: The role of bacterial adherence in urinary tract infections in the elderly. J Gerontology 42:29-32, 1987. Sobel JD, Schmitt CA, Meriwether C: Clotrimazole treatment of recurrent chronic Candida vulvovaginitis. Obstet Gynecol 73:330-334, 1989. Komshian SV, Uwaydah AK, Sobel JD, Crane LR: Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: Frequency, Characteristics, and Evaluation of Factors Influencing Outcome. Rev Inf Dis 11(3):379-390, 1989. Reinhart HH, Obedeanu N, Walz D, Sobel JD: A new ELISA method for the rapid quantification of Tamm Horsfall protein in urine. Am J Clin Path 92:199-205, 1989. Cook RL, Reid G, Pond DG, Schmitt CA, Sobel JD: Clue cells in Bacterial Vaginosis: Immunofluorescent identification of adherent Gram-negative bacteria as Gardnerella vaginalis. J Infect Dis 160:490-496, 1989. Finkelstein R, Raz R, Stein H, Reiss D, Peleg H, Merzbach D, Sobel JD: Bone and Joint infections due to Pseudomonas aeruginosa: Clinical aspects and treatment. Israel J Med Sci 25:123-126, 1989. Redondo-Lopez V, Meriwether C, Schmitt CA, Opitz M, Cook RL, Sobel JD: Vulvovaginal candidiasis complicating recurrent bacterial vaginosis. Sex Trans Dis 17:51-53, 1990. Kwon-Chung KJ, Wickes BL, Salkin IF, Kotz HL, Sobel JD: Is Candida stellatoidea disappearing from the vaginal mucosa? J Clin Microbiol 28:600-601, 1990. Redondo-Lopez V, Lynch M, Schmitt CA, Cook RL, Sobel JD: Torulopsis glabrata vaginitis: Clinical Aspects and Susceptibility to Antifungal Agents. Obstet Gynecol 76:651-655, 1990. Schmitt CA, Meriwether C, Sobel JD: Comparison of 0.8% and 1.6% Terconazole in Severe Candida Vaginitis. Obstet Gynecol 76:414-416, 1990. Reinhart H, Obedeanu N, Sobel JD: Quantitation of Tamm-Horsfall Protein Binding to Uropathogenic Escherichia coli and Lectins. J Infect Dis 162:1335-1340, 1990. Reinhart H, Obedeanu N, Hooton T, Stamm W, Sobel JD: Urinary excretion of Tamm-Horsfall Protein in women with recurrent urinary tract infections. J Urol 144:1185-1187, 1990. Jack D. Sobel, M.D.
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Sobel JD, Schmitt CA, Meriwether C: Slide Latex Agglutination Test in diagnosis of Candida vaginitis. Am J Clin Pathol 94:323-325, 1990. Sobel JD, Vazquez J: Candidemia and systemic candidiasis. Sem Respir Infect 5(2):123-137, 1990. Walsh TJ, Hathorn JW, Sobel JD, Merz WG, Sanchez V, Maret SM, Buckley HR, Pfaller MA, Schaufele R, Sliva C, Navarro E, Lecciones J, Chandrasekar PH, Lee J, and Pizzo PA: Detection of circulating Candida Enolase by immunoassay in patients with cancer and invasive candidiasis. N Engl J Med 324(15):1026-1031, 1991. Reinhart H, Obedeanu N, Merzbach D, and Sobel JD: Effect of Tamm-Horsfall Protein on Chemoluminescence response of polymorphonuclear leukocytes to uropathogenic Escherichia coli. J Infect Dis 164:404-406, 1991. Vazquez JA, Beckley A, Sobel JD, Zervos MJ: Comparison of restriction enzyme analysis and pulsed-field gradient gel electrophoresis as typing systems for C. albicans. J Clin Micro 29:962-967, 1991. Reinhart H, Obedeanu N, Kaye D, Korzenowski O, Sobel JD: Urinary excretion of Tamm Horsfall Protein in elderly women. J Urol 146(3):806-808, 1991. Sobel JD: Treatment of recurrent vulvovaginal candidiasis with maintenance fluconazole. Int J Obstet Gynecol 37:17-34, 1992. Sobel JD: Azole resistance in chronic Candida vaginitis. Int J Obstet Gynecol 37:39-43, 1992. Cook RL, Redondo-Lopez V, Schmitt C, Meriwether C, Sobel JD: Clinical, microbiological, and biochemical factors in recurrent bacterial vaginosis. J Clin Micro 30:870-877, 1992. Schmitt CA, Sobel JD, Meriwether C: Bacterial vaginosis: Treatment with clindamycin cream versus oral metronidazole. Obstet Gynecol 79:1020-1023, 1992. Sanchez V, Vazquez J, Barth-Jones D, Dembry L, Sobel JD, Zervos M: Epidemiology of nosocomial acquisition of Candida lusitaniae. J Clin Micro 30:3005-3008, 1992. Reinhart H, Spenser J, Zaki NF, Sobel JD: Quantitation of urinary Tamm-Horsfall protein in Jack D. Sobel, M.D.
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children with urinary tract infection. European Urology 22:194-199, 1992. Anaissie E, Gokaslan A, Hachem R, Rubin R, Griffin G, Robinson R, Sobel JD, Bodey G: Azole therapy for trichosporonosis: Clinical evaluation of eight patients, experimental therapy for murine infection and review. Clin Infect Dis 15:781-87, 1992. Sanchez V, Vazquez JA, Barth-Jones D, Dembry L, Sobel JD, Zervos MJ: Nosocomial acquisition of Candida parapsilosis: An epidemiologic study. Am J Med 94:577-582, 1993. Sobel JD, Vazquez J, Lynch M, Meriwether C, Zervos MJ: Vaginitis due to Saccharomyces cerevisiae. Epidemiology, clinical aspects and therapy. Clin Infect Dis 16:93-99, 1993. Sobel JD, Schmitt CA, Meriwether C: Long term outcome of treatment of bacterial vaginosis, treated with metronidazole and clindamycin. J Infect Dis 167:783-784, 1993. Fidel PL Jr, Lynch ME, Sobel JD: Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis. Infect Immun 61:4202-4207, 1993. Finkelstein R, Brown P, Palutke WA, Wentworth BB, Geiger JG, Bostic GD, Sobel JD: Diagnostic efficacy of a DNA probe in pneumonia caused by Legionella species. J Med Microbiol 38:183-186, 1993. Vazquez JA, Dmuchowski C, Dembry L, Sanchez V, Sobel JD, Zervos MJ: Nosocomial acquisition of Candida albicans: An epidemiologic study. J Infect Dis 168:195-201, 1993. Lynch ME, KuKuruga M, Nakeff A, Fidel PL, Sobel JD: Flow cytometric analysis of germ tube formation in Candida albicans. J Med Vet Mycol 31:367-376, 1993. Vazquez JA, Beckley A, Donabedian S, Sobel JD, Zervos MJ: Comparison of Restriction Enzyme Analysis versus pulsed-field gradient gel electrophoresis as a typing system for Torulopsis glabrata and Candida species other than C. albicans. J Clin Microb 31(8):2021-2030, 1993. Fidel PL Jr, Lynch ME, Rendondo-Lopez V, Sobel JD, Robinson R: Systemic Cell-mediated immune reactivity in women with recurrent Vulvovaginal Candidiasis. J Infect Dis 168:1458-1465, 1993. Fidel PL Jr, Lynch ME, Sobel JD: Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect Immun 61:1990-1995, Jack D. Sobel, M.D.
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Fidel PL Jr, Lynch ME, Sobel JD: Effects of preinduced Candida-specific systemic cell mediated immunity (CMI) on experimental vaginal candidiasis. Infect Immun 62:1032-1038, 1994. Sobel JD, Schmitt C, Stein G, Mummaw N, Christensen S, Meriwether C: Initial management of recurrent vulvovaginal candidiasis with oral ketoconazole and topical clotrimazole. J Reproduct Med 39:518-520, 1994. Lynch ME, Sobel JD: Comparative in vitro activity of antimycotic agents against pathogenic vaginal yeast isolates J Med Vet Mycol 32:267-274, 1994. Sobel JD: Desquamative Inflammatory Vaginitis - a new subgroup of purulent vaginitis responsive to topical clindamycin. Am J Obstet Gynecol 171:1215-29, 1994. Vazquez JA, Sobel JD, Demitriou R, Vaishampayan J, Lynch M, Zervos MJ: Karyotyping of Candida albicans isolates obtained longitudinally in women with recurrent vulvovaginal candidiasis. J Infect Dis 170:1566-1569, 1994. Rex JH, Bennett JE, Sugar AM, Pappas PG, van der Horst CM, Edwards JE, Washburn RG, Scheld WM, Karchmer AW, Dine AP, Levenstein MJ, Webb CD, for The Candidemia Study Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group. A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. N Engl J Fidel PL Jr, Lynch ME, Sobel JD: Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity. Infect Immun 63(2)547-553, 1994. Fisher JF, Newman CL, Sobel JD: Yeast in the urine. Solution to a budding problem. Clin Infect Dis 20:183-189, 1995. Sobel JD, Brooker D, Stein GE, Thomason JL, Wermeling DP, Weinstein L, Gilbert G, Pancorbo S: Single oral dose fluconazole compared with conventional topical therapy of Candida vaginitis. Am J Ob Gyn 172:1263-8, 1995. Fidel PL, Jr., Lynch ME, Sobel JD: Circulating CD4 and CD8 T cells have little impact on host defense against experimental vaginal candidiasis. Infect Immun 63:2403-2408, 1995. Jack D. Sobel, M.D.
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Geiger A, Foxman B, Sobel JD: Recurent Vulvovaginal Candidiasis: Characteristics of women with Candida albicans, C. glabrata and no Candida. Genitourinary Medicine 71:304-307, 1995. Nyirjesy P, Vazquez JA, Ufberg D, Sobel JD, Jordan CA, Buckley HR: Saccharomyces cerevisiae vaginitis: Transmission from yeast used in baking. Obstet Gynecol 86:326-329, 1995. Pappas PG, Kauffman CA, Perfect J, Johnson PC, McKinsey DS, Bamberger DM, Hamill R, Sharkey PK, Chapman SW, Sobel JD: Alopecia associated with fluconazole therapy. Ann Int Med 123(5):354-357, 1995. Vazquez JA, Lynch M, Sobel JD: In vitro activity of a new Pneumocandin antifungal agents, L-733,560, against azole-susceptible and resistant Candida and Torulopsis species. Antimicrob Ag Chemother 39:2689-2691, 1995. Fidel PL Jr, Cutright JL, Sobel JD. A murine model of Candida glabrata vaginitis. J Infect Dis 173:425-431, 1996. Sobel JD, Chaim W: Tamoxifen associated vulvovaginal candidiasis. Obstet Gynecol 88(Suppl 4):704-706, 1996. Sobel JD, Chaim W, Thomason J, et al: Comparative study of intravaginal Metronidazole and triple sulfa (Sultrin) therapy of bacterial vaginosis. Infect Dis Obstet Gyne 4:66-70, 1996. Dan M, Sobel JD: Trichomoniasis in a Chronic Vaginitis Clinic. Infect Dis Obstet Gynecol 4:77-84, 1996. Chaim W, Meriwether C, Gonik B, Quareshi F, Sobel JD: Vulvar vestibulitis subjects undergoing surgical intervention: Descriptive analysis and histopathologic correlates. Eur J Ob Gyn 68:165-168, 1996. Sobel JD, Chaim W. Vaginal microbiology of women with acute recurrent vulvovaginal candidiasis. J Clin Micro 34:2497-2502, 1996. Lynch ME, Sobel JD, Fidel PL Jr. The role of antifungal drug resistance in the pathogenesis of recurrent vulvovaginal candidiasis. J Med Vet Mycol 34:337-339, 1996. Jack D. Sobel, M.D.
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Schwebke JR, Hillier SL, Sobel JD, McGregor JA, Sweet RL. Validity of the vaginal Gram stain in diagnosis of bacterial vaginosis. Obstet Gyne 88:573-576, 1996. Foxman B, Zhang L, Tallman P, Andrea BC, Geiger AM, Koopman JS, Gillespie BW, Palin KA, Sobel JD, Rose CK: Transmission of uropathogens between sex partners. J Infect Dis 175:989-992, 1997. Schuman P, Capps L, Peng G, Vazquez JA, El-Sadr W, Goldman AI, Alston B, Besch CL, Cobb MN, Vaughn A, Thompson MA, Sobel JD. Prevention of mucosal candidiasis in women infected with the human immunodeficiency virus (HIV). A randomized, double-blind study comparing weekly fluconazole prophylaxis with placebo. Ann Int Med 126:689-696, 1997. Vazquez JA, Lynch M, Boikov D, Sobel JD. In vitro activity of a new penumocondin antifungal L-743,872 against azole-susceptible and resistant Candida species. Antimicrob Ag Chemother 41:1612-1614, 1997. Steffan P, Vazquez JA, Boikov D, Xu C, Sobel JD, Skins RA. Identification of Candida species by randomly amplified polymorphic DNA (RAPD) finger printing of colony lysates. J Clin Micro 35:2031-2039, 1997. Sobel JD, Chaim W. Therapy of T. glabrata vaginitis: Retrospective review of boric acid therapy. Clin Infect Dis 24:649-652, 1997. Fidel PL Jr, Cutright JL, Sobel JD. Efficacy of D0870 treatment of experimental Candida vaginitis. Antimicrobial Ag Chemother 41:1455-1459, 1997. Van der Horst CM, Saag MS, Cloud GA, Hamill RJ, Graybill JR, Sobel JD, et al. Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. N Engl J Med 337:15-21, 1997. Fidel PL Jr, Ginsburg KA, Cutright JL, Wolf NA, Leaman D, Dunlap K, Sobel JD. Vaginal associated immunity in women with recurrent vulvovaginal candidiasis. Evidence for vaginal TH1 response following intravaginal challenge with Candida antigen. J Infect Dis 176:728-739, 1997. Chaim W, Foxman B, Sobel JD. Association of recurrent vaginal candidiasis and secretory Jack D. Sobel, M.D.
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ABO and Lewis phenotype. J Infect Dis 176:828-830, 1997. Lockhart SR, Joly S, Pujol C, Sobel JD, Pfaller MA, Soll DO: Development and verification of fingerprinting probes for Candida glabrata. Microbiol 143:3733-3746, 1997. Vazquez J, Dembry LM, Sanchez V, Vazquez MA, Sobel JD, Dmuchowski C, Zervos MJ: Nosocomial acquisition of Torulopsis glabrata: an epidemiologic study. J Clin Microbiol 36:421-426, 1998. Fessler RD, Sobel JD, Guyot L, Crane L, Vazquez J, Szuba MJ, Diaz FG. Management of elevated intracranial pressure in patients with Cryptococcal meningitis. J AIDS & Human Retro. 17:137-142;1998 Vazquez JA, Arganoza MT, Boikov D, Yoon S, Sobel JD, Akins RA. Stable phenotypic resistance of Candida albicans to amphotericin B confirmed by pre-exposure to subinhibitory levels of azoles. J Clin Micro 36:2690-2695, 1998. Nyirjesy P, Sobel JD, Weitz V, Leaman DJ, Gelone SP. Difficult-to-treat trichomoniasis: Results with paromomycin cream. Clin Infect Dis 26:986-988, 1998. Schuman P, Sobel JD, Ohmit SE, Mayer KH, Carpenter CCJ, Rompalo A, Duerr A, Smith DK, Warren D, Klein RS. Mucosal candidal colonization and candidiasis in women with or at risk for HIV infection. Clin Infect Dis 27:1161-1167, 1998. Foxman B, Marsh JV, Gillespie B, Sobel JD. Frequency and response to vaginal symptoms among white and black women: Results of a random digital dialing survey. J Women’s Health 7:11-67-1174, 1998. Schuman P, Ohmit S, Sobel JD, Mayer KH, Greene V, Rompalo A, Klein RS. Oral lesions among women living with or at risk for HIV. Am J Med 104:559-574, 1998. Saag M, Cloud GA, Graybill JR, Sobel JD, et al. A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associate Cryptococcal meningitis. Clin Infect Dis 28:291-296, 1999. Klein RS, Sobel JD, Flanigan T, Smith D, Margolick JB and the HIV Epidemiology Research Study Group. Stability of cutaneous anergy in women with or at risk for HIV infection. J Acquired Imm Def Synd and Human Retrovir 20:238-244, 1999. Jack D. Sobel, M.D.
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Vazquez JA, Sobel JD, Peng G, Steele-Moore L, Schuman P, Holloway W, Neaton J for the Terry Beirn Community Program for Clinical Research in AIDS (CPCRA). Evolution of vaginal Candida species recovered from HIV-infected women receiving fluconazole prophylaxis: the emergence of Candida glabrata?. Clin Infect Dis 28:1025-1031, 1999. Ben-Josef AV, Manavathu EK, Platt D, Sobel JD. Involvement of calcium inhibitable binding to the cell wall in the fungicidal activity of CAN-296. J Antimicrob Chemo 44:217-222, 1999. Silverman J, Vazquez JA, Sobel JD, Zervos MJ. Comparative in vitro activity of antiseptics and disinfectants versus clinical isolates of Candida species. Infect Control & Hosp Epidemiol 20:676-684, 1999. Sarma AV, Foxman B, Bagirli B, Haefner H, Sobel JD. Epidemiology of vulvar vestibulitis syndrome: an exploratory case control study. Sex Trans Infect 75:320-326, 1999. Yoon SA, Vazquez JA, Steffan PE, Sobel JD, Akins RA. High frequency, in vitro reversible switching of Candida lusitaniae clinical isolates from amphotericin B-susceptible to resistance. Antimicrob Agents Chemother 43:836-45, 1999. Sobel JD, Kauffman CA, McKinsey D, Zervos D, Vazquez JA, Panzer H, Dismukes W. Candiduria in a randomized double blind study of treatment with fluconazole and placebo. Clin Infect Dis 30:19-24, 2000. Graybill JR, Sobel JD, Saag M, VanderHorst C, Powderly W, Cloud G, Riser L, Hamill R, Dismukes W. Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. Clin Infect Dis 30:47-54, 2000. Kauffman C, Vazquez JA, Sobel JD, Gallis HA, McKinsey DS, Karchmer AW, Sugar AM, Sharkey PK, Wise GJ, Mangi R, Mosher A, Lee JY, Dismukes WE, and the NIAID Mycoses Study Group A prospective multicenter surveillance study of funguria in hospitalized patients. Clin Infect Dis 30:14-18, 2000. Manavathu EK, Ben-Josef AV, Sobel JD. Proton translocating ATPase mediated fungicidal activity of a novel complex carbohydrate: CAN-296. Internat J Antimicrob Ag 13:287-295, 2000. Foxman B, Barlow R, d’Arcy H, Gillespie B, Sobel JD. Candida vaginitis: self-reported incidence and associated costs. Sex Trans Dis 27:230-235, 2000. Jack D. Sobel, M.D.
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Foxman B, Gillespie B, Koopman J, Zhang L, Palin K, Tallman P, Marsh JV, Spear S, Sobel JD, Marty MJ, Marrs CF. Risk factors for second urinary tract infection among college women. Am J Epidemiol 151(12):1194-1205, 2000. Klein RS, Smith D, Sobel JD, Flanigan T, Margolick JB. A prospective study of positive tuberculin reactions in women with or at risk for HIV infection. International J TB and Lung Dis 4:688-690, 2000. Foxman B, Barlow R, d’Aray H, Gillespie B, Sobel JD. Urinary Tract Infection: Self-reported incidence and associated costs. Ann. Epidemiol 10:509-515, 2000. Sobel JD, Ohmit SE, Schuman P, Klein RS, Mayer K, Duerr A, Vazquez JA, Rompalo A. The evolution of Candida species and fluconazole susceptibility among oral and vaginal isolates recovered from HIV seropositive and at-risk HIV-seronegative women. J Infect Dis 183:286-293, 2001 Leigh JE, Barousse M, Myers T, Swoboda R, Hager S, Wolf NA, Cutwright JL, Thompson J, Sobel JD, Fidel PL Jr. Candida-specific systemic cell-medicated immune reactivities in HIV-infected persons with mucosal candidiasis. J. Infect. Dis. 183:277-285, 2001. Nyirjesy P, Sobel Weitz V, Leaman D, Small MJ, Gelone SP. Cromolyn cream for recalcitrant idiopathic vulvar vestibulities: Results of a placebo-controlled study. Sex Trans. Inf. 77:53-57, 2001 Foxman B, Somsel P, Tallman P, Gillespie B, Raz R, Colodner R, Kandula D, Sobel, JD. Urinary tract infection among women aged 40-65: Behavioral and sexual risk factors. J. Clin. Epidem 54:710-718, 2001 Sobel JD, Peipert JF, McGregor JA, Livergood C, Martin M, Robbins J, Wajszczuk CP. Efficacy of clindamycin vaginal ovule (3 day treatment) vs. Clindamycin vaginal cream (7 day treatment) in bacterial vaginosis. Infect. Dis. Obstet. Gynecol. 9:9-15, 2001 Warren D, Klein RS, Sobel JD, Kieke B Jr, Brown W, Schuman P, Anderson J, CuUvin S, Mayer K, Jamieson DJ, Holmberg S, Duerr A. A multicenter study of bacterial vaginosis in women with or at high risk for HIV infection. Infect. Dis. Obstet. Gynecol. 9:133-142, 2001. Vazquez JA, Peng G, Sobel JD, Steele-Moore L, Schuman P, Holloway W, Neaton JD. Evolution of antifungal susceptibility among Candida species isolates recovered from Jack D. Sobel, M.D.
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human immunodeficiency virus-infected women receiving fluconazole prophylaxis. Clin. Inf. Dis. 33:1069-75, 2001. Sobel JD, Kapernick PS, Zervos M, Reed BD, Hooton T, Soper D, Nyirjesy P, Heine MW, Willems J, Panzer H, Wittes H. Treatment of complicated Candida vaginitis; Comparison of single and sequential doses of fluconazole. Am. J. Obstet. Gynecol. 185:363-69, 2001. Sobel JD, Nyirjesy P, Brown W. Metronidazole-resistant trichomoniasis: Treatment with tinidazole. Clin. Infect. Dis. 33:1341-6, 2001. Jamieson DJ, Duerr A, Klein RS, Paramsothy P, Brown W, Cu-Uvin S, Rompalo A, Sobel JD. Incidence, persistence and severity of bacterial vaginosis and disturbances in vaginal flora among women with or at high risk for HIV. Obstet. Gynecol. 98:656-63, 2001. Barousse MM, Steele C, Dunlap K, Espinosa T, Boikov D, Sobel JD, Fidel PL Jr. Growth inhibition of Candida albicans by human vaginal epithelial cells. J. Inf. Dis. 184:1489-93, 2001 Ferris DG, Nyirjesy P, Sobel JD, Soper D, Pavletik A, Litaker MS, Foxman B. Over-ther-counter antifungal product misuse associated with patient diagnosed vulvovaginal candidiasis. Obstet. Gynecol. 99:419-425, 2002 DeLeon EM, Jacober SJ, Sobel JD, Foxman B. Prevalence and risk factors for vaginal Candida colonization in women with type I and II diabetes. BMC Infectious Dis. 2:1-11, 2002 Park JC, Buono D, Smith DK, Peipert JF, Sobel J, Rompalo A, Klein RS. Urinary tract infections in women with or at risk for HIV infection. Am. J. Obstet. Gynecol. 187:581-8, 2002 Newbern EC, Foxman B, Leaman D, Sobel JD. Desquamative inflammatory vaginitis: An exploratory case-control study. Ann. Epidemiol. 12:346-352, 2002 Singh S, Sobel JD, Bhargava P, Boikov D, Vazquez JA. Vaginitis due to C. krusei. Epidemiology, clinical aspects and therapy. Clin. Infect. Dis. 35:1066-70, 2002 Foxman B, Manning SD, Tallman P, Bauer R, Zhang L, Koopman JS, Gillespie B, Sobel JD, Marrs CF. Uropathogenic Escherichia coli are more likely than commensal E. coli to be shared between heterosexual sex partners. Am. J. Epidemiol. 156:1133-40, 2002 Jack D. Sobel, M.D.
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Sobel JD, Zervos M, Reed BD, Hooton T, Soper D, Nyirjesy P, Heine MW, Willems J, Panzer H. Fluconazole susceptibility of vaginal isolates obtained from women with complicated Candida vaginitis: clinical implications. Antimicrob. Agents Chemother. 47:34-8, 2003 Duerr A, Klein R, Meikle S, Sobel JD, Rompalo A, Cu-Uvin S, Heilig S. Incident and persistent vulvovaginal candidiasis among HIV-infected women. Risk factors and severity. Obstet. Gynecol. 101:548-556, 2003 Rex JH, Pappas PG, Karchmer AW, Sobel JD, Edwards J, Hadley S, Brass C, Vazquez JA, Chapman SW, Horowitz HW, Zervos M, McKinsey D, Gell J. A randomized and blinded multicenter trial of high-dose fluconazole plus placebo vs. fluconazole plus amphotericin B as therapy of candidemia and its consequences in non-neutropenic subjects. Clin. Infect. Dis. 36:1221-8, 2003 Ohmit S, Sobel JD, Klein R, Schuman P, Duerr A, Rompalo A. A longitudinal study of mucosal Candida colonization and candidiasis among HIV-seropositive and at-risk-HIV-seronegative women. J. Infect. Dis. 188:118-127, 2003 Ben-Josef AM, Cutright JL, Manavathu EK, Sobel JD. CAN-296-P is effective against cutaneous candidiasis in guinea pigs. Int J Antimicrob Agents. 22:168-71, 2003 Makela P, Sobel JD, Leaman D. Vulvovaginal Trichosporonosis. Infectious Diseases in Ob/Gyn 11:131-132, 2003 Sobel JD, Chaim W, Nagappan V, Leaman D. Treatment of vaginitis caused by Candida glabrata: use of boric acid and flucytosine. Am J Obstet Gynecol 189:1297-300, 2003 Moosa MY, Sobel JD, Elhalis H, Du W, Akins RA. Fungicidal activity of fluconazole against Candida albicans in a synthetic vagina simulative medium. Antimicrobial Agents Chemo 38:161-7, 2004 Patel D, Sobel JD, Leaman D, Nyirjesy P, Foxman B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Amer J Obstet Gynecol 190:644-53, 2004 Du W, Coaker M, Sobel JD, Akins RA. Shuttle vectors for Candida albicans: control of plasmid copy number and elevated expression of cloned genes. Curr Genet 45:390-8, 2004 Jack D. Sobel, M.D.
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Sobel JD, Wiesenfeld HC, Martens M, Danna P, Hooton TM, Rompalo A, Sperling M, Livengood C, Horowitz B, Von Thron J, Edwards L, Panzer H, Chu T-C. A randomized, placebo-controlled trial of maintenance fluconazole therapy for management of recurrent vulvovaginal candidiasis. N Eng J Med 351:876-83, 2004. Ghanem KG, Shah N, Klein RS, Mayer KH, Sobel JD, Warren DL, Jamieson DJ, Duerr AC, Rompalo AM for the HIV Epidemiology Research Study (HERS) Group. The Influence of Sex Hormones, HIV Status and Concomitant Sexually Transmitted Infection on Cervicovaginal Inflammation. J Infect Dis 191:358-66, 2005. Goldman M, Cloud GA, Wade KD, Reboli AC, Fichtenbaum CJ, Hafner R, Sobel JD, Powderly WG, Patterson TF, Wheat LJ, Stein DK, Dismukes WE, Filler SG; AIDS Clinical Trials Group Study Team 323; Mycoses Study Group Study Team 40. A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40. Clin Infect Dis. 41:1473-80, 2005 . Viscidi RP, Snyder B, Cu-Uvin S, Hogan JW, Clayman B, Klein RS, Sobel J, Shah KV. Human papillomavirus capsid antibody response to natural infection and risk of subsequent HPV infection in HIV-positive and HIV-negative women. Cancer Epidemiol Biomarkers Prev 14:383-8, 2005. Kullberg BJ, Sobel JD, Ruhnke M, Pappas PG, Viscoli C, Rex JH, Cleary JD, Rubinstein E, Church LW, Brown JM, Schlamm HT, Oborska IT, Hilton F, Hodges MR. Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial. Lancet. 366:1435-42, 2005. 161. Sobel JD, Ferris D, Schwebke J, Nyirjesy P, Wiesenfeld H, Peipert J, Soper D, Ohmit SE, Hillier S. Suppressive antibacterial therapy with 0.75 % metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Amer J Obstet Gynecol 194:1283-9, 2006. 162. Bornstein J, Geva A, Solt I, Fait V, Schoenfeld A, Shoham HK, Sobel J. Nonintrusive diagnosis of premature ruptured amniotic membranes using a novel polymer. Am J Perinatol. 23:351-4, 2006. 163. Geva A, Bornstein J, Dan M, Shoham HK, Sobel JD. The VI-SENSE-vaginal discharge self-test to facilitate management of vaginal symptoms. Am J Obstet Gynecol. 195:1351-6, 2006. Jack D. Sobel, M.D.
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164. Sobel JD, Bradshaw SK, Lipka J, Kartonis NA. Caspofungin in the treatment of symptomatic candiduria. Clin Infect Dis 44:e46-9, 2007. 165. Livengood CH, Ferris DG, Wiesenfeld HC, Hillier SL, Soper DE, Nyirjesy P, Manazzo J, Chatwani A, Fine P, Sobel JD, Taylor SN, Wood L, Kanalas JJ. Effectiveness of two tinidazole regimens in treatment of bacterial vaginosis. A randomized control trial. Obstet Gynecol 110, 302-309, 2007 166.Ostrosky-Zeichner L, Sable C, Sobel JD, Alexander BD, Dorowitz G, Kan V, Kauffman CA, Kett D, Larsen RA, Morrison V, Nucci M, Pappas PG, Bradley ME, Major S, Zimmer L, Wallace D, Dismukes WE, Rex JH. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Micro Infect Dis 26:271-6, 2007. 167.Xu J, Schwartz K, Bartoces M, Monsur J, Severson RK, Sobel JD. Effect of antibiotics
on vulvovaginal candidiasis: a MetroNet study. J Am Board Fam Med 21:261-8,
2008.

168.Salimnia H, Noronha A, Sobel JD, Fairfax MR. Sepsis associated with a new
Atopobium species, provisionally named Atopobium detroiti: case report and
review of the current status of the species Atopobium. Scand J Infect Dis 40:679-81,
2008.

169.De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Sobel JD, et al. Revised
definitions of invasive fungal disease from the European Organization for Research
and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the
National Institute of Allergy and Infectious Diseases Mycoses Study Group
(EORTC/MSG) consensus Group. Clin Infect Dis. 46:1813-21, 2008

170.Segal BH, Herbrecht R, Stevens DA, Ostrosky-Zeichner L, Sobel J, Viscoli C, Walsh
TJ, Maertens J, Patterson TF, Perfect JR, Dupont B, Wingard JR, Calandra T,
Kauffman CA, Graybill JR, Baden LR, Pappas PG, Bennett JE, Kontoyiannis DP,
Cordonnier C, Viviani MA, Bille J, Almyroudis NG, Wheat LJ, Graninger W, Bow
EJ, Holland SM, Kullberg BJ, Dismukes WE, De Pauw BE. Defining responses to
therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses

Jack D. Sobel, M.D.
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Study Group and European Organization for Research and Treatment of Cancer
consensus criteria. Clin Infect Dis 47:674-83, 2008.

171.Schuster MG, Edwards JE Jr, Sobel JD, Darouiche RO, Karchmer AW, Hadley S,
Slotman G, Panzer H, Biswas P, Rex JH. Empirical fluconazole versus placebo for
intensive care unit patients: a randomized trial. Ann Intern Med 149:83-90, 2008.

172.Bachow K, Zmily H, Kizilbash M, Awad K, Hourani R, Hammad H, Sobel JD, Ghalli JK, Louvre D, Alfonso L. Vascular perforation in left-sided native valve endocarditis. J Clin Cardiol 2009 (In press) 173.Pappas PG, Chetchotisakd P, Lovsen RA, Morosuthi W, Morris MI, Nolen TL, Zimmer LO, Kendrick AS, Johnson P, Sobel JD, Filler SG. A phase II randomized trial of amphotericin B alone or combined with fluconazole in treatment of HIV-associated Cryptococcal meningitis. Clin Infect Dis 2009 (in press) Review Articles
1.
Sobel JD: Advances in venous thrombosis. S African Med J 47:1197-1202, 1973. Sobel JD: Recurrent Candida vaginitis: a rational approach to therapy. Drug Therapy 12:14-55, 59-61, 1982. Sobel JD: Clinical approach to genital Herpes Simplex virus infections. Current Topics in Emergency Med 3:1-4, 1984. Finkelstein R, I Levi, and JD Sobel: Culture negative endocarditis. Drug Therapy 9:43-49, 1984. Sobel JD and D Kaye: Host factors in the pathogenesis of urinary tract infection. Am J Med, May (Suppl):122-130, 1984. Sobel JD: Recurrent vulvovaginal candidiasis, what we know and what we don't (editorial). Ann Intern Med 101:390-392, 1984. Sobel JD: Pathogenesis of vulvovaginal candidiasis. Symposium Proc Med Foundation: Oxford University, 1984, pp 1-13. Sobel JD: Vaginal infection. Current Topics in Emergency Medicine 2:9, 1985. Jack D. Sobel, M.D.
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Sobel JD: Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis. Am J Ob Gyn 152:924-934, 1985. Sobel JD: New aspects of pathogenesis of lower urinary tract infections. Urology 26(Suppl 5):11-16, 1985. Reid G and JD Sobel: Bacterial adherence in the pathogenesis of urinary tract infection. Rev Infect Dis 9:470-487, 1987. Sobel JD: Epidemiology and pathogenesis of vulvovaginal candidiasis. Ann NY Academy of Sciences, 544:547-557, 1988. Sobel JD: Management of recurrent vulvovaginal candidiasis. Infect Med, 5:429-436, 1988. Sobel JD: When candidal vaginitis warrants systemic treatment. Contemporary OB-GYN., 31(2):73-77, 1988. Sobel JD: Pathophysiology of vulvovaginal candidiasis. J Reproduct Med 34(8):572-580, 1989. Sobel JD: New insights in the pathogenesis of vaginal candidosis. Internat. J Exp Clin Chemo 2(Suppl 1):9-18, 1989. Sobel JD: Bacterial Vaginosis an Ecologic Mystery. Ann Int Med 111:551-553, 1989. Reinhart HH, JD Sobel: Cytomegalovirus Pneumonia in Bone Marrow Transplant Patients. Immunity, April 14-18, 1990. Sobel JD: Therapeutic dilemmas in Bacterial Vaginosis. Infect Med May 24-30, 1990. Redondo-Lopez V, RL Cook, JD Sobel: Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev Infect Dis 12:856-871, 1990. Sobel JD: Bacterial Vaginosis: Assessment and treatment. Medical Aspects of Human Sexuality June 50-54, 1990. Sobel JD: Individualizing treatment of Vaginal Candidiasis. J Am Acad Dermatol 23:572-576, 1990. Sobel JD: Bacterial Cystitis: Conventional versus short-term therapy (In press), 1992. Jack D. Sobel, M.D.
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Sobel JD: Pathogenesis and treatment of recurrent vulvovaginal candidiasis. Clin Infect Dis 14(Suppl):148-153, 1992. Oren I, Sobel JD: Human Herpes Virus 6: A Review. Clin Infect Dis. 14:741-746, 1992. Sobel JD: Bacterial Vaginosis. Bulletin of Sexually Transmitted Diseases 7:325, 1992. Reinhart R, Sobel JD: The role of Tamm-Horsfall protein in the pathogenesis of urinary tract infection. Int. Urogynecol 3:191-196, 1992. Sobel JD: Use of prophylactic antifungal agents in the ICU. Clinical consultant answer to clinical queries. J Critical Care, 7:325, 1992. Sobel JD: Vulvovaginal candidosis. Medicine International 21(4):140-143, 1993. Sobel JD: Candidal vulvovaginitis. Clin Obstet Gynecol 36:153-166, 1993. Peppercorn MA, Shelley ED, Sobel JD: Metronidazole: Versatile antimicrobial. Patient Care 137-143, 1993. Sobel JD, Schuman P: Vaginitis in HIV-Infected Women. Opportunistic Complications of HIV, Menicus Limited 2(2):28-36, 1993. Schuman P, Sobel JD: Women and AIDS. The Austr New Zealand J Obstet Gynecol 33:341-350, 1993. Sobel JD: Surveillance cultures for fungi: Expensive - and not the standard of care. J Critical Illness 8(1):23-24, 1993. Sobel JD: The missing piece in the complex puzzle of UTIs?. Infect Med 10(10):19-20, 1993. Bailey EM, Sobel JD: Update on the prophylaxis, diagnosis and treatment of candidal infections in hospitalized patients. Hosp Formul 28:914-932, 1993. Fidel PL Jr, Sobel JD: The role of cell-mediated immunity in candidiasis. Trends in Microbiol 2:202-206, 1994. Sobel JD: Vulvovaginal Candidiasis: A mini-review. Infect Dis Clin Pract 3:334-340, Jack D. Sobel, M.D.
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Sobel JD: Controversial aspects in the management of vulvovaginal candidiasis. J Am Acad Dermatol 31(Suppl):10-13, 1994. Sobel JD: Management of Vaginosis: Prevention and treatment. Drug Invest. 8(Suppl 1):26-34, 1994. Sobel JD: Clinical caveats in the treatment of Vulvovaginal candidiasis. Mycology 42-46, 1995. Reef S, Levine W, McNeil M, Fisher-Houch S, Sobel JD, Smith D, Holmberg S, Duer A, Pinner R: Treatment options for vulvovaginal candidiasis. Background paper for development of 1993 STD treatment recommendations. Clin Infect Dis 20(Suppl):80-90, 1995. Sobel JD: Treating resistant vaginal infections. The Female Patient 20:32-46, 1995. Reef S, McNeil M, Sobel JD, Pinner R: Vulvovaginal candidiasis: A review of available therapeutic options. Infect Dis Clin Pract 4:36-40, 1995. Fidel PL Jr, Sobel JD: Immunopathogenesis de la candidose vulvovaginale recurrente (CVVR). Contracept Fertil Sex 24:33-40, 1996. Sobel JD: Trouble ahead for patients with chronic mucocutaneous candidiasis (CMC). Editorial. Infect Dis Clin Pract 5:140-142, 1996. Sobel JD. Vaginitis and vaginal flora: controversies abound. Curr Opin Infect Dis 9:42-47, 1996. Fidel PL Jr, Sobel JD: Immunopathogenesis of recurrent vulvovaginal candidiasis. Clin Micro Reviews 9:335-348, 1996. Sobel JD, Chaim W: Update on treatment of vulvovaginal candidiasis. Revista Iberoamericana de Micologia 13:44-46, 1996. Sobel JD, Fidel PL Jr: Update of the pathogenesis of mucosal candidiasis - lessons from vaginal candidiasis. Proceedings of the 5th Symposium on Topics in Mycology: Host Fungus Interplay, National Foundation for Infectious Diseases 3-11, 1997. Sobel JD: Diagnosis and management of vaginal discharge. Contemporary Internal Jack D. Sobel, M.D.
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Sobel JD: Vaginitis. N Engl J Med 337:1896-1903, 1997. Vazquez JA, Sobel JD: Epidemiological overview of resistance to oral antifungal agents in the immunocompromised host. Exerpta Medica Abstracts pp 1-11, 1997. Sobel JD. Recurrent vulvovaginal candidiasis in HIV-infected women. Cliniguide to Fungal Infections. 8:1-5, 1997. Chaim W, Mazor M, Sobel JD. Candida albicans vulvovaginitis Harefuah. J Israel Med Assoc 133;1:40-43, 1997. Sobel JD, Faro S, Force RW, Foxman B, Ledger WJ, Nyirjesy PR, Reed BD, Summers PR: Vulvovaginal candidiasis: epidemiologic, diagnostic and therapeutic considerations. Am J Obstet Gynecol 178:203-211;1998. Sobel JD. A comprehensive strategy for managing recurrent vulvovaginal candidiasis. OBG Management Suppl, Aug 11-21, 1998. Sobel JD, Hasegawa A, De Bernardis F, Adriani D, Pellegrini G, Cassone A, Fidel PL Jr, Haidaris CG, Gigliotti F, et al. Selected animal models: vaginal candidosis, pneumocystitis pneumonia, dermatophytosis and trichosporonosis. Medical Mycology 36:(Suppl 1)129-136, 1998. Fidel PL Jr, Sobel JD. Protective immunity in experimental Candida vaginitis. Research in Immunol, 73rd Forum in Immunol, Immunity to Fungi 149:361-373, 1998. Sobel JD. Vulvovaginitis due to Candida glabrata: An emerging problem. Mycoses 41(Suppl 2):18-22, 1998. Fidel PL Jr, Vazquez JA, Sobel JD. Candida glabrata: Review of epidemiology, pathogenesis and clinical disease. Clinic Micro Review 12:80-96, 1999. Sobel JD. Vulvovaginitis in healthy women. Comprehensive Ther 25:335-346, 1999. Sobel JD: Diagnostic considerations in microscopy-negative Candida vaginitis. Ital J Gynecol Obstet 2:73-78, 1999. Sobel JD: Limitations of antifungal agents in the treatment of Candida vaginitis: future Jack D. Sobel, M.D.
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challenges. Drug Resistance Updates 2:148-153, 1999. Sobel JD: Asymptomatic candiduria, review of treatment. Internat J Antimicrobial Ag 11:285-288, 1999. Sobel JD, Vazquez JA: Urinary tract infections due to fungi. World J of Urology 17:410-4, 1999 Sobel JD: Protective role of vaginal flora. Curr Infect Dis Reports 1:379-383, 1999. Sobel JD: Bacterial vaginosis. Ann Rev Med 51:29-49, 2000. Saag MS, Graybill JR, Larsen RA, Pappas PG, Perfect JR, Powderly WG, Sobel JD, Dismukes WE: Guidelines for the management of cryptococcal disease. Clin Infect Dis 30: 2000 Rex JH, Walsh TJ, Sobel JD, Filler SG, Pappas PG, Dismukes WE, Edwards JE: Practice guidelines for the treatment of candidiasis. Clin Infect Dis 30:662-78, 2000 Sobel JD: Use of antifungal drugs in pregnancy. Drug Safety 23: 77-85, 2000 Sobel JD: Management of infections caused by C. glabrata. Curr Infect. Dis Report 2: 424-428, 2000. Sobel JD: Non trichomonal purulent vaginitis: Clinical approach. Curr Rep Infect Dis 2:501-505, 2000. Sobel JD: Gynecologic infections in HIV seropositive women. Clin Infect Dis 31: 1225-1233, 2000. Tiraboschi N, Bennett JE, Kauffmann CA, Rex JH, Girmenia C, Sobel JD, Menichetti F. Deep Candida infections in the neutropenic and non-neutropenic host. Med. Mycol. 38; 51:199-204, 2000. Sobel JD: Managing vulvovaginal candidiasis. The Female Patient 20:29-45, 2000. Ormerod D, Pucklin J, Sobel JD: Syphilitic posterior uveitis. Correlative findings and significance. Clin. Infect. Dis. 32:1661-1673, 2001. Rex JH, Walsh TJ, Nettleman M, Anaissie EJ, Bennett JE, Bow EJ, Carello-Munge AJ, Jack D. Sobel, M.D.
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Chavanoi P, Cloud GA, Denning DW, De Pauw BE, Edwards JE, Hiemenz, JW, Kauffman CA, Lopez Bernstein G, Martino P,, Sobel JD, Stevens DA, Sylvester R, Tollemar J, Viviani MA, Viscoli C, Wu T. Need for alternative trial designs and evolution strategies for therapeutic studies of invasive mycoses. Clin. Infect. Dis. 33:95-106, 2001. Rex JH, Sobel JD. Prophylactic therapy in the intensive care unit. Clin. Infect. Dis. 32:1191-1200, 2001. Lundstrom T, Sobel JD. Nosocomial candiduria. Clin. Infect. Dis. 32:1602-1607, 2001. Sobel JD, Lundstrom T. Management of candiduria. Curr. Urol. Rep. 2:321-5, 2001. Sobel JD, Epidemiology and management of fungal vaginitis. Rev Med Microbiol 12:(Suppl)S21-S27, 2001. Sobel JD. Antimicrobial resistance in vulvovaginitis. Curr Inf Dis Rep 3:546-49, 2001. Sobel JD. Not a mycologist just Candida. Infect. Dis. Clin. Pract. 10:299-306, 2001. Mead PB, Sobel JD. Eschenbach D. What’s new in vaginitis, diagnosis and treatment? Contemp Ob-Gyn 46:14-47, 2001. Fidel PL Jr, Vazquez JA, Sobel JD. Candida glabrata a new pathogen in the 21st century. Clin. Microbiol. Newsletter. 23:171-176, 2001. Sobel JD. Candida infections in patients infected with HIV. Curr. Treatment Options in I.D. 4:101-107, 2002. Sobel JD. Treatment of vaginal Candida infection. Expert. Opin. Pharmacother. 3:1059-1065, 2002. Moosa YS, Sobel JD. Non-albicans Candida infection in patients with hematological malignancies. Semin Respir Infect 17:91-8, 2002. Sobel JD. Vulvovaginal candidiasis: A comparison of HIV positive and negative women. Internal J of STD and AIDS 13:358-362, 2002. Makela P, Sobel JD. Evaluation and management of vulvar vestibulitis syndrome: A poorly understood disorder. Postgrad. Obstet. Gynecol. 22:1-5, 2002. Sobel JD. Pathogenesis of recurrent vulvovaginal candidiasis. Curr. Infect. Dis. Rep. 4:514- Jack D. Sobel, M.D.
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Vazquez JA, Sobel JD. Mucosal candidiasis. Infect. Dis. Clin. N. Am. 16:793-820, 2002. Sobel JD. Management of patients with recurrent vulvovaginal candidiasis. Drugs 63:1059-1066, 2003 Sobel JD, Vazquez JA. Candidiasis in the ICU. Seminars in Resp. Dis. 24:99-112, 2003 Moudgal VV, Sobel JD. Antifungal drugs in pregnancy: a review. Expert Opin Drug Safe 2:475-83, 2003. Sobel JD. Erosive vaginitis. Clin Infect Dis Reports 5:494-498, 2003. Sobel JD. Estrogen replacement therapy to prevent recurrent urinary tract infections in postmenopausal women. Curr Infect Dis Rep 5:479-480, 2003. Nyirjesy P, Sobel JD. Vulvovaginal candidiasis. Obstet Gynecol Clin North Am 30:671-84, 2003 Xu J, Sobel JD. Antibiotic associated vulvovaginal candidiasis. Clin Infect Dis Reports 5:481-487, 2003. Pappas PG Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, Edwards JE. Guidelines for treatment of candidiasis. Clin Infect Dis 38:161-89, 2004. Cha R, Sobel JD. Fluconazole for the treatment of candidiasis: 15 years experience. Expert Review Anti-Infect Therapy 2:357-366, 2004. Lundstrom TS, Sobel JD. Antibiotics for gram positive bacterial infections. Vancomycin quinupristin/dalfopristin, linezolid and, daptomycin. Infect Dis Clin N Amer 18:651-668, 2004 Rex JH., Wingard R., Wenzel R, Herbrecht R., Sobel JD., Edwards JF Jr. The design of clinical trials evaluating antifungal prophylaxis and combination therapy: Symposium introduction and overview. Clin Infect Dis 39:S165-S169, 2004 Sobel JD. Combination therapy of invasive mycoses – evaluation of past clinical trial design. Clin Infect Dis 39:S224-S227, 2004 Jack D. Sobel, M.D.
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Moudgal V, Sobel JD. Selection of antifungals in renal failure. Current Opinion in Investig Drugs Reviews 5(8):873-878, 2004 Sobel, JD. Diagnostic screening for bacterial vaginosis. Ob/Gyn Spring 2-4, 2004. Xu J, Sobel JD. Candida vulvovaginitis in pregnancy. Curr Infect Dis Rep 6:445-449, 2004. Sobel JD. Current trends and challenges in candidiasis. Oncology (Williston Park). 2004 Dec;18(14 Suppl 13):7-8. Chen A, Sobel JD. Emerging azole antifungals. Expert Opin Emerg Drugs. 10:21-33, 2005. Sobel JD. What's new in bacterial vaginosis and trichomoniasis? Infect Dis Clin North Am. 19:387-406, 2005. Nyirjesy P, Sobel JD. Practical strategies for acute and recurrent vaginitis. OBG Management Aug, pp 20-32, 2005. Nyirjesy P, Sobel JD. Advances in diagnosing vaginitis: development of a new algorithm. Curr Infect Dis Rep. 7:458-62, 2005. Sobel JD. Current treatment options for vulvovaginal candidiasis. J Womens Health 1:253-261, 2005. Chandrasekar PH, Sobel JD. Micafungin: A new echinocandin. Clin Infect Dis 2:1171-8, 2006. Vazquez JA, Sobel JD. Anidulafungin: A novel echinocandin. Clin Infect Dis 43:215-222, 2006 Bachmann GA, Rosen R, Pinn VW, Utian WH, Ayers C, Basson R, Binik YM, Brown C, Foster DC, Gibbons JM Jr, Goldstein I, Graziottin A, Haefner HK, Harlow BL, Spadt SK, Leiblum SR, Masheb RM, Reed BD, Sobel JD, Veasley C, Wesselmann U, Witkin SS. Vulvodynia: a state-of-the-art consensus on definitions, diagnosis and management. J Reprod Med. 51:447-56, 2006. Sobel JD. Design of clinical trials of empiric antifungal therapy in patients with persistent febrile neutropenia: considerations and critiques. Pharmacotherapy. 266:47S-54S, 2006. Review. Jack D. Sobel, M.D.
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Sobel JD. Management of recurrent vulvovaginal candidiasis: unresolved issues. Curr Infect Dis Rep. 8:481-6, 2006. Sobel JD. The emergence of non-albicans Candida species as causes of invasive candidiasis and candidemia. Curr Infect Dis Rep. 8:427-33, 2006. Anaissie EJ, Segal BH, Graybill JR, Arndt C, Perfect JR, Kleinberg M, Pappas P, Benjamin D, Rubin R, Aberg JA, Adderson EE, Adler-Shohet FC, Akan H, Akova M, Almyroudis NG, Alexander BD, Andes D, Arrieta A, Baddley JW, Barron MA, Belzberg H, Boucher HW, Boyce TG, Casadevall A, Chandrasekar PH, Cleary JD, Cordonnier C, Cornely OA, Cuenca-Estrella M, Daly JS, Daoura N, Denning DW, dePauw B, de Repentigny L, Dignani MC, Dismukes WE, Donnelly JP, Donowitz GR, Dupont B, Drusano G, Ellis M, Espinel-Ingroff A, Fishman JA, Fleming R, Forrest G, Ghannoum M, Goldman M, Grazziutti M, Greene JN, Greenberg RN, Gubbins PO, Hadley S, Herbrecht R, Hiemenz JW, Hope W, Hospenthal DR, Husain S, Ito JI, Jacobson RM, Johnson M, Keating MR, Kett DH, Knapp K, Kontoyiannis DP, Krcmery VC, Larsen R, Laverdiere M, Ljungman P, Lortholary O, Maertens J, Marriott D, Mattiuzzi G, McGinnis MR, Morris M, Nucci M, Odds FC, Pankey GA, Patterson T, Pfaller M, Razonable RR, Reboli AC, Rinaldi MG, Roberts GD, Rodriguez Tudela JL, Rotstein C, Ruhnke M, Schuster M, Shoham S, Sia IG, Siebel N, Silviera F, Singh N, Sobel J, Solomkin JS, Sorrell TC, Steinbach WJ, Temesgen Z, Tortorano A, Vartivarian S, VerWeij P, Viscoli C, Viviani MA, Walker RC, Wheat JL, Wiley J, Williamson P, Wingard JR, Yu VL, Zaoutis T. Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt. Clin Infect Dis. 43:1031-9, 2006. Nailor MD, Sobel JD. Progress in antifungal therapy: Echinocandins versus azoles. Drug Discov Today 3:221-226, 2006 Moudgal V, Sobel J. Nosocomial infective endocarditis. Infectious Disease Practice, Nov-Dec, 30;11-12, p 552-554, 2007. Farage N, Bramanto M, Otaka Y, Sobel J. Do panty liners promote vulvovaginal candidiasis or urinary tract infection? A review of the scientific evidence. Eur J Obstet Gynecol; 132:8-19, 2007 Sobel JD. Vulvovaginal candidosis—pathogenesis and treatment. Lancet 369:1961-71, 2007 Nailor MD, Sobel JD. Tinidazole for the treatment of vaginal infection. Expert Opin Invest Jack D. Sobel, M.D.
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Nailor MD, Sobel JD. Tinidazole for bacterial vaginosis. Expert Rev Anti-Infect Ther 5:343-8, 2007 Kalra A, Palai CT, Sobel JD, Akins RA. Bacterial vaginosis: Culture and PCR-based characterization of a complex polymicrobial disease’s pathology. Curr Infect Dis Rep 9:485-500, 2007 Brown P, Sobel JD. Advances in understanding and treatment of complications of
urinary tract infections. Europ Genito-urinary Dis 51-53, 2008

Revankar SG, Nailor MD, Sobel JD. Use of terbinafine in rare and refractory
mycosesFuture Med 3:9-17-17, 2008

Sobel JD, Revankar SG. Candida infections-emerging pathogens non-albicans. In:
Emerging Infections, Scheld M, Hammer SM (Ed), 8:337-355, 2008.

Varghese G, Sobel JD. Fungal endocarditis. Curr Infect Dis Rep. 10:275-279, 2008

Sobel JD, Revankar S, Vazquez J, Ostrosky-Zeichner L. Mucocutaneous candidiasis in
guidelines for prevention and treatment of opportunistic infections in HIV-infected
adult and adolescents. MMWR 57:46-49, 2008.

Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD; Infectious Diseases Society of America. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009 48:503-35, 2009.
Case Reports
1.
Sobel JD, Fanaroff A, Levin S: Cytomegalo-virus infection - report of 10 cases. S African Med J 43:1020-1025, 1969. Sobel JD, Schamroth L: Ulcerative colitis in South African Bantu. Gut 2:760-763, 1970. Kavin H, Sobel JD, Dembo K: Pancreatic ascites - treatment by irradiation of pancreas. Br Med J 2:503-504, 1971. Cohen Y, Brook G, Sobel JD, Auslander L. 85St uptake in lung metastases of osteogenic Jack D. Sobel, M.D.
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Sobel JD, Talor Z, Alroy G, Lichtig C, Valero A: Sjogren's syndrome, SLE, and glomerular nephritis. Postgrad Med J 53:97-101, 1977. Sobel JD, Rubin A, Valero A: Post-partum hemolytic uraemic syndrome. S African Med J 50:1860-1862, 1976. Sobel JD, Hampel N, Kurzbaum A, Adler O, Gellei B: Hypertension due to Ask-Upmark kidney. Br J Urol 49:477-480, 1977. Sobel JD, Carrizosa J, Gluckman S: Eikenella carrodens endocarditis. Am J Clin Sci 282:41-44, 1981. Raz V, Alroi G, Sobel JD: Nosocomial bacteremia due to Acinetobacter calcoaceticus. Infection 3:168-171, 1982. Sobel JD, Krieger R, Gilpin R, Agarwal P, Griska L: Legionella bozemanii - yet another cause of pneumonia. JAMA 250:383-385, 1983. Luboshitzky R, Sobel JD, Kurtzbaum A, Better OS, Spitz IM: Hypopituitarism with water intoxication and coma: favorable outcome following early treatment. J Endocrinol Invest 2:423-426, 1979. Yoffe N, Besser MI, Sobel JD, Front D: Early diagnosis of pyogenic sacroiliac infection using 67-gallium scintogram. Harefuah 104:55-56, 1983. Reinhart HH, Urbanski DM, Harrington SD, Sobel JD: Prosthetic valve endocarditis caused by Trichosporon beigelii. Am J Med, 84:355-358, 1988. Chua D, Reinhart HA, Sobel JD: Liver abscesses due to Streptococcus milleri. Rev Infect Dis 11(2):197-202, 1989. Vazquez J, Sobel JD: Disseminated cutaneous infection due to Mycobacterium marinum. Eur J Microbiol and Infect Dis 11:908-911, 1992. Sobel JD, Vazquez JA: Symptomatic vulvovaginitis due to resistant Candida albicans in a female who was not infected with Human Immunodeficiency Virus. Clin Infect Dis 22:726-727, 1996. Jack D. Sobel, M.D.
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Schuman P, Christenson C, Sobel JD: Idiopathic genital ulcers in women with AIDS. Am J Obstet Gynecol 174:1680-1683, 1996. Raz R, Rottem M, Bisharat N, Sakran W, Nussinson F, Trougauboff P, Sobel JD. Intestinal protothecosis in a patient with chronic mucocutaneous candidiasis. Clin Infect Dis 27:399-400, 1998. Sobel JD. Vaginal Mucormycosis. Infect Dis Ob/Gyn. 9:117-118, 2001. Kanno M, Sobel JD. Late recurrence of resistant trichomoniasis—relapse or reinfection? Sex. Trans. Inf. 79:260-261, 2003. Sobel JD, Funaro D, Kaplan EL. Recurrent Group A streptococcal vulvovaginitis in adult women: Family epidemiology. Clin Infect Dis 44:e43—45, 2007 Dan M, Sobel JD. Failure of nitazoanide to cure trichomonas in 3 women. Sex Trans Dis 813-4, 2007 Reichman O, Sobel J. Vulvar manifestations of Pellagra. Obstet Gynecol 2009 (in press) Reichman O, Sobel J. Mycoses fungoides presenting as vulvar fissure. J Lower Gen Tract Infect 2009 (in press)
Monographs
1.
Sobel JD: Genital herpes infection. Stuart Pharmaceuticals Monographs on Infectious Diseases, 1983. Sobel JD: Pathogenesis and treatment of vulvovaginal candidiasis. Stuart Pharmaceuticals Monographs on Infectious Diseases, 1983. Sobel JD: Repeated vaginal candidiasis: Relapse or reinfection. Miles Pharmaceuticals, 1987. Sobel JD and M Burnhill: Recurrent vulvovaginal candidiasis. Supported by Syntex Pharmaceuticals, 1989. Sobel JD: Vulvovaginal candidiasis, In: Diagnosis and Management of Serious Candida Infections, Candidiasis Roundtable. p 17, 1991. Sobel JD: Candidemia including catheter acquired candidemia. In: Diagnosis and Management of Serious Candida Infections. Candidiasis Roundtable p 20, 1991. Jack D. Sobel, M.D.
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Sobel JD: Vulvovaginal candidiasis. In: A contemporary approach to recognition and management, Wayne State University Continuing Medical Education Publication, 1997. Haefner H, Eschenbach D, Sobel JD. Vulvovaginal infections - ACOG Update, Audiocassette and text, 1998. Sobel JD. Perspectives on Amphotericin B formulation. Minimizing nephrotoxicity. Opportunistic fungi in the immunocompromised patient-mycology initiative of Immunocompromised Host Society (ICHS). (University of Pittsburgh) July 2001. Sobel JD. Emerging paradigm in the treatment of complicated UTIs. Clinical Courier Nov 30, 25:1-8, 2007.
Letters

1.
Sobel JD: Use of prophylactic antifungal agents in the ICU. Clinical consultant answer to clinical queries in J Critical Care, 7:325, 1992. Sobel JD: Surveillance cultures for fungi: Expensive and not the standard of care. J Critical Care 8:23-24, 1993. Sobel JD, Nagappan V, Nyirjesy P. Metronidazole-resistant vaginal trichomoniasis – an emerging problem. N Engl J Med 341(4):292-293, 1999. Klein R, Arnstein J, Sobel JD. Oropharyngeal Candida colonization and Human Immunodeficiency Virus Type-1 infection. J Infect Dis 181:812, 2000. Graybill JR, Sobel JD, The role of lumbar puncture in the management of elevated intracranial pressure in patients with AIDS-associated cryptococcal meningitis. Clin Infect Dis 33: 1310-11, 2000 Kullberg BJ, Sobel JD. Voriconazole in the treatment of candidemia. Lancet 2006
Articles Online-Electronic Print Only
1. Sobel JD. Urinary Tract Infections: Uncomplicated, complicated and nosocomial. Best Practice
of Medicine, http://praxis.md. New York: Praxi Press, May 2001. 2. Sobel JD. Prostatitis. Best Practice of Medicine, http://praxis.md. New York: Praxis Press, Jack D. Sobel, M.D.
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3. Sobel JD. Approach to the patient with vulvovaginal symptoms. (Updated annually) UpToDate 2002, 2003, 2004, 2005, 2006, 2007
4. Sobel JD. Vulvovaginal candidiasis. (Updated annually) UpToDate 2002, 2003, 2004,
2005, 2006, 2007, 2008

5. Sobel JD. Bacterial vaginosis. (Updated annually) UpToDate
2002, 2003, 2004, 2005,
2006, 2007, 2008

6. Sobel JD. Trichomoniasis. (Updated annually) UpToDate
2002, 2003, 2004, 2005, 2006,
2007, 2008

Editorials
1. Rex JH, Sobel JD. Preventing intra-abdominal candidiasis in surgical patients. Critical Care 2. Sobel JD. Mass or syndromic treatment of sexually transmitted diseases. Curr Infect Dis Rpts 3. Sobel JD: Failure of Metronidazole to prevent preterm delivery in women with asymptomatic bacterial vaginosis. Curr Infect Dis Rpts 2: 499-500, 2000 4. Sobel JD, Rex JH: Invasive candidiasis: Turning risk into a practical prevention policy? Clin 5. Sobel JD. Alternative treatment modalities for prevention of urinary tract infection in women: Lactobacilli or cranberry juice. Curr Infect Dis Rpts 3:527-8, 2001. 6. Sobel JD. Controversies in the diagnosis of candiduria—what is the critical colony count? Curr. Treatment Options in I.D. 4: 81-83, 2002. 7. Sobel JD. Management of uncomplicated Candida vaginitis: Evidence based. Ob/Gyn 4:158- 8. Sobel JD. Steroid therapy of vulvovaginal lichen planus. Curr. Rep. in Infect. Dis. 100:359- 9. Sobel JD. Estrogen therapy to prevent recurrent UTI in post-menopausal women. Curr Infect Jack D. Sobel, M.D.
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10. Sobel JD. The good and bad of Lactobacillus. Infect in Med 21:80-81, 2004. 11. Sobel JD. Intravaginal metronidazole versus metronidazole plus nystatin ovules for bacterial vaginosis. Evidence-based. Obstet & Gynecol 7:135-136, 2005. 12. Sobel JD. Does lactobacillus prevent post-antibiotic vulvovaginal candidiasis. Clinical Trial Report. Current Reports in Infect DIs 7:443-11, 2005 13. Sobel JD. Antifungal bladder irrigation when and not how to treat candiduria? Infect Dis Clin 14. Sobel JD, Revankar S. Echinocandins—First choice- First line therapy for invasive candidiasis. 15. Sobel JD. Changing epidemiology of invasive candidiasis in ICU’s—Much ado about
nothing. Critical Care Med 36:2188-9, 2008

16. Sobel JD. Duration of antibiotics treatment for urinary tract infections. Curr Infect Dis
Rep 10:483-4, 2008
Books Authored/Edited
1. Critical Care Clinics of North America. JD Sobel (Editor), W.B. Saunders, Philadelphia, PA, 2. Terconazole. JD Sobel (Editor), McGraw-Hill Book Company, New York, NY, 1990. 3. Vulvovaginal infections: Current Concepts in Diagnosis and Therapy. J.D. Sobel (Editor), Academy Professional Information Services, Inc., New York, NY, 1990. 4. Ketoconazole in Perspective: A Review of 10 Years' Experience in the Treatment of Fungal Infections. RJ Hay (Editor-in-Chief), DL Greer, PH Jacobs, JD Sobel, M Viviani (Guest Editors), Adis International Ltd., Chester, 1991. 5. Infections in I.V. Drug Abusers. DP Levine and JD Sobel (Editors), Oxford University Press, 6. The Principles and Practice of Medical Intensive Care, JD Sobel (Section Editor), RW Carlson, MA Geheb (Editors), WB Saunders Co., Philadelphia, PA, 1993. Jack D. Sobel, M.D.
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7. Dismukes W, Pappas P, Sobel JD, Ed. Clinical Mycology, Oxford Press, 2003 8. Sobel JD, Vazquez JA. Contemporary Diagnosis And Management of Fungal Infection. Handbooks in Healthcare Co, 1st Edition, Newtown, PA, 2003 9. Sobel JD. Section Editor. “Fungal Infections” in, “Antimicrobial Therapy Guide 18th Edition”, Antimicrobial Prescribing Inc, Newtown, PA, 2006. 10. Sobel JD, Vazquez JA. Contemporary diagnosis and management of fungal infection. Handbooks in Healthcare Co, 2nd Edition, Newtown, PA, 2006. 11. Sobel JD. Section Editor. Fungal infections in antimicrobial resistance. Mayer D, Lerner S,
Book Chapters
1.
Sobel JD: Infections of the oral cavity. In: Internal Medicine for Dentistry, LF Rose and D Kaye (Editors), Mosby, St. Louis, pp 298-308, 1983. Sobel JD and D Kaye: Urinary tract infections. In: Infectious Diseases, G Mandell, J Bennett, and G Douglas (Editors), 2nd Edition, 1984. Sobel JD: Pulmonary unfections in the immunocompromised host. In: The Pneumonias, ME Levison (Editor), John Wright, Boston, 1984. Sobel JD: Vulvovaginal candidiasis: Sexually related infectious diseases. In: Clinical Laboratory Aspects, T. Sun (Editor) Field Rich and Assoc., New York, NY, pp 143-153, 1986. Sobel JD: Comparison of Ketoconazole prophylactic regimens for treatment of recurrent vulvovaginal candidosis. In: Iwata K., Vanden Bossche H. eds. In vitro and in vivo evaluation of antifungal agents. Amsterdam:Elsevier Science Publishers. pp 241-6, 1986. Sobel JD and D Kaye: Host defense mechanism in urinary tract infections. In: Diseases of the Kidney, Schrier and Gottschalk (Editors), Little and Brown pp 967-993, 1987, 2nd Edition 1992. Sobel JD and D Kaye: Urinary tract infections. In: Textbook of Urology, J Gillenwater (Editor), 1st Edition, pp 246-303, 1987, 2nd Edition 1993. Sobel JD: Host Factors in the pathogenesis of urinary tract infections. V. Andriole (Editor), Jack D. Sobel, M.D.
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In: Infectious Disease Clinics of North America. Vol. 1(4) pp 751-772, 1987. Sobel JD: Candida infections in the intensive care unit. In: Critical Care Clinics of North America. W.B. Saunders Company, Philadelphia, PA, Vol 4, No 2, pp 325-344, 1988. Sobel JD and D Kaye: Urinary tract infections. In: Principles and Practice of Infectious Diseases, G Mandell, J Bennett and G Douglas (Editors) 3rd Edition 1989. Sobel JD: Evaluation of new antifungal drugs in treatment of Candida Vaginitis. In: Terconazole, McGraw-Hill Book Company, New York, NY, JD Sobel (Editor), pp 9-18, 1989 Sobel JD: Vulvovaginal candidiasis. In: Sexually Transmitted Diseases. 2nd Edition Holmes, Mardh, Sparling, Wiesner, et al (Editors), McGraw Hill, Chpt 45, pp 515-523, 1990. Sobel JD: Candida vulvovaginitis. In: Vulvovaginal infections: Current concepts in Diagnosis and Therapy. JD Sobel (Editor), Academy Professional Information Services, Inc., New York, NY, pp 36-56, 1990. Cook RL, Redondo-Lopez V, Sobel JD: The vaginal microflora of normal women. In: Vulvovaginal Infections: Current Concepts in Diagnosis and Therapy. JD Sobel (Editor), Academy Professional Information Services, Inc., New York, NY, pp 2-24, 1990. Sobel JD: Pathogenesis of Candida Vulvovaginitis. In: Current Topics in Medical Mycology. MR McGinnis (Editor), Springer-Verlag, New York, NY, Vol 3, p 86-108, Sobel JD: Imipenem and Aztreonam. In: Infectious Diseases Clinics of North America. D Kaye (Editor), W.B. Saunders Co., Philadelphia, PA, 2nd Edition, 1990. Sobel JD: Fungal infections of the urinary tract. In: Principles and Practice of Nephrology. 1st Edition, HR Jacobson, GE Striker, S Klahr (Editors), B.C. Decker, Inc, Philadelphia, PA, pp 612-618, 1990. Sobel JD: Therapeutic considerations in fungal vaginitis. In: Antifungals, Handbook of Experimental Pharmacology. JF Ryley (Editor), Springer-Verlag Publishers, Germany, pp 365-383, 1990. Sobel JD: Vaginal infections in adult women. In: Medical Clinics of North America, Jack D. Sobel, M.D.
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Sexually Transmitted Diseases, Vol 74, No. 6, p 1573-1602, 1990. Sobel JD: Controversial aspects of candidiasis in the Acquired Immunodeficiency Syndrome. In: Mycoses in AIDS Patients. H. Vanden Bossche, Donald MacKenzie, Geert Cauwenbergh (Editors),Plenum Press, New York, NY, p 93-100, 1990. Sobel JD, Kaye D: Urinary tract infections. In: Adult and Pediatric Urology. T Gillenwater (Editor), Mosby Co, St. Louis, MO, 2nd Edition, pp 275-339, 1990. Sobel JD: Vaginitis in adult women. In: Obstet-Gynecol Clinics of North America M Rosen, R Reid (Editors), W.B. Saunders Co, Philadelphia, PA, pp 851-879, 1990. Sobel JD: Candida vulvovaginitis. In: Sexually Related Infectious Diseases, T. Sun (Editor), Yearbook Medical Publishers, Inc., Chicago, IL pp 143-152, 1990. Sobel JD, Cook RL, and Redondo-Lopez V: Lactobacilli: A role in controlling the vaginal microflora. In: Vaginitis and Vaginosis. BJ Horowitz (Editor), Wiley-Liss Inc., New York, NY, pp 47-43, 1991. Sobel JD: Bacterial etiologic agents in the Pathogenesis of Urinary Tract Infection. In: Urinary Tract Infections, Medical Clinics of North America, D Kaye (Editor), Vol 75, pp 253-275, 1991. Sobel JD: Acquired Immunodeficiency Syndrome in Intravenous Drug Abusers. In: Infections in Drug Abusers. DP Levine and JD Sobel (Editors), Oxford University Press, New York, NY, pp 342-379, 1991. Sobel JD and H Reinhart: Antibacterial Host Factors in the Urinary Tract. In: Advances in Internal Medicine. GH Stollerman, JT LaMont, JJ Leonard, MD Siperstein (Editors), Mosby Year Book, Chicago, IL, Vol 36, pp 131-150, 1991. Brown P, and JD Sobel: Treatment of urinary tract infections in women. In: Conn's Current Therapy, RE Rakel (Editor), pp 600-604, 1992. Sobel JD: Vulvovaginitis. In: Dermatology Clinics of North America. M. Turner (Editor), W.B. Saunders Co, Philadelphia, PA, Vol 10, pp 339-359, 1992. Sobel JD: Genital candidiasis. In: Candidiasis: Pathogenesis, Diagnosis and Treatment, G. Bodey (Editor), 2, Edition, Raven Press, New York, NY, Chapter 12, pp 225-247, 1992. Jack D. Sobel, M.D.
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Bodey EP, Sobel JD: Lower gastrointestinal candidiasis. In: Candidiasis: Pathogenesis, Diagnosis and Treatment. GP Bodey (Editor), Raven Press, New York, NY, 2nd Edition, Chapter 11, pp 205-224, 1992. Sobel JD. Nosocomial endocarditis. In: Infective Endocarditis, D. Kaye (Editor), Raven Press, New York, NY, 2nd Edition, pp 361-373, 1992. Sobel JD: Candida infections. In: The Principles and Practice of Medical Intensive Care, RW Carlson, MA Geheb (Editors), WB Saunders Co., Philadelphia, PA, Chapter 33, pp 434-444, 1993. Sobel JD, H Reinhart, and D Kaye: Host defense mechanisms in urinary tract infections. In: Diseases of the Kidney. R. Schrier, Gottschalk (Editors), Little, Brown and Company, Boston, MA, (Fifth Edition), pp 885-908, 1993. Sobel JD: Rare causes of vaginitis. In: Vulvovaginitis, P Elsner, J Martius (Editors), Marcel Dekker Inc., New York, NY, Chapter 18, pp 403-416, 1993. Sobel JD: Vulvovaginal candidiasis. In: Infections in Obstetrics and Gynecologic Disease, JG Pastorek (Editor), Aspen Books, Rockville, MD, pp 523-536, 1994. Sobel JD: Vulvovaginitis. In: Infectious Diseases, 5th Edition, Hoeprich PD, Jordan MC, Ronald AR (Editors), JB Lippincott Co, Philadelphia, PA, Chapter 60, pp 575-582, 1994. Sobel JD, Vazquez J: Fungal infections of the gastrointestinal tract. In: Gastrointestinal and Hepatic Infections, CM Surawicz and RL Owen (Editors), W. B. Saunders Company, Philadelphia, PA, pp 219-245, 1994. Sobel JD, Kaye D. Urinary tract infections. In: Principle and Practice of Infectious Diseases, Mandell G, Bennett J, Dolin R (Editors), 4th Edition Chapter 55, pp 662-690, 1994. Levine DP, Sobel JD. Infections in IV drug abusers. In: Principles and Practice of Infectious Diseases, Mandell GL, Bennett JE, Dolin R,(Editors), Churchill Livingstone Publishers, New York, NY Chapter 290, pp 2696-2709, 1994. Sobel JD: Management of Vaginosis: prevention and treatment. In: The Treatment of protozoal infections: Role of single dose secnidazole. Adis International Med Publish Drug Investigation 8(Suppl 1):26-34, 1994. Jack D. Sobel, M.D.
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Sobel JD: Fungal infections of the urinary tract. In: Principles and Practice of Nephrology, Jacobson HR, Striker GE, Klahr S (Editors), 2nd Edition, B.C. Decker Inc., Philadelphia, PA pp 497-503, 1995. Vazquez J, Sobel JD: Fungal infections in diabetics. In: Infectious Disease Clinics of North America, Eliopoulos GW (Editor), WB Saunders Co, Philadelphia, PA 9(1):97-116, 1995. Sobel JD: Fungal diseases in genitourinary medicine. In: Principles and Practice of Clinical Mycology, Kibbler CC, Mackenzie DWR, Odds FC (Editors), John Wiley & Sons Ltd, London, pp 179-199, 1995. Fidel P, Sobel JD: Immunopathogenesis of recurrent vulvovaginal candidiasis. In: Cliniguide to Fungal Infections, 6:1-8, 1995. Lundstrom T, Sobel JD: Vancomycin, trimethoprim-sulfamethoxazole and rifampin. In: Infectious Disease Clinics of North America, Kaye, D (Editor), WB Saunders Co, Philadelphia, PA Vol 9, pp 747-767, 1995 Sobel JD, Vazquez JA: Urinary tract infections due to Candida species. In: Molecular Pathogenesis of Urinary Tract Infections, Mobley H. and Warren JW (Editors), American Society for Microbiology, Washington, DC pp 119-131, 1995. Sobel JD: Vulvovaginal candidiasis. In: Sexually-related Infectious Diseases: Laboratory Aspects, 3rd Edition, Tsieh Sun (Editor), Field & Wood, Inc., Philadelphia, PA, 1995. Sobel JD: Candiduria. In: Current therapy of Infectious Diseases, Schlossberg D (Editor), Mosby Year Book, Philadelphia, PA pp 193-194, 1996. Sobel JD: Candida vulvovaginitis. In: Seminars in Dermatology, The Vulva in Health and Disease, Elsner P, Pincus SH (Editors), WB Saunders Co, Philadelphia, PA 15:17-28, 1996. Sobel JD: Vulvovaginal candidiasis. In: Atlas of Infectious Diseases, Mandell, G (Editor), Current Medicine, Philadelphia, PA Vol 5, Chapter 7, sections 7.2-7.7, 1996. Sobel JD: Urinary tract infections: uncomplicated, complicated and nosocomial. In: Current Practice of Medicine, Bone R, Neu H (Editors), Current Medicine, Philadelphia, PA, Vol 2, Chapter 9, 1996. Gallis H, Sobel JD. Candiduria. In: Urinary Tract Infections and Infections of the Female Pelvis, Atlas of Infectious Diseases. G. Mandell (editor), Vol 9, Chapter 5, 5.2-5.15, 1996. Jack D. Sobel, M.D.
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Lundstrom TS, Sobel JD: Fungal infections. In: Association for Professionals, Infect Cont Epid Curr, R Olmstead (Editor), Mosby Year Book Publishers, Chicago, IL, Chapter 28, pp. 591-8, 1996. Sobel JD: Pathogenesis of urinary tract infections. Role of host defenses. In: Infectious Diseases Clinics of North America, V. Andriole (Editor), 11:531-551, 1997. Sobel JD: Vaginitis. In: Emergency Care of the Women, M.D. Pearlman, Judith E. Tintinalli (Editors), McGraw-Hill Publishers, Chapter 43, pp 535-549, 1998. Sobel JD. Vulvovaginal candidiasis. In: Sexually Transmitted Diseases. Holmes KK, Mardh P-A, Sparling PF, Lemon SM, Stamm WE, Piot P, Wasserheit JN (Editors), MaGraw Hill, New York, Chapter 45, p 629-639, 1998. Rex J, Sobel JD, Powderly W. Candida Infections. In: Antimicrobial Therapy and Vaccines, Yu VL, Merigan TC Jr, Barrier SL (Editors), William & Wilkins, Baltimore, Maryland, 1st edition, pp1054-1076, 1998. Sobel JD. Biotherapeutic agents as therapy for vaginitis. In: Probiotic Therapy, GW Elmer, LV McFarland, CM Surawicz (Editors), Humana Press, Inc, Totowa, NJ, 221-244, 1999. Sobel JD: Urinary Tract Infections: Uncomplicated, complicated, and nosocomial. In: Current Practice of Medicine. FT Fitzgerald (Editor), Vol 2, Number 4, 164:555-562, 1999. Sobel JD, Vazquez J: Fungal infections of the urinary tract. In: Comprehensive Clinical Nephrology, RJ Johnson, J Feehally (Editors), Mosby International, Chapter 58, Section 10, pp 58.1-58.6, 1999. Fidel PL Jr, Sobel JD. Murine models of Candida vaginal infection. In: Handbook of animal models of infection. Zak O, Sande M (Editors), Academic Press, Guersney UK, Chapter 90, pp 741-748, 1999. Sobel JD, Kaye D. Urinary Tract Infections. In: Principles and Practice of Infectious Diseases, Mandell G, Bennett J, Dolin R (Editors), Churchill Livingston, Philadelphia, PA, 5th Edition, Vol 1, Chapter 62, pp 773-805, 2000 Sobel JD: Candiduria. In: Current Therapy of Infectious Diseases, Schlossberg D (Editor), Mosby Year Book, Philadelphia, PA., p 233-236, 2nd edition, 2000. Sobel JD. Mucocutaneous candidiasis. In: Fungal Infections, R Diamond (Editor), Atlas of Jack D. Sobel, M.D.
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Infectious Diseases. Churchill Livingston, Chapter 8; 118-136, 2000. Sobel JD: Vulvitis, vaginitis and cervicitis. In: Infectious Disease, D Armstrong, Cohen J (Editors), Mosby, London, United Kingdom, Chapter 52, pp 1-8, 2000 Lundstrom TS, Sobel JD. Vancomycin, Teicoplanin, Quinupristin/Dalfopristin and Linezolid. In: Infectious Disease Clinics of North America, D. Kaye (Editor). 14:463-474, 2000. Lundstrom TS, Sobel JD. Fungal Infections: Candida and other pathogenic fungi. In: APIC Infection Control and Applied Epidemiology: Principles and Practice, R. Olmstead (Editor), Mosby Year Book, Inc., St. Louis, Missouri, Chapter 29, 2000. Sobel JD: Genital candidosis. In: Medicine, Sexually Transmitted Infection Medicine Publishing Co, Oxford, UK, Vol 29: 8:67-71, 2001. Sobel JD: Candida vaginitis. In: Infectious Diseases in Obstetrics and Gynecology, S Faro, D Soper (Editors), WB Saunders, 1st edition p39-54, 2001. Fidel PJ Jr, Sobel JD: Host defense against vaginal candidiasis. In: Candida and Candidiasis. Calderone RA (Editor) pp 193-209, 2001. Sobel JD: Urinary tract infections and infections of the female pelvis In: Essential Atlas of Infectious Diseases 2nd edition. Editor Mandell G. Churchill Livingston, 2nd Edition, pp. 268-290, 2001. Sobel JD: Vaginitis and Cervicitis. In: Expert Guide to Infectious Diseases, J Tan (Editor) American College of Physicians, 1st Edition, Philadelphia, PA, pp 316-340, 2002. \ Sobel JD. Recent advances in the treatment of vulvovaginal candidiasis. In: Contemporary Therapy in Obstetrics and Gynecology. Ransom S, Dombrowski M, Evans M and Ginsburg K (Editors) pp 405-409, 2002. Sobel JD: Fungal infections of the genitourinary tract. In: Clinical Mycology, E Anaissie, M McGinnis, M. Pfaller (Editors), WB Saunders, p 496-508, 2002. Brown PD, Sobel JD. Bacterial infections of the urinary tract in women. In: Conn’s Current Therapy. Rakel R (Editor), Elsevier Science, Philadelphia p 736-739, 2003. Hillier S, Sobel JD. Vaginal Infections. In: Atlas of Sexually Transmitted Diseases and Jack D. Sobel, M.D.
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AIDS, 3rd Edition. Morse S, Holmes KE, Editors. Harcourt Health Sciences, U.K., p 159-176, 2003. Sobel JD. Vaginitis, vulvitis and cervicitis and cutaneous vulval disease. In: Infectious Diseases, Cohen J, Powderley WG (Editors), 2nd Edition, Harcourt Publications, London, UK., p 683-692, 2003. Sobel JD, Vazquez J. Fungal infections of the urinary tract. In: Comprehensive Clinical Nephrology, Johnson RJ, Feehally E (Editors), 2nd Edition, Mosby International, p 715-722. 2003. Sobel JD, Vazquez J. Candidiasis. In: Clinical Mycology. Dismukes W, Pappas P, Sobel JD (Editors),Chapter 11, Oxford Press, UK, pp 143-187, 2003. Sobel JD. Vaginitis. In: Obstetric and Gynecologic Emergencies. Pearlman MD, Tintinelli J, Dyne P (Editors) McGraw-Hill, New York, p 449-464, 2004. Sobel JD. Infections of the urinary tract and female pelvis. In: Essential Atlas of Infectious Diseases”, Third Edition, Mandell G (Editor) Churchill Livingston p 252-270, 2004. Sobel JD, Kaye D. Urinary tract infections. In: Principles and Practices of Infectious Diseases. Mondell G, Bennett J, Dolan R (Editors), 6th Edition, Churchill Livingston, Philadelphia, PA 2004 Lundstrom, TS, Sobel JD. Fungal Infections: Candida and other pathogenic fungi. In: APIC Infection Control and Applied Epidemiology: Principles and Practice: R. Olmstead (Editor), Chapter 92, Mosby Year Book, Inc, St. Louis, Missouri, 2004, p 92-13. Sobel JD. Genital candidiasis. In: Medicine. Section: Sexually Transmitted Infection. Medicine Publishing Co, Oxford, UK, pp 62-65, 2005. Rex J, Sobel JD, Powderly W. Treatment of candidiasis in HIV-infected persons. In: Antimicrobial Therapy in AIDS. Yu VL, Merigan T, Barrier SL (Editors), Williams, Wilkins Publishers, Baltimore, 2005

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