Safety Data Sheet Tretinoin Revision date : 2012/04/18 1. Product and Company Identification 2. Hazards Identification Emergency overview WARNING: CAUSES SKIN IRRITATION. Possible risk of harm to the unborn child. CAN FORM EXPLOSIVE DUST-AIR MIXTURES. Avoid contact with the skin, eyes and clothing. Avoid inhalation of dusts. Wear chemical resistant protective gloves. Wear safety glasses with side-shields. Eye wash fountains and safety showers must be easily accessible. State of matter: solid Colour: yellow Odour: odourless Potential health effects
Primary routes of exposure: Routes of entry for solids and liquids include eye and skin contact, ingestion and inhalation. Routes of entry for gases include inhalation and eye contact. Skin contact may be a route of entry for liquified gases. Acute toxicity: Virtually nontoxic after a single ingestion. Irritation / corrosion: Irritating to skin. Sensitization: No data available concerning sensitizing effects. Chronic toxicity: Carcinogenicity: No data available concerning carcinogenic effects.
Safety Data Sheet Tretinoin Revision date : 2012/04/18 Repeated dose toxicity: No data available concerning repeated dose toxicity. Reproductive toxicity: No reliable data are available concerning reproduction toxicity. Teratogenicity: May cause harm to the unborn child. Genotoxicity: No mutagenic effect was found in various tests with bacteria and mammals. Signs and symptoms of overexposure: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11. Potential environmental effects
Aquatic toxicity: Very toxic to aquatic organisms. Toxic effects occur within the range of solubility. The inhibition of the degradation activity of activated sludge is not anticipated when introduced to biological treatment plants in appropriate low concentrations. 3. Composition / Information on Ingredients CAS Number Content (W/W) Chemical name 4. First-Aid Measures General advice: Remove contaminated clothing. First aid personnel should pay attention to their own safety. If inhaled: Keep patient calm, remove to fresh air, seek medical attention. If on skin: Wash thoroughly with soap and water. If irritation develops, seek medical attention. If in eyes: Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open, consult an eye specialist. If swallowed: Rinse mouth immediately and then drink plenty of water, seek medical attention. Note to physician
Treat according to symptoms (decontamination, vital functions), no known specific antidote.
5. Fire-Fighting Measures
Safety Data Sheet Tretinoin Revision date : 2012/04/18 Suitable extinguishing media: water spray, dry powder Hazards during fire-fighting:
Burning produces harmful and toxic fumes. Dust explosion hazard. Protective equipment for fire-fighting: Firefighters should be equipped with self-contained breathing apparatus and turn-out gear. Further information: Dispose of fire debris and contaminated extinguishing water in accordance with official regulations. 6. Accidental release measures Personal precautions: Avoid dust formation. Environmental precautions: Do not discharge into drains/surface waters/groundwater. May be harmful to the aquatic environment. Prevent entry into drains and surface waters. Cleanup: Avoid raising dust. Dispose of absorbed material in accordance with regulations. For small amounts: Pick up with suitable appliance and dispose of. For large amounts: Pick up with suitable appliance and dispose of. 7. Handling and Storage Handling Protection against fire and explosion: Prevent electrostatic charge - sources of ignition should be kept well clear - fire extinguishers should be kept handy. Avoid dust formation. Avoid whirling up the material/product because of the danger of dust explosion. General advice: Keep container tightly closed and dry. Protect against heat. Protect contents from the effects of light. Storage stability: Storage temperature: <= 25 °C 8. Exposure Controls and Personal Protection
Advice on system design: Ensure adequate ventilation.
Safety Data Sheet Tretinoin Revision date : 2012/04/18 Personal protective equipment Respiratory protection: Breathing protection if breathable aerosols/dust are formed. Hand protection: Chemical resistant protective gloves Eye protection: Safety glasses with side-shields. Body protection: Body protection must be chosen based on level of activity and exposure. General safety and hygiene measures: Under no circumstances should the product come into contact with the skin of pregnant women or be inhaled by them. Hands and/or face should be washed before breaks and at the end of the shift. 9. Physical and Chemical Properties
n-octanol/water (log Pow): Viscosity, dynamic:
10. Stability and Reactivity Minimum ignition energy: 3 - 10 mJ, 1,013 hPa, 20 °C, Inductivity: 0.1 mH (VDI 2263, sheet 1, 2.5) The product is capable of dust explosion. Conditions to avoid: Temperature: > 60 degrees Celsius Avoid light. Substances to avoid: Oxygen Hazardous reactions: No hazardous reactions when stored and handled according to instructions. Decomposition products: Hazardous decomposition products: No hazardous decomposition products if stored and handled as prescribed/indicated. Thermal decomposition: 240 °C, 2.0 K/min (DSC (DIN 51007))
Safety Data Sheet Tretinoin Revision date : 2012/04/18
Oxidizing properties: not fire-propagating (other) 11. Toxicological information
Acute toxicity
Oral: Type of value: LD50 Species: rat (male/female) Value: approx. 8,000 mg/kg (BASF-Test) Aspiration Hazard:
No data available. 12. Ecological Information
Fish Acute: OECD Guideline 203 semistatic Brachydanio rerio/LC50 (96 h): 0.2 mg/l The statement of the toxic effect relates to the analytically determined concentration. Aquatic invertebrates Acute: OECD Guideline 202, part 1 static Daphnia magna/EC50 (48 h): > 0,1 < 0,3 mg/l The product has not been tested. The statement has been derived from products of a similar structure or composition. Microorganisms Toxicity to microorganisms: OECD Guideline 209 aerobic activated sludge/EC20 (0.5 h): > 1,000 mg/l Degradability / Persistence Biological / Abiological Degradation Test method:
OECD Guideline 301 F (aerobic), activated sludge
Not readily biodegradable (by OECD criteria).
Bioaccumulation
Accumulation in organisms is expected. 13. Disposal considerations Waste disposal of substance: Observe national and local legal requirements.
Safety Data Sheet Tretinoin Revision date : 2012/04/18 14. Transport Information Land transport USDOT
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (contains ALL-TRANS-RETINOIC ACID)
Sea transport IMDG
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (contains ALL-TRANS-RETINOIC ACID)
Air transport IATA/ICAO
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (contains ALL-TRANS-RETINOIC ACID)
15. Regulatory Information
Federal Regulations Registration status: Chemical
OSHA hazard category:
EPCRA 311/312 (Hazard categories):
State regulations CA Prop. 65: THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM.
Safety Data Sheet Tretinoin Revision date : 2012/04/18 16. Other Information
NFPA Hazard codes: Health : 2 Fire: 1 Reactivity: 0 Special: none HMIS III rating
NFPA and HMIS use a numbering scale ranging from 0 to 4 to indicate the degree of hazard. A value of zero means that the substance possesses essentially no hazard; a rating of four indicates extreme danger. Although similar, the two rating systems are intended for different purposes, and use different criteria. The NFPA system was developed to provide an on-the-spot alert to the hazards of a material, and their severity, to emergency responders. The HMIS system was designed to communicate workplace hazard information to employees who handle hazardous chemicals. We support worldwide Responsible Care® initiatives. We value the health and safety of our employees, customers, suppliers and neighbors, and the protection of the environment. Our commitment to Responsible Care is integral to conducting our business and operating our facilities in a safe and environmentally responsible fashion, supporting our customers and suppliers in ensuring the safe and environmentally sound handling of our products, and minimizing the impact of our operations on society and the environment during production, storage, transport, use and disposal of our products.
MSDS Prepared by: BASF NA Product Regulations MSDS Prepared on: 2012/04/18 IMPORTANT: WHILE THE DESCRIPTIONS, DESIGNS, DATA AND INFORMATION CONTAINED HEREIN ARE PRESENTED IN GOOD FAITH AND BELIEVED TO BE ACCURATE , IT IS PROVIDED FOR YOUR GUIDANCE ONLY. BECAUSE MANY FACTORS MAY AFFECT PROCESSING OR APPLICATION/USE, WE RECOMMEND THAT YOU MAKE TESTS TO DETERMINE THE SUITABILITY OF A PRODUCT FOR YOUR PARTICULAR PURPOSE PRIOR TO USE. NO WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE. FURTHER, YOU EXPRESSLY UNDERSTAND AND AGREE THAT THE DESCRIPTIONS, DESIGNS, DATA, AND INFORMATION FURNISHED BY OUR COMPANY HEREUNDER ARE GIVEN GRATIS AND WE ASSUME NO OBLIGATION OR LIABILITY FOR THE DESCRIPTION, DESIGNS, DATA AND INFORMATION GIVEN OR RESULTS OBTAINED, ALL SUCH BEING GIVEN AND ACCEPTED AT YOUR RISK. END OF DATA SHEET
DIPARTIMENTO DI NEUROSCIENZE, SALUTE MENTALE E ORGANI DI SENSO - NESMOS CURRICULUM DIDATTICO – SCIENTIFICO – ASSISTENZIALE DEL PROF. ANTONINI Giovanni DATI PERSONALI Nome e Cognome Giovanni Antonini Settore Scientifico-Disciplinare: Neurologia MED/26 ATTUALE POSIZIONE Professore associato dal 2005 presso la Facoltà di Medicina e Psicologia – Univers
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