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Mmc clinical trials_apr05

Memorial Medical Center1700 Coffee RoadModesto, CA 95355(209) 572-7237 Clinical Trials April 2005
BREAST:
IBCSG

A Phase III Trial Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane as Adjuvant Therapies for PremenopausalWomen with Endocrine Responsive Breast Cancer.
A Randomized Phase III Trial of Exemestane vs. Anastrozole With or Without Celecoxib in Postmenopausal Women with Receptor PositivePrimary Breast Cancer (** temporarily closed to accrual).
Quality of Life Companion Study for MA.27 (NEW)
A Clinical Trial Comparing Anastrozole with Tamoxifen in Postmenopausal Patients with Ductal Carcinoma In-Situ (DCIS)Undergoing Lumpectomy with Radiation Therapy.
A Phase III Adjuvant Trial Comparing Three Chemotherapy Regimens in Women with Node-Positive Breast Cancer: Docetaxel/Doxorubicin/Cyclophosphamide (TAC); Dose-Dense (DD) Doxorubicin/Cyclophospha-mide Followed by DD Paclitaxel (DD AC P); DD AC Followed byDD Paclitaxel Plus Gemcitabine (DD AC PG).
Phase III Trial of Observation +/- Tamoxifen vs. RT +/- Tamoxifen for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast.
Phase III Trial of Continuous Schedule AC + G vs. Every 2 WeekSchedule AC, Schedule AC, Followed by Paclitaxel Given Either Every 2Weeks or Weekly for 12 Weeks as Post-Operative Adjuvant Therapy inNode-Positive or High-Risk Node Negative Breast Cancer.
Phase III Trial of Doxorubicin and Cyclophosphamide (AC) Followed byWeekly Paclitaxel With or Without Trastuzumab as Adjuvant Treatment forWomen with HER-2 Overexpressing or Amplified Node Positive or High-Risk Node Negative Breast Cancer.
GASTROINTESTINAL:
N0147

A Randomized Phase III Trial of Irinotecan (CPT-11) and/or
Oxaliplatin (OXAL)

Plus 5-Fluorouracil (5-FU)/Leucovorin (CF) with or Without Cetuximab(C225) after Curative Resection for Patients with Stage III Colon Cancer.
Intergroup Randomized Phase III Study of Postoperative Irinotecan, 5-Fluorouracil and Leucovorin vs. Oxaliplatin, 5-Fluorouracil andLeucovorin vs. 5-Fluorouracil and Leucovorin for Patients with Stage IIor III Rectal Cancer Receiving Either Preoperative Radiation and5-Fluorouracil or Postoperative Radiation and 5-Fluorouracil(** temporarily closed to accrual).
A Randomized Phase III Study of Gemcitabine in Combination withRadiation Radiation Therapy versus Gemcitabine Alone in Patients withLocalized, Unresectable Pancreatic Cancer.
A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, andRadiotherapy vs. 5-Fluorouracil, Cisplatin and Radiotherapy in Carcinomaof the Anal Canal.
CALGB Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of
80101
Gastric or Gastroesophageal Adenocarcinoma.
CALGB A Randomized Phase III Trial of Gemcitabine plus Bevacizumab vs.
80303
Gemcitabine plus Placebo in Patients with Advanced Pancreatic Cancer.
GENITOURINARY:
JPR.7

Phase III Randomized Trial Comparing Intermittent vs. ContinuousAndrogen Suppression for Patients with Prostate-Specific-AntigenProgression in the Clinical Absence of Distant Metastases FollowingRadiotherapy for Prostate Cancer.
LYMPHOMA:
E2496

A Randomized Phase III Trial of ABVD vs. Stanford V +/- Radiation Therapyin Locally Extensive and Advanced Stage Hodgkin’s Disease.
Randomized Phase III Trial Comparing Two Different Rituximab DosingRegimens for Patients with Low Tumor Burden Indolent non-Hodgkin’sLymphoma.
SKIN:
S0331

A Phase II Trial of STI-571/Imatinib (Gleevec) in NeuroendocrineCarcinoma of the Skin (Merkel Cell Carcinoma).
SYMPTOM MANAGEMENT:
E1Z01

Study of Epoetin Alpha vs. Epoetin Alpha with Dexamethasone inHormone Refractory Prostate Cancer Patients: Impact on Anemia,Fatigue, Functional Status and Quality of Life.
THORAX:
BR.19

A Phase III Prospective Randomized, Double-Blind, Placebo-ControlledTrial of the Epidermal Growth Factor Receptor Antagonist, ZD 1839(IRESSA) in Completely Resected Primary Stage IB, II, IIIA Non-SmallCell Lung Cancer.
A Phase III Trial of Carboplatin, Paclitaxel and Thoracic Radiotherapy,With or Without Thalidomide, in Patients with Stage III Non-Small CellLung Cancer.
Phase III Chemoprevention Trial of Selenium Supplementation in Personswith Resected Stage I Non-Small Cell Lung Cancer.
For any additional information regarding the above Clinical Trials, contact Denise Galbawy RN, Cancer Research Coordinator, at 572-7116.

Source: http://www.memorialmedicalcenter.org/images/MMC%20Clinical%20Trials_Apr05.pdf

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