La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.

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June 6th, 2011 11
Industrial Restructuring Catalog (2011 Edition)
for Petroleum, Chemical and Related Sectors ( II )
and an elas ticity modulus of 240GP a and using t he acet one cy anohy drin p rocess , above, aramid fiber (A F ), p olys ulfone grain-based acetone/butanol units , prop y- amide (PSA), ult ra-high molecular w eight l e n e o x i d e u n i t s u s i n g t h e (Continued page 6, is sue 10, 2011) poly et hy lene (U HM WPE) fiber (sp inning chlorohy drinat ion proces s and ep ichloro- units w it h a single line production cap ac- hy d rin un it us i ng t he s ap on ificat ion Te xtil es
ity of 300 t/a and above), poly phenylene p roces s, and sap onin (cont aining hydro- s ulfide (P PS) fiber, p oly imide (PI) fiber, lyt ic matt ers ) units (excluding unit s for poly tetrafluoroethene (PT FE) fiber, P BO comprehensive ut iliz at ion) with a cap ac- modification of differential and functional (p olybenzoxazole) fiber, p olyoxadiaz oles polyes ter (P ET) (cationic-dyes tuff dyeable (P OD ) fiber, basalt fiber (BF ), s ilicon car- 3. N ewly cons truct ed poly p rop ylene poly est er (CDP and ECDP ), alkali-soluble bide fiber (SiCF ) and high s trength fiber- (PP ) unit s (us ing the cont inuous proces s poly es ter (CO PET), high-shrinkage p oly- or t he int ermit tent p rocess ) w it h a capac- es ter (H SP ET ), flame ret ardant p olyest er it y of below 70 000 t /a, p oly ethylene (P E) and low melt ing p oint poly est er, etc.); t he unit s with a capacit y of less t han 200 000 p roduction of different ial and funct ional t/a, p olyvinyl chloride (P VC) unit s us ing fibers (ant ist at ic fibers , ultraviolet res is - t he calcium carbide proces s , P VC unit s tant fibers and colored fibers ) by the con- us ing t he ethylene oxychlorination process tinuous proces ses; t he p roduct ion of dif- Pe tr oc he mic al s ec tors
with an init ial capacity of below 300 000 ferent ial and funct ional p oly es t er (P ET ) t /a, poly st yrene (P S) unit s with a cap ac- as w ell as fibers wit h int elligence and 1. N ew ly const ruct ed atmos pheric and it y of les s than 100 000 t/a, acry lonitrile- s up er emulat ion; and t he p roduction of vacuum dist illat ion units w it h a cap acit y butadiene-s tyrene cop olymer (A BS) units differential and funct ional modified fibers of les s t han 10.0 million t /a, cat aly t ic (excluding units us ing t he bulk cont inu- cracking unit s with a capacity of les s than ous process) w ith a capacit y of below 200 acrylic fibers , poly amide fibers , sp andex 1.5 million t /a, continuous reforming units 000 t/a, and general sy nthet ic lat ex-car- (including aromat ic hy drocarbon ext rac- b oxy l a t e d s t y r en e -b ut a di e ne l a t e x t ion unit s ) w it h a cap acity of below 1.0 (including st yrene-butadiene latex) unit s cat ion of new-ty p e poly est er and fibers , million t/a, and hy drocracking units w it h w it h a cap acit y of below 30 000 t /a, and s uch as p oly trimet hy lene t erep hthalat e a cap acit y of les s t han 1.5 million t/a (P TT ), p olyethylene naphthalene (P EN ), 2. New ly const ructed ethylene units us- general-p urpose adhes ives including s ol- p o ly but y l ene t ere p h t h ala t e (P BT ), ing nap htha cracking p roces s wit h a ca- vent-bas ed chlorop rene rubber adhesive, p o ly b ut y len es s uc ci nat e ( P BS ) a nd p acit y of below 800 000 t /a, acry lonitrile s ty rene-but adiene t hermoplast ic rubber poly cyclolexylene dimethylene t erephtha- unit s with a capacity of less than 130 000 adhes ives, p olyuret hane adhes ives and t/a, P TA (purified t erephthalic acid) units 3. Production of new fibers (solvent-pro- w it h a capacit y of below 1.0 million t /a, 4. N ewly cons t ruct ed s oda as h units , cess cellulos e fiber (Ly ocell), bact erial cel- M EG (mono-ethylene gly col) unit s with a caus tic s oda unit s , s ulfur-based s ulfuric lulos e fiber, regenerative cellulos e fiber capacity of less t han 200 000 t/a, s ty rene acid unit s w ith a cap acity of below 300 made from new-t ype regenerative res ources units (excluding unit s us ing dry gas t o 000 t/a, p yrite-bas ed s ulfuric acid unit s like bamboo and hemp , p oly lact ic acid produce ethyl benz ene) with a capacit y of w it h a cap acit y of les s than 200 000 t /a, (PLA ) fiber, alginat e fiber, chitin fiber, below 200 000 t /a, cap rolact am unit s with nitric acid unit s us ing the atmos p heric poly hy droxyalkanoates (P HA ) fiber, and a capacity of less t han 100 000 t/a, acetic p ress ure p roces s and t he comprehens ive animal and veget able protein fiber) by en- acid units us ing the ethylene process , ace- p rocess , calcium carbide unit s (excluding vironmental friendly processes and equip- tic acid unit s us ing t he carbonylat ion pro- unit s us ing large-scale advanced p rocess es cess w it h a cap acity of below 300 000 t/a, nat ural gas -t o-met hanol unit s , coal-t o- and p ot as s ium hy droxide unit s w it h a ganic and inorganic high-p erformance fi- met hanol unit s (excluding units for com- s ingle-line capacity of below 50 000 t/a bers and products (carbon fiber (CF ) with prehensive utilization) with a cap acit y of 5. Newly const ruct ed s odium t ripoly - a tens ile st rengt h of 4 200M Pa and above less t han 1.0 million t/a, acrylic acid units June 6th, 2011 11
hexamet ap hos phat e units , p hos phorus chlorp y rfos unit s (excluding unit s us ing accelerator T M TD (t et ramet hy l t hiuram trichloride unit s, phos phorus p entasulfide the water-phase process ), t riazophos unit s, units , feed-grade calcium hydrogen phos - p ara quat u nit s , chloro t halon il uni t s , phat e units, sodium chlorat e unit s, sodium avermect in units , imidaclop rid unit s and Pharmac euti c al s ec tor
dichromat e unit s us ing t he les s calcium acet ochlor unit s (excluding units using t he roast ing process , electroly tic manganes e dioxide units , general calcium carbonat e gulonic acid units and vitamin C (including unit s , anhy drous sodium s ulfate unit s ide unit s using the s ulfuric acid process , (excluding t he co-p roducts and byproducts lead chrome y ellow units , iron oxide p ig- cosmet ic-grade vitamin C) units, and new ly of t he s alt indus t ry ), barium carbonat e ment units wit h a cap acit y of below 10 cons t ructed units for the p roduction of units , barium sulfat e unit s, barium hy drox- 000 t/a, s olvent-based coat ings (excluding ide unit s, barium chloride units, barium ni- t he encouraged variet ies and p roduct ion cosmetic-grade vitamin B1, vitamin B1, vi- trate units , s trontium carbonat e unit s, sili- p ro c es s es of co at i ngs ) u ni t s , an d tamin B12 (excluding vitamin B12 for com- con dioxide (excluding gas p hase silicon t riglycidyl isocy anurat e (T GIC)-contain- prehensive ut ilization) and vitamin E.
dioxide) units , choline chloride unit s, p o- 2. Newly constructed units for the produc- t as s ium p ermanganat e unit s us ing t he 11. N ewly built dy es , dye intermediat e, tion of penicillin industrial s alt, 6-A PA (6- open-heart h proces s, and sodium sulfide aminopenicillanic acid), chemical-met hod- units using the caldron evaporation p rocess t ive p roduction unit s (excluding t he en- based 7-ACA (7-aminocephalosporanic acid), 7-ADCA (7-aminodesacetoxy cephalosporanic units with an init ial production capacity of acid), Penicillin V, ampicillin, amoxicillin, les s t han 30 000 t /a, s odium cy anide 12. N ew ly built hydrogen fluoride (H F) cepalosporin C, oxytetracycline, tetracycline, (containing 100% NaCN ) units with single- units (excluding unit s for the product ion chloramp henicol, analgin, p aracet amol, line capacity of below 10 000 t /a, lit hium of electronic grade hy drogen fluoride and lincomycin, gentamicin, dihydrostreptomycin, carbonat e units w ith a capacity of less t han t hose as the s up port ing facilit ies of w et - am ika cin, me dem y ci n, kit a s am y ci n, 5 000 t/a, lit hium hydroxide units w it h a p ro ce s s p h os p ho ri c a ci d) , m et hy l cip rofl oxacin, norf loxacin, ofl oxacin, cap acit y of below 5 000 t/a, and anhydrous chloros ilane monomer units wit h an ini- rifampicin, caffeine and theobromine.
aluminum fluoride units or cryolite (with tial cap acity of below 200 000 t/a, methyl low and medium mole ratio) units w it h a chloros ilane monomer unit s with a s ingle Lig ht i ndus tr y
line cap acit y of les s t han 100 000 t /a, 7. N ewly cons tructed nitrogen fertiliz er methane chloride unit s (excluding t he sup- 1. Convent ional PVC leat her production unit s using pet roleum (excluding high-sul- port ing units of s ilicone plants) w ith a ca- fur p etroleum coke) and nat ural gas as raw pacity of below 100 000 t /a, and met hane 2. Super-t hin (less than 0.015mm t hick) materials, synthet ic ammonia unit s using the chloride unit s w ith a capacity of more than fi xe d be d int er mi t t en t ga s i fi ca t i on 100 000 t/a but without facilit ies for dis- technology, ammonium phosp hate units , and p osing by p roduct carbon t etrachloride; plast ic p roduct ion lines and continuous ex- copper-washing purification process for raw n ew ly - bu il t a nd e xp a nd ed H C F C s truded polys tyrene (X PS) foam plast ic p ro- 8. N ew ly cons tructed unit s of pes ti- cides w it h high t oxicit y, high pers is tence thos e to produce HCF Cs as raw mat erials 4. P VC p ackage films for food pres er- omet hoat e, is ocarbop hos , is ofenp hos - p erfluorooct anesulp honat e (P FO S) unit s met hy l, p horat e, t erbufos, methidat hion, and perfluorooctanoic acid (PF OA ) unit s, Te xtil e ar eas
an d s ulf ur hexaflu ori de (SF 6) uni t s c a r bo f u r a n , s o d i u m d i p h a c i no n e , dip hacinone, w arfarin, coumat et raly l, 13. N ewly const ruct ed bias t ire units , tinuous p olymerization unit s w ith a s ingle- cycle tire (cart t ire) unit s , polyamide fi- toxin, bis ultap, ethoprop hos, endos ulfan, ber cord units , st eel cord units w it h a ca- 2. Conventional dimet hy l t erephthalate aluminum phos phide, dicofol, organochlo- p acit y of below 30 000 t /a, convent ional rine insect icides , organot in ins ect icides , reclaimed rubber unit s (excluding unit s 3. Semi-continuous s pun vis cos e fila- thiram fungicides and sodium (p otass ium) us ing t he dy namic cont inuous des ulfuriz a- t i o n p r o c e s s ) , r u b b e r p e p t i z e r 4. Intermit tent sp andex polymerization 9. Newly constructed gly phosate unit s, p entachlorothiop henol unit s, and rubber June 6th, 2011 11
8. the product ion of coat ings-p urpos ed 4. Sodium t rip olyp hos phate units w ith a res ins by the direct fire heating method, the s ingle-line capacit y of below 10 000 t /a, production of chlorinated rubber by the car- Note: The time marked in bracket s after an s odium hexametap hos phate units wit h a bon t etrachloride solvent method, Saponin item is the elimination deadline of the item.
capacity of les s t han 5 000 t/a, p hosp horus (containing hydrolytic matt ers) unit s wit h a For example, if the elimination deadline of trichloride units with a capacity of below 5 cap acit y of below 100 t /a, Saponin unit s an it em is 2011, it means t hat t he item 000 t /a, feed-grade calcium hydrogen phos- using the hy drochloric acid hydrolys is p ro- should be eliminated before the end of 2011.
phate units wit h a capacity of below 30 000 cess whose pollutant emis sions cannot reach It ems wit h eliminat ion deadlines should be t/a, hydrogen fluoride (H F) unit s using out- the national s tandards , and iron powder re- eliminated before the deadlines. Eliminat ed dated process es and technologies with s e- duction processes (those for the product ion items w it hout elimination deadlines have rious p ollut ion and a capacit y of less than of DSD acid (4,4-diaminodiphenylethylene- already been ordered by t he Chines e gov- 5 000 t /a, wet-proces s aluminum fluoride ernment to be eliminated immediately.
units w it h a cap acit y of below 5 000 t /a, chloro-4-methybenz enesulfouic acid) and H and open cryst alliz at ion villiaumit e units Eli minated pr oduc ti on units
NaCN) unit s w ith a single-line capacity of 9. Bias tire units with a capacity of 500 Petroch emical an d ch emi cal areas
les s than 3 000 t/a, p ot as s ium hy droxide 000 pieces/a and below, tire production lines unit s w it h a cap acity of below 10 000 t/a, that use the natural cotton cord as the rim and 1. A tmospheric and vacuum dist illation general silicon dioxide unit s wit h a capac- have a capacity of 500 000 pieces/a and below, units (excluding unit s in Golmud, Qinghai it y of les s t han 15 000 t/a, general calcium carbon black units (except for units for the province and in Zepu, Xinjiang region) with carbonat e units w ith a cap acity of below 20 production of special carbon black and semi- a cap acit y of below 2.0 million t/a (2013), 000 t/a, general anhydrous s odium s ulfate reinforced carbon black) t hat use t he dry oil refining units using scrap rubber and plas- unit s (excluding co-products and byproducts granulation process and have a capacity of 15 tic indigenous methods , and as phalt produc- of the salt indus try) with a cap acity of less 000 t/a and below, natural latex condom units tion units using the tar intermitt ent process t han 100 000 t /a, lit hium carbonat e unit s with a capacity of less than 300 million pieces/ 2. Pyrite-based s ulfuric acid and sulfur- with a capacit y of below 3 000 t /a, lithium a, rubber curing accelerator N-oxydiethylene- base sulfuric acid units (excluding unit s in hydroxide units w ith a capacity of less t han border and remote regions ) with a cap ac- 3 000 t /a, general barium carbonat e unit s ity of below 100 000 t/a, p ot as sium p er- wit h a capacit y of below 20 000 t/a and gen- 10. The follow ing p roduct s, p rocess es manganat e unit s using the op en-hearth oxi- eral strontium carbonate units w ith a cap ac- a n d u n i t s s h o u l d b e e l i m i n a t e d dation proces s, caus tic soda units using t he immediately: chlorofluorocarbons (CFCs ), diaphragm p rocess (2015), open-hearth and 6. Semi-water gas liquid-p has e desulfur- H CF C s , cl e an i ng- p u r p o s ed 1, 1 ,1 - caldron evap oration proces ses for alkali iz ation p rocess wit h ammonia liquor, nat u- trichloroet hanol (methyl chloroform), pro- sulfide p roduction, and mirabilit e process ral gas atmos pheric p res sure int ermitt ent duct ion unit s t hat mainly produce carbon convers ion p roces s for sy nthet ic ammonia tetrachloride (CTC), all p roducts t hat use 3. Yellow phosphorus units with a single production, carbon monoxide at mos pheric CT C as the p roces sing ass is tant, fluorine- cap acit y of below 5 000 t /a and y ellow pressure s hift and full medium-t emperature phos phorus unit s that can not conform to shift (high-temperature shift) process , wet- the threshold conditions, chrome compound process desulfurization process without sul- dichlorodipheny lt richloroethane (DD T)- production units using the calcium-contain- fur recovery unit s, and fixed bed intermit- containing p aints and coatings , and non- ing roas ting p rocess (2013), general barium tent coal gasification units w ithout blowing closed p roduct ion unit s of dicofol us ing sulfate, barium hy droxide, barium chloride gas waste heat recovery unit s and gas-mak- DD T as the raw material (t hes e product s, and barium nitrate unit s with a single-line ing s lag comprehensive utiliz ation units proces ses and p roduction unit s should be cap acity of less t han 3 000 t/a, sodium chlo- eliminated according to t he overall plan of rate units wit h a capacit y of below 10 000 duct ion proces s, t richlorfon-alkaline-pro- the Chinese government 's implementing in- t/a, calcium carbide kilns with a single ca- cess -based dichlorvos product ion p roces s, pacit y of below 12 500 kVA and op en cal- p roces ses and equip ment for t he manual cium carbide kilns , high mercury cataly st packing (filling) of s mall-packed (1 kg and Lig ht i ndus tr y
units (cont ent of mercuric chloride being below) pes ticide products , Ray mond-mill- bas ed p esticide pow der production p rocess, 1. Vacuum salt units w ith a capacit y of units us ing high mercury cat aly st, and am- p entachlorop henat e (sodium) unit s us ing below 100 000 t/a, lake salt production fa- June 6th, 2011 11
cilities w ith a capacity of less than 200 000 t/a, and sea salt production facilit ies with emuls ion ext erior wall coat ings , t ar-t yp e 5 . H i gh l y t o xi c p e s t i c i d e s : a capacit y of below 300 000 t/a in China's polyurethane waterproofing coatings, w ater- bas ed PVC tar-t ype waterproofing coatings, da min oz i de , b is - A D T A , ni t ho p he n, 2. Sea s alt production units w it h a ca- p olyvinyl alcohol and acet al int erior and pacity of 20 000 t/a and below in China's fluoroacet amide, s odium fluoroacet at e, coat ings), and p olyviny l acetate emulsion d i br o m o ch l o r op r o p an e , s u l f o t e p , 3. Super-t hin (less than 0.025mm t hick) (including EVA (et hy lene-viny l acetat e p ho s p ha m i do n , gl i ft o r , s i la t r an e , cop olymer) emulsion) ext erior wall coatings me t h am ido p h os , p ar at h io n, me t h y l 4. P roduct ion of P VC p ackaging p rod- 2. Excessive-harmful-subs tance-contain- p arat hion, monocrot op hos , p hos folan, ing coatings for int erior walls , solvent-based asomat e, urbacide, as w ell as all ars enic 5. Production of benz ene-containing sol- wood, toys, automotives and ext erior walls, p rep arations , mercury compounds , lead and coat ings t hat cont ain hazardous sub- p rep arat ions , 10% gly p hosat e aqueous 6. Production of p olyurethane, PE and PS s t anc es s uch a s dichlo rodip heny lt ri- s ol ut ion , p ho s fola n-me t hy l, calc ium foam plastics us ing CFCs as blowing agents chloroet hane, tributyltin, perfluorooctanoic p hosp hide, zinc phos phide, fenamiphos , aci d (P F O A ) as w ell as t heir s al t s , fonofos, magnes ium phosphide, cadus afos, perfluorooctanesulfonic acid, and red lead.
8. Production proces ses using t richloro- 6. P es ticides that should be eliminat ed trifluoroet hane (CFC-113) and methyl chlo- according t o the overall p lan of the Chi- roform (TCA) as cleaning agents and solvents reducing condition (az o dyes used in non- nes e government imp lement ing int erna- 9. F att y acid p roces s -bas ed t ert iary t e xt il e s e ct or s ar e p os t p oned t o be amine p roduct ion p roces s, fuming s ulfuric eliminat ed), and 9 carcinogenic dyes (those h ep t ac h l or , b r om o me t ha n e , D D T , acid s ulfonation proces s, and st irred tank us ed areas w ithout direct cont act w ith t he he xa ch lo ro ben z e ne , mi rex, li nd an e, h um an bo d y ar e p o s t p o n ed t o b e 7. Bicycle tires w ith a s oft-rim structure, Outdate d pr oduc ts
4. P aint removers that contain benzene, general convey ing belt s us ing t he cot ton p henol, benz aldehy de, dichloromet hane cord as the s keleton mat erial, general V 1. M odified starch coat ings , modified fi- belt s us ing t he ny lon cord as t he skelet on ber coatings , color interior w all coatings (O/ based cons t ruction, wat erp roofing and W coat ings mainly using nitrocellulos e as s eaming mat erials (t ar-t y pe), ty p e 107 niz ing moulds for t ires , bicycle tires and the res in and xylene as t he solvent), vinyl adhesive, clenbuterol and poly chlorinat ed

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