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The role of energocorrection of asthenoneurotic syndrome in different neurologic disorders

Abstracts / Journal of the Neurological Sciences 333 (2013) e537–e578 Objective: To relate GABA changes to motor relearning after stroke through the use of j-difference edited Magnetic Resonance Spectros- Methods: 21 patients (3–12 months post stroke) and 21 healthy, The role of energocorrection of asthenoneurotic syndrome age-matched subjects were recruited. Patients had mild to moderate hand impairment, and fulfilled the criteria for Constraint-Induced E. Silina, S. RumiantsevaV. , V. Afanas'eA. Orlova, Movement Therapy (CIMT). Patients completed two weeks of CIMT, and were scanned before and after training. For MRS a 2 × 2 × 2 cm aI.M. Sechenov First Moscow State Medical University, Russia; voxel was placed on the “hand knob” in the affected hemisphere of bThe Russian National Research Medical University named after N.I.
the patients and in the dominant hemisphere of the healthy subjects.
Pirogov, Russia; cRehabilitation Center for Handicapped “Preodolenie”, GABA was expressed as a ratio to Creatine (Cr). Motor function was measured using the Wolf Motor Function Test (WMFT).
Results: GABA/Cr was significantly lower (p b 0.001) in patients (0.33) Objective: To evaluate the prevalence of asthenic syndrome in patients at baseline compared to healthy subjects (0.42). After therapy, patients with different general medical conditions and neurologic disorders.
showed a significant improvement in hand function (p b 0.001), Patients and methods: 171 patients with different peripheral nervous which was negatively correlated with GABA/Cr changes (R = −0.57, system disorders receiving inpatient treatment at hospitals were p = 0.015) — larger improvements in patients were associated with included (mean age 36.9 ± 8.1 years). Screening revealed the presence greater reductions in GABA/Cr. Results were also significant after of asthenoneurotic syndrome (ANS) of different severity in 120 patients correcting for changes in intracortical grey matter volume.
(70.6%) aged 25–56 years. To evaluate the dynamics of ANS complex Conclusion: A decrease in GABA levels appears to facilitate motor monitoring was performed on days 1 and 25, including analysis of recovery after stroke. GABA, as measured non-invasively with MRS, complaints, assessment of physical and neurologic status, and electro- could be a biomarker for neuronal plasticity during recovery and encephalography (EEG-neurokartograf MBN-20). The intervention group received conventional therapy plus energocorrector and antiox-idant antihypoxant cytoflavin (n = 63) 2 tabs twice a day for 25 days.
The control group received conventional therapy plus placebo (n = 108)according to the same regimen.
Results: 28.1% of the patients with ANS demonstrated marked personality accentuation with anxiety and excitable traits. At day 25 in the interven- tion group 44.4% of the patients demonstrated no asthenic symptoms, 31.8%—only mild symptoms, 15.9%—moderate symptoms and 7.9%— Amantadine treatment of aphasia after stroke severe symptoms (р b 0.001). The control group showed an insignificantimprovement (р = 0.257). There was a positive trend in the subscales K. Severinsen, A. Pedersen. Neurology, Hammel Neurorehabilitation “anxiety” and “depression” with a strong correlation with asthenia and Research Centre, Aarhus University, Hammel, Denmark reduction in the intervention group (r N 0.5; р b 0.05). There was also animprovement in EEG indices—an increase in α-rhythm from 23% to 46% at Background: Amantadine hydrochloride has been used as a central day 25 in the intervention group (p b 0.05). Overall improvement was stimulating pharmacological agent for treatment of disordered registered in 88.9% of the patients, in the control group—27.8% (p b 0.05).
consciousness in patients with traumatic injury, but not for stroke Conclusion: Energocorrection therapy in ANS results in a significant patients suffering from aphasia and other cognitive deficits in the decrease in asthenic and neurotic symptoms.
domains of execution, attention and processing speed.
Objective: To evaluate the effect of short term amantadine treatment on aphasia in subacute stroke patients suffering from aphasia andother cognitive deficits in the domains of execution, attention andprocessing speed.
Materials and methods: Nine subacute stroke patients (age 30– 69 years, time since onset 32–150 days) suffering from aphasia and various other stroke sequelae, receiving inpatient neuro-rehabilita- Power effective electrical stimulation of frog's tion, completed the cohort study. No blinding was attempted and the tibial-gastrocnemius preparation for 200-s continuous intervention was not placebo controlled. Participants were treated with amantadine (50 mg × 2 on days 1–2 and 100 mg × 2 on days W.-Y. Ho, H. van der Merwe, Y.-K. Huang, F.-S. Jaw. Institute of 3–7) in order to ameliorate cognitive deficits. Participants were Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ROC evaluated for changes in the severity of aphasia by application of theWestern Aphasia Battery (WAB), the WAB Aphasia Quotient (WAB-AQ) Background: Electrical nerve stimulation (ENS) is not widely adopted in clinical therapy due to a lack of standard and verification of efficacy.
Results: Amantadine treatment improved the verbal performance as A previous study shows that ENS is beneficial to prevent atrophy.
measured by the WAB-AQ by 11 points (CI95%: 6.7; 15.3), p b 0.0001.
Nevertheless, nerve fibrosis might occur if the pulse frequency exceeds The verbal performance after the subsequent three days of amanta- 40 Hz. For effective standing, various muscles need to maximally dine wash-out was decreased by 5.1 (0.6; 9.6), p = 0.028 on the contract for more than 200 s. Therefore, an ENS protocol should be Conclusion: Treatment with amantadine seems to improve verbal Materials and methods: The contraction force (CF) of the gastrocnemius performance in patients suffering from aphasia after stroke. This is a of frogs was measured and digitized for processing. An adjustable pulse preliminary pilot trial and interpretation of the results must be made was used to achieve a 200-s continuous maximum contraction (CMC) with caution until further studies are performed.
with minimal power delivery. The maximum contraction force wasobtained by the interpolated twitch technique.
Results and discussion: Our data show that the best ENS protocolfor 200-s CMC is 8 Hz, 120 mV, and 35% duty cycle. Compared with


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