Nankai University CURRICULUM VITAE Guan-Ping Yu Personal Information
The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China
Mobile Phone: +86-13820101820 Fax: Education Postdoctor Plant Protection, The State Key Laboratory of Elemento-organic
Chemistry, Nankai University, Tianjin, P. R. China.
PS. Directed by prof. Zhengming Li (Academician of the Chinese Academy of Engineering ) Ph.D. Organic Chemistry, Xinjiang Technical Institute of Physics and Chemistry，
Chinese Academy of Sciences, Urumqi, P. R. China.
PS. Directed by prof. Liangzhong Xu and prof. Haji Akber Aisa M.S. Applied Chemistry, Qingdao University of Science and Technology, Qingdao,
The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
Mobile Phone: +86-13820101820 E-mail: yugp2005@nankai.edu.cn
Nankai University B.S. Material Chemistry, Qingdao University of Science and Technology, Qingdao, Research:
1. Design, syntheses, theoretical and biological activity study on new triazole derivatives.
The works include designation (receptor-based design techniques (Sybyl program)) and
synthesis bioactivities compounds, determination of the structure (elemental anal., IR,
MS, 1H NMR and single crystal X-ray diffraction), antifungal test and quantitative
structure-activity relationships study (Sybyl program and Spss software) of new triazole
derivatives. New compounds with higher antifungal activities were selected as lead
compounds for further rational modification.
(1) Synthesis and Fungicidal Evaluation of 2-Arylphenyl
Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives. (J. Agric. Food Chem., 2009,
(2) Synthesis and QSAR Studies on 1-((5-Substituted-1,3,4-
thiadiazol-2-yl)methyl)-1H-1,2,4-triazole as Antifungal Agents(Struct chem, 2009,
(3) A Quantitative Structure-Activity Relationship Study of Antifungal Analogues of
3,4-Substituted 5-((1H-1, 2, 4-triazol-1-yl)methyl)-4H-1,2,4-triazole (Struct Chem.
(1) Product single crystals (Solvent volatilization, Gel diffusion, Co-crystallization et
(2) Determination of the structures (Use SHELXTL for solving single-crystal X-ray
diffraction data sets, be good at refining disorder crystal and determination of
(3) Analysis and expression of the structures (Diamond program, Platon program,
(Chem. Res. Chinese U., 2006, 22(6), 763-764; Chin. J. Struct. Chem. 2006, 25(6),
The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
Mobile Phone: +86-13820101820 E-mail: yugp2005@nankai.edu.cn
Nankai University
673-676; Acta Cryst. 2008. E64, o805)
(1) Carried out a MO calculations using density functional theory (DFT) at B3LYP/6-
31G level (Gaussian 03 software package).
(2) Explain the triazole compounds’ difference activities against a certain fungus via
molecular orbital theory, since variation in biological activity expressed in the form
of percent inhibition is most strongly correlated with energy variation (△EL–H)
between HOMO and LUMO. (Struct chem 2006, 17, 235-239)
4. Pilot-scale experiment for Neonicotinoid Insecticides production
Based on the investigation on the related patents and literature, the synthesis route and
equipments for lab synthesis test were built. In the experiment, the effect of reaction
temperature, feed ratio and reaction residence time (space velocity) on the conversion
ratio of feedstock and the selectivity of product were investigated and the optimized
reaction condition was obtained. On the basis of the lab test results, the design of flow
diagram for pilot test was followed. It includes techniques flow, selection of equipment
and material, enactment of process control and analysis methods, wastes disposal and
safety technology. In addition, the design of the reactor and some separation tower was
emphasized. The pilot equipment was built and the related pre-experiment was done.
The results show the design for pilot test was reliable.
(1) Pilot-scale experiment“Synthesized Thiacloprid”
(2) Pilot-scale experiment “Synthesized Clothianidin”
5. Design, syntheses and insecticidal of new Nereistoxin derivatives.
Nereistoxin is a neurotoxic principle isolated by Nitta in 1934 from a marine annelid.
Among a series of neristonxin (NTX) analogs, Cartap, bensultap and thiocyclam have
been commercialized. Our studies are aimed to obtain a new type of insecticides that are
related to NTX and more chemically stable than the above mentioned insecticide.
Scholarships
2006.05 Honor to receive the title of "the outstanding graduate of Qingdao University of
Science & Technology" (less than 1% of all graduated students of Qingdao University of
The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
Mobile Phone: +86-13820101820 E-mail: yugp2005@nankai.edu.cn
Nankai University
2003.07 Qingdao University of Science and Technology, four years obtains "the healthy,
studious, and helpful student", continuously the title (2% of all students of College of
Publications
1. Guan-Ping Yu, Liang-Zhong Xu*, Xu Yi, Wen-Zhao Bi, Qi Zhu, Zhi-Wei Zhai. Synthesis
and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
Derivatives. J. Agric. Food Chem., 2009, 57, 4854–4860
2. Guan-Ping Yu, Wen-Zhao Bi, Guo-Dong Si, Ya-Xun Yang, Haji Akber Aisa,
Liang-Zhong Xu*, Synthesis and QSAR Studies on 1-((5-Substituted-1,3,4-
thiadiazol-2-yl)methyl)-1H-1,2,4-triazole as Antifungal Agents, Struct Chem, 2009, 20,
3. Liang-Zhong Xu*, Guan-Ping Yu, Wen-Zhao Bi, Haji Akber Aisa. A Quantitative
Structure-Activity Relationship Study of Antifungal Analogues of 3,4-Substituted 5-((1H-1,
2, 4-triazol-1-yl)methyl)-4H-1,2,4-triazole, Struct Chem. 2008, 19, 959-965.
4. Liang-zhong Xu*, Guan-ping Yu, Zhong-jie Xu, Zhang Gong-sheng, Zhi-wei Zhai.
Synthese, Crystal Structure of 2-tert-Butyl-5-(4-tert-butylbenzylthio)-4-chloropyridazin-3
(2H)-one, Chem. Res. Chinese U., 2006, 22(6), 763-764
5. Liangzhong Xu*, Yongwei Huang, Guan-Ping Yu,Guodong Si, Qi Zhu
Experimental, Theoretical and Biological Activity Study on new 1H-1,2,4-triazole
compounds, Struct chem, 2006,17, 235-239
6. Liang-Zhong Xu*, Yu-Qing Shang, Guan-PingYu, Kai Li, Guo-Dong Si. Synthesis and
Crystal Structure of 5-[(1H-1,2,4-Triazol-1-yl)methyl]-4-(2,3-dimethoxybenzylideneamino)
-2H-1,2,4-triazole-3(4H)-thione Monohydrate, Chin. J. Struct. Chem. 2006, 25(6), 673-676
7. Liangzhong Xu*, Zhiwei Zhai, Guan-Ping Yu, Qi Qin Yong, Ya-Xun Yang. Synthese and
Biological Activities of Novel Benzotriazole Compounds Containing a Thioamide Group,
Chem. Res. Chinese U., 2006, 22(5), 574-576
8. Liang-zhong Xu*, Wei-hua Li, Guan-ping Yu, Yong-qi Qin, Shuang-hua Yang and
Bao-rong Hou. Structure and Biological Activities of
2-(1,3-Dithiolan-2-ylidene)-1-phenyl-2- (1,2,4-triazol-1-yl)ethanone, Chem. Res. Chinese
The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
Mobile Phone: +86-13820101820 E-mail: yugp2005@nankai.edu.cn
Nankai University U.,2005, 21(5), 528-530
9. Fang-Fang Jian, Hai-Lian Xiao, Liang-Zhong Xu, Guan-ping Yu. Synthesis and biological
activities of some 2-(substituted-phenyl)-2-methyl-4-(1,2,4-triazole-1-yl)methane-1,3-
dioxolane derivative. J. Indian. Chem. Soc. 2004, 81(11), 974-977
10. Liangzhong Xu*, Fangfang Jian, Yongqi Qin, Guan-ping Yu, Kui Jiao. Structure and
Biological Activities of 3-phenyl-2-[1-benzoyl-1-(1,2,4-triazol-1-yl)] Methenyl
Thiazolidine, CHEM. RES. CHINESE U. 2004, 20(3), 305-307
1. Fangfang Jian, Liangzhong Xu, Zhiqiang Hu, Qi Zhu, Guan-ping Yu, Synthese and
Biological Activities of Novel triazole Compounds Containing a aromatic ether group,
2. Liangzhong Xu, Hualong Wu, Zhiqiang Hu, Qi Zhu, Guan-ping Yu, Wenzhao Bi,
Synthesis ditriazole compounds containing aromatic ether group and use, (2006),
3. Liangzhong Xu, Fangfang Jian, Guanping Yu, Kai Zhou, The preparation and application
of 2-chloro-ethyl phosphonate zinc, (2005), CN1861613
4. Liangzhong Xu, Fangfang Jian, Guanping Yu, Yaxun Yang, A micro emulsion containing
propiconazole and its preparation method, (2005), CN1860877
5. Liangzhong Xu, Fangfang Jian, Guanping Yu, A wettable powder containing Phoxim and
The State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
Mobile Phone: +86-13820101820 E-mail: yugp2005@nankai.edu.cn
Insulinoma How to Recognize It and Emergency Treatment Insulinomic ferrets may just act a little tired, lethargic. Their back legs may wobble. They may seem "out of it" and stare at nothing. They may feel nauseous. Some let you know by pawing at their mouths. More severe symptoms include seizures or comas, which are life threatening, of course. If an Insulinomic ferret is comatose
In the Market Garden at the UCD Student Farm we operate a community supported agriculture system (CSA), which provides a basket full of fruits and vegetables to 65 on-campus subscribers for approximately 46 weeks of the year. Our CSA serves three purposes. First, it provides a mechanism for educating students about a wide variety of vegetables in an experiential learning setting. Secondly, it
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