OSummeLr 2003OGY ROBOTIC RADICAL PROSTATECTOMY COMES TO DUKE
Even though radical prostatectomy remains the gold
procedure is performed in the same way as the LRP but
standard for the treatment of localized prostate cancer, the
with the assistance of a daVinci robotic surgical system
radical retropubic prostatectomy (RRP) and radical per-
(Intuitive Surgical, Inc., Mountain View, CA). This system
ineal prostatectomy (RPP) are still associated with signifi-
has revolutionalized the way that some centers are
cant side effects. Both of these operations have become far
approaching minimally invasive urology around the world.
less morbid with the extensive experience of urologists
It allows the surgeon to perform the operation while sitting
around the world. Improvements in transfusion rates, hos-
at a console. This console is equipped with 3-dimensional
pital stay, recovery time, erectile dysfunction rates, and uri-
visibility, allowing for precise anatomical identification of
nary incontinence rates have been remarkable, but they
key structures, including small blood vessels and the nerves
remain significant enough that many patients are pursuing
that drive erectile function. The surgeon also controls two
was first attempted in the early 1990’s and wasabandoned because it was found to be techni-cally too demanding. This was especially truewhen it came to the reconstructive aspect of theprocedure. It wasn’t until the mid 1990’s that afew European institutions established LRP as afeasible surgical approach. Centers in theUnited States then began to reassess the viabil-ity of this technically demanding procedure andvalidated the findings in France. Most of thesecenters came to the same conclusion that LRPwas feasible and offered significant benefits topatients once the surgeon made it through the
initial learning curve. The advantages of theprocedure included decreased blood loss, decreased trans-
robotic arms that have a full range of motion, allowing for
fusion rates, decreased pain medication use, and improved
much easier dissection and reconstruction as compared to
recovery times and they occurred while preserving equiva-
standard laparoscopy. In addition, the reconstruction per-
lent oncologic results. In addition, some centers have
formed with the robot is superior to the reconstruction
reported improvements in urinary continence and erectile
performed during open surgery. There is no question that
dysfunction rates with LRP. It is the initial learning curve
the robot provides tremendous advantages to the surgeon
of LRP that has been a topic of extensive debate, with
in terms of ergonomics and surgeon exhaustion, which
many feeling that the technical difficulty of this operation
allows him to focus completely on the operation without
restricts its widespread applicability.
the physical demands that come with LRP. The surgeon is
Robotic Radical Prostatectomy (RobRP) may be the
also assisted by a laparoscopic surgeon at the bedside as
answer to the technical challenges presented by LRP. This
A B i - A n n u a l P u b l i c a t i o n o f t h e D i v i s i o n o f U r o l o g y , D u k e U n i v e r s i t y M e d i c a l C e n t e r , D u r h a m , N C
ROBOTIC RADICAL PROSTATECTOMY continued
Since coming to Duke just two years ago, Dr. David
W. Patrick Springhart, who all bring vast laparoscopic expe-
Albala has managed to bring laparoscopic urology into the
rience and interest to the program, which has been invalu-
mainstream at Duke University Medical Center. Along
able in the birth of the robotic prostatectomy program.
with his team, Dr. Albala has performed over 200 laparo-
Duke University Medical Center is now one of the few cen-
scopic urologic operations. These have included nephrec-
ters in the country offering all surgical options to prostate
tomies, nephroureterectomies, partial nephrectomies,
pyeloplasties, cyst decortications, and other renal andureteral reconstructive procedures. Together, with the rest
"Urologists are becoming increasingly skilled in
of the Duke Urology faculty, he continues to build an all-
minimally invasive techniques to treat cancer. These
inclusive minimally invasive urologic center that is focused
advances underscore the need to merge the unique skills
on innovative treatments for all urologic diseases. Hisextensive laparoscopic experience has proven invaluable
and perspectives of the endourologist and urologic
for the initiation of the Robotic Prostatectomy program at
oncologist. With the marriage of laparoscopy and
Duke University Medical Center. Initial patient feedback
oncology in daily practice, we may soon witness
has been excellent, with the first patient being discharged
the birth of laparoscopic urologic oncology as a
Dr. Albala is Co-Director, together with Dr. Glenn
Preminger, of the Laparoscopic and Endourologic
– From Leonard Gomella’s Editorial: Laparoscopy
and Urologic Oncology – I Now Pronounce you
Fellowship Program here at Duke. Their current Fellows
Man and Wife. J Urol 169: 2057-2058, 2003.
are Dr. Yeh Hong Tan, Dr. James O. L’Esperance, and Dr. PROSTATE CANCER FORUM: BREAKING NEWS by Philipp Dahm, M.D., Assistant Professor, Duke UrologyThe Role of Finasteride in the
indiscriminate use of Finasteride as an agent to reduce the
Prevention of Prostate Cancer
A recent article published in the New England Journal ofDetection of Lymph Node Metastasis Medicine suggests that Finasteride may have a potential role
by MRI with Nanoparticles
in the prevention of prostate cancer (N Engl J Med 349(3):215-224, 2003). In this headline-making article Thompson
A further noteworthy paper in the same journal
et al. report the findings of a prospective placebo-con-
recently reported on a new imaging modality for detecting
trolled clinical trial that randomly assigned 18,882 men to
lymph node involvement in patients with prostate cancer
treatment with Finasteride (5 mg daily) or placebo for the
(N Engl J Med 348(25): 2491-2499, 2003). Magnetic reso-
duration of seven years. They found that significantly
nance imaging (MRI) with lymphotropic superparamag-
lesser patients in the Finasteride group compared to the
netic nanoparticles was performed in 80 patients who
placebo group (18.4% versus 24.4%) were diagnosed with
subsequently underwent formal pelvic node dissection.
prostate cancer. Additionally, among those patients diag-
Thirty-three patients (41%) were found to have positive
nosed with prostate cancer, a high Gleason score disease
nodes that were all preoperatively identified using this
(Gleason score > 7) was twice as common in the
enhanced MRI technique. The sensitivity of identifying a
Finasteride than the placebo group (37.0% versus 22.2%).
single positive node by MRI with nanoparticles was vastly
The reason behind the increased prevalence of high grade
superior to MRI alone (90.5% versus 35.4%). The positive
disease in the Finasteride group remains poorly under-
predictive value of identifying a positive individual lymph
stood. Gleason scoring bias, the induction of high grade
node was 95.0%. The authors suggest that MRI with
disease or the selective inhibition of low-grade tumors may
nanoparticles may – if these results are confirmed in a
all play a role. The study fails to answer the question
larger study – provide important preoperative staging
whether Finasteride indeed prevents prostate cancer or
information that may make staging node dissection unnec-
merely delays or alters its presentation. Pending further
evidence, it appears prudent to caution patients against an
D U K E U R O L O G Y T O D AY DUKE UROLOGY SAYS FAREWELL TO TWO OF ITS FINEST
After six years of service to Duke Urology, Dr.
John S. Wiener has accepted a position as Chief of Urologyat the University of Mississippi Medical Center. Dr. Wienerjoined our faculty in 1997 after completing his undergradu-ate studies and urology residency at Duke and a fellowshipwith Dr. Edmond Gonzales at Texas Children’s Hospital. Upon his return to Duke, Dr. Lowell King retired after a dis-tinguished career as Head of Pediatric Urology and Dr. Wiener assumed his position. Since that time, he has givencountless hours of devotion to expanding the clinical prac-tice of pediatric urology at Duke to its current level. Dr. Wiener’s commitment to patient care, presented withgenuine caring, and his energetic, well-rounded approach
Dr. Wiener crowns Gloria Perry, “Queen of Cath”
Friend and co-worker, Beth Stewart, Director of
During a celebration at the Searle Center on May 19,
Advanced Practice Nursing says of Gloria, “She has
2003, friends, family, and co-workers gathered to celebrate
literally touched the lives of thousands of patients
the retirement of Gloria Perry, R.N. after 35 years of service
and families through her remarkable clinical expertise,
to Duke. Gloria’s career began in 1968 when she joined the
her tender touch, her excellent teaching, and her
Urology Clinic as a Staff Nurse. In 1972, Gloria was pro-
compassion as she’s helped many cope with and adjust to
moted to Head Nurse of the clinic and in 1975 she received
life-altering and body-changing procedures. Her patient’s
an appointment as Urology Nurse Clinician. The remainder
have described her as a “gift from God.” Talk with her for
of her career at Duke was spent with the Department of
even a few minutes and you’ll find one of the most unassum-
ing, deeply spiritual, caring individuals, not just in nursingbut on this earth.”
UROLOGY RESIDENCY TRAINING PROGRAM Highlights 2003 Duke Urology Graduates Bertram A. Lewis, Jr., MD, Jeffrey J. Sekula, MD Dinesh S. Rao, MD Ning Z. Wu, MD, Ph.D. Pictured left to right: Dinesh S. Rao, MD, Ning Z. Wu, MD, Ph.D., Bertram A. Lewis, Jr., MD, Ph.D, and Jeffrey J. Sekula, MDADDITIONAL RESIDENT HONORS AND AWARDS Costas D. Lallas, M.D. received the Pfizer Scholar Award. Jeffrey J. Sekula, M.D., Fernando C. Delvecchio, M.D. and Costas D. Lallas, M.D. received Academic Ganesh V. Raj, M.D., Ph.D. received 2nd place for “Excellence in Urological Clinical Case Presentation” at the Annual Alon Z. Weizer, M.D. received 3rd place for “Excellence in Urological Research Case Presentation” at the Annual DUKE HEALTH CENTER MOVES TO NEW LOCATION
Duke Health Center, formerly known as the Duke Community Urology Center, has moved to a new location at 3116
North Duke Street in Durham. Duke urologist’s Thomas J. Polascik, M.D. and Brian C. Murphy, M.D. are Co-Directors of this specialty practice that was established in 1998 to provide urological evaluation and treatment to the Durham community. Hours of operation are Monday thru Friday from 8:30 am to 5:00 pm. Appointments can be scheduled by calling (919) 684-2446. Duke Health Center 3116 North Duke Street Durham, NC 27704 Phone: 919-660-2200 Kudo’s ……………. Cary N. Robertson, M.D., Associate Professor of Urology and John S. Wiener, M.D., Associate Professor of
Urology and Assistant Professor of Pediatrics were named “Top Doctors in Urology for the Triangle Area” in the July2003 issue of Business North Carolina. Information for this listing was compiled by a non-profit research organization thatsent questionnaires to nearly all physicians in the Charlotte, Triad and Triangle areas of the State. Each physician wasasked to recommend the specialists they would consider as “most desirable for care of a loved one.” The doctors chosenwere named by the largest numbers of their peers. Wendy Demark-Wahnefried, Ph.D., Associate Professor of Urology, received the 2003 Komen Professor of
Survivorship Award from the Susan G. Komen Breast Cancer Foundation. Established in 1999, this award recognizes and rewards efforts and achievements that improve the overall quality of life for breast cancer survivors.
The Urology Clinic Staff was one of four Duke outpatient clinics recognized during National Patient Advocacy
Week (April 13-18, 2003) for their outstanding team approach in creating excellent patient service and patient advocacy. D U K E U R O L O G Y T O D AY 2003 HAND ACCESS LAPAROSCOPIC NEPHRECTOMY TRAINING SEMINARS Duke University Medical Center Durham, NC Course Director: David M. Albala, M.D. Professor of Urology
➤ April 18
➤ June 6 (Advanced Hand-Assist procedures)
➤ July 12
➤ August 8
➤ September 12
➤ October 10
➤ November 21
➤ December 5 (Advanced Hand-Assist procedures)
For further information or to register for the course, please contact:
Allison Benjamin
Applied Medical • 22872 Avenida Empresa • Rancho Santa Margarita, CA 92688
FUTURE CONFERENCES 1:00-6:00 pm 1:00-6:00 pm thru 2/7/04 thru 3/14/04 For more information, please call us at (919) 684-2033 or visit our website: www.dukeurology.com D U K E U R O L O G Y T O D AY
919-684-2033 (Administrative Office)919-684-4611 (Fax)
DIVISION OF UROLOGY CLINICAL FACULTY David F. Paulson, M.D. Bertram A. Lewis, Jr., M.D., Ph.D. Cary N. Robertson, M.D. Specialty: Urologic Oncology & General
David M. Albala, M.D., F.A.C.S. Johannes Vieweg, M.D. Brian C. Murphy, M.D. Specialty: Endourology & Minimally
Specialty: Urologic Oncology & General
Specialty: Urologic Oncology &
Cindy L. Amundsen, M.D. Assistant Professor of Obstetrics & Thomas J. Polascik, M.D., F.A.C.S. Philip J. Walther, M.D., Ph.D., F.A.C.S. Specialty: Urologic Oncology & General
Associate Professor of PathologySpecialty: Urologic Oncology
Philipp Dahm, M.D. Glenn M. Preminger, M.D. George D. Webster, M.B., F.R.C.S. Specialty: Urologic Oncology &
Specialty: Nephrolithiasis & Minimally
Specialty: Reconstructive & Female
Craig F. Donatucci, M.D. Associate Professor of Urology Specialty: Male Infertility & Sexual Duke Urology Today is published twice a year by the Division of Urology at Duke University Medical Center. Comments and inquiries are welcome and should be sent to: For more information, Joan McAlexander, Editor please visit our website at www.dukeurology.com DUMC 3707 Durham, North Carolina 27710
Prostaglandins, Leukotrienes and Essential Fatty Acids 74 (2006) 17–21Supplementation with flax oil and vitamin C improves the outcome ofAttention Deficit Hyperactivity Disorder (ADHD)Kalpana Joshia,Ã, Sagar Ladb, Mrudula Kalea, Bhushan Patwardhana, SahebraoP. Mahadikc, Bindu Patnib, Arti Chaudharyb, Sheila Bhaveb, Anand PanditbaInterdisciplinary School of Health Sciences (ISHS), U
Current Drug Targets - CNS & Neurological Disorders , 2003, 2, 357-362 Exploring Genetic Influences on Cognition: Emerging Strategies for Target Validation and Treatment Optimization John A. Fossella*, Sonia Bishop and B.J. Casey The Sackler Institute for Developmental Psychobiology, Weill Medical College Cornell University, 1300 York Ave,New York, NY 10021, USA Abstract: Geno