La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.
Microsoft word - biology presenters.doc
April 25, 2007
Biology Presenters
Student: Amber Gaither “Nested PCR to Amplify the Plasmodium falciparum Mentor: Christopher Plowe Chloroquine Resistance Transporter (PfCRT)in Samples Oral Presentation, UC 312 from Clinical Trials in Malawi” 9:30 - 9:45 AM
Student: Uzoma Iheagwara “Uveal Melanoma Vaccines Express Major Mentor: Suzanne Ostrand- Histocompatibility Class II Molecules in the Absence of Rosenberg Invariant Chain” Oral Presentation, UC 312 9:45 - 10:00 AM Student: Shayla Shorter “TRAIL Enhances Autoantibody Production and Renal Mentor: Violeta Rus Disease in Chronic Graft-versus Host Disease” Oral Presentation, UC 310 1:45 - 2:00 PM
9:30 – 11:30 AM Poster Session in UC Ballroom Student: Manar Abdelkader “Analysis of Transposon Mobility and Identification of Mentor: Steve Miller Additional gls genes in Volvox carteri” Student: Anthony Agyapong “Activity of Promoter Regions Critical in hZip1’s Role in Mentor: Renty Franklin Prostate Cancer” Student: Christopher Bednarek “CR-nitA: the Synthesis of a Selectable Marker for Mentor: Stephen Miller Volvox carteri Transformations ” Student: Ramon Cabrera “A Genetic Approach to Identify Targets of Ubiquitin Mentor: Mauricio Bustos Ligases from Animals and Plants” Student: Nancy Chiles “Sequencing the Melanopsin Gene from Bovine Retina” Mentor: Phyllis Robinson Student: Foyin Fasanmi “Comparison of Markers of Disease Severity in Patients Mentor: Steven Johnson with Sepsis and Matched Controls” Student: Adrian Feijoo “Phosphodiesterase 2-Labeled Atypical Glomeruli and Mentor: Weihong Lin Sensory Neurons in the Olfactory System” 9:30 – 11:30 AM Poster Session in UC Ballroom (continued) Student: Ayanna Flegler “Differential Gene Expression in Cultured Rodent Mentor: Lasse Lindahl Malaria Parasite” Student: Marcus Gillis “Parkinsonism Development in Cycad-Fed Rats” Mentor: Paul Yarowsky Student: Lynna Kiere “Reconstructing Carotenoid Color Evolution in Mentor: Kevin Omland Caciques” Student: Chinyere Nwaneri “The Localization of Parvalbumin in the Human Mentor: Rosalinda Roberts Prefrontal Cortex: A Light and Electron Microscopic Study” Student: Frances Onyimba “The Neurotoxic Effects of Glutamate on Neonatal Rats” Mentor: Margaret McCarthy Student: Carlita Phillip “Determination of Spatial and Temporal Location of Mentor: David Eisenmann Candidate Bar-1 Target Genes in Caenorhabditis elegans during Development” Student: Charlie Rutter “Detection of Hsp90α, a Circulating Isoform of Hsp90, in Mentor: Angelkia Burger Plasma from Tumor-Bearing Mice and Patients” 1:00 – 3:00 PM Poster Session in UC Ballroom Student: Roderick Bautista “Localization of an Inhibitory Region in the hZIP1 Mentor: Renty Franklin Promoter” Student: LaToia Bryant “Characterizing L4 and L22 Mutations in E.coli Strains Mentor: Janice Zengel Resistant to Oleandomycin Triacetate” Student: Jenélle Dowling “Low Return Rates and Pairing Infidelity in Two Mentor: Kevin Omland Maryland Oriole Species” Student: Ejiofor Ezekwe “Olfactory Epithelial Cell Degradation in Mice with Mentor: Weihong Lin Surgically Occluded Nostrils” Student: Whitney Fields “Isolation of Mutations in L4 and L22 That Confer Mentor: Janice Zengel Resistance to the Antibiotic Tylosin” April 25, 2007
Biology Presenters 1:00 – 3:00 PM (continued) Student: Tiffany Fleet “Analyzing the Interactions between RNase MRP and Mentor: Lasse Lindahl XRN-1 in Order to Further Investigate RNA Metbolism Student: Shilpa Gadwal “The Effects of High-Level Troleandomycin Resistance Mentor: Janice Zengel Mutations in rRNA of Deinococcus radiodurans on Ribosome Function” Student: Darryl Gaines “Novel Protein Secretion Systems in Bordetella Mentor: Nicholas Carbonetti parapertussis” Student: Jamie Heard “A Novel System for Inducible Gene Expression in the Mentor: Charles Bieberich Prostate” Student: Tamika John “B-Cell Delivered Gene Therapy for Tolerance” Mentor: David Scott Student: Vovanti Jones “Investigating Potential Second Site Suppressors in the Mentor: Daphne Blumberg Amp A Pathway in Dictyostelium discoidium” Student: Bettel Mussie “Sex Differences in the Expression of Calcium Mentor: Margaret McCarthy Transporters in the Hypothalamus” Student: Kelechi Ndubuizu “Gene Expression of Omentin 1/2 in Stromal Vascular Mentor: John McLenithan Cells of Adipose Tissue” Student: Peter Parker “Visualization and Analysis of RNase MRP in Mentor: Lasse Lindahl Saccharomyces cerevisiae using Optimized Tetracystine Tagging of SNM1p” Student: Steven Tuyishime “Spiramycin-resistant Mutations in Escherichia Coli L4 Mentor: Janice Zengel and L22”
Consumer activism, genetic information, andsocial networking technologies are creating Repurposing with a Difference many opportunities for drug repurposing. Mark S. Boguski,1* Kenneth D. Mandl,2 Vikas P. Sukhatme3 There is widespread belief that current number ofremarkable examples of repur- gerous side effects became tragically evidentin the late 1950s and early 1960s only afterwere
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