Many international bodies now regard access to pain relief as an essential human right.
One problem affecting as many as175 million people around the world, according to the
World Health Organization is arthritis, a chronic disease that affects any joint, primarily
For these patients, AstraZeneca has introduced a new prescription medicine, Vimovo®, to
relieve the signs and symptoms of arthritis while reducing the risk of ulcers.[i]
Arthritis is a general term for different types of joint diseases. Osteoarthritis (OA) is the
most common form, and it is caused by the breakdown of the cartilage that cushions the
ends of the bones, causing them to rub together and producing pain and stiffness (see
below “Three Types of Arthritis and Impacts of Joint Diseases.”)
Pain Relief with Built-in GI Protection
Some patients may develop several gastric events from heartburn to a bleeding ulcer.
Fulfilling the need for an effective pain relief medication with good GI tolerability the
combination of Naproxen/esomeprazole relieves the symptoms and signs of rheumatoid
arthritis (RA), osteoarthritis (OA) and ankylosing spondylitis (AS) in patients at risk of
Naproxen/esomeprazole is an analgesic product that releases its components sequentially.
For pain relieving the product offers a fixed-dose of enteric-coated naproxen, an effective
non-steroidal anti-inflammatory drug (NSAID). The tablet is coated with immediate-release
esomeprazole, required so as to provide ulcer-risk reduction before the pain treatment is
According to AstraZeneca’s medical director, Dr. Yessika Moreno, “This medication is an
advanced formulation. The enteric-coated formulation of naproxen ensures that
esomeprazole is released first in the stomach to play its ulcer-risk reduction role. By
delaying the release of naproxen, the product ensures ulcer-risk reduction is present with
Three Types of Arthritis Osteoarthritis (OA) Rheumatoid Arthritis (RA) Ankylosing Spondylitis (AS)
OA is the most common type of arthritis. It is
RA is a different type of arthritis that is caused
AS is an arthritis-related joint disease. The
caused by the breakdown of the cartilage that
not by daily use of the joints but by a glitch in
exact cause is unknown, but genetics is thought
cushions the ends of the bones, causing them to
the body’s immune system that causes it to
attack and break cartilage down and damage the
OA results in pain and stiffness, particularly in
RA results in pain primarily in the wrists,
AS results in pain primarily in the spine but can
hands, and feet; however, the neck, elbows,
affect other joints. Over time, AS breaks down
shoulders, knees, hips, and ankles can also be
bone and cartilage, causing the spine joints to
Impacts of Joint Diseases
According to the World Health Organization, the global estimated prevalence of Osteoarthritis is over 151 million
people, while Rheumatoid Arthritis affects over 24 million people, mostly adults aged 60 and older.
Data for the Americas and the Caribbean shows that both diseases affect almost 27 million people.
Arthritis and other rheumatic conditions, such as OA, cost the US economy nearly $128 billion per year3 in direct
expenses (medication, hospitalization, etc.) and indirect expenses (disability-associated and early retirement, among
About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus
on the discovery, development and commercialization of prescription medicines for
gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and
infectious disease. AstraZeneca operates in over 100 countries and its innovative medicines
are used by millions of patients worldwide. For more information please visit:
Vlaams Diergeneeskundig Tijdschrift, 2009, 78 Overzichtsartikel 239 Biggencastratie onder verdoving 1S. Van Beirendonck, 1,2B. Driessen, 2R. Geers 1Katholieke Hogeschool Kempen, Cluster Dier&Welzijn, Kleinhoefstraat 4, B-2440 Geel2Zoötechnisch Centrum, K.U.Leuven, Bijzondere weg 12, B-3360 Lovenjoel SAMENVATTING De castratie van biggen staat bekend als een belangrijk economisch