The role of energocorrection of asthenoneurotic syndrome in different neurologic disorders
Abstracts / Journal of the Neurological Sciences 333 (2013) e537–e578
Objective: To relate GABA changes to motor relearning after stroke
through the use of j-difference edited Magnetic Resonance Spectros-
Methods: 21 patients (3–12 months post stroke) and 21 healthy,
The role of energocorrection of asthenoneurotic syndrome
age-matched subjects were recruited. Patients had mild to moderate
hand impairment, and fulﬁlled the criteria for Constraint-Induced
E. Silina, S. RumiantsevaV. , V. Afanas'eA. Orlova,
Movement Therapy (CIMT). Patients completed two weeks of CIMT,
and were scanned before and after training. For MRS a 2 × 2 × 2 cm
aI.M. Sechenov First Moscow State Medical University, Russia;
voxel was placed on the “hand knob” in the affected hemisphere of
bThe Russian National Research Medical University named after N.I.
the patients and in the dominant hemisphere of the healthy subjects.
Pirogov, Russia; cRehabilitation Center for Handicapped “Preodolenie”,
GABA was expressed as a ratio to Creatine (Cr). Motor function was
measured using the Wolf Motor Function Test (WMFT).
Results: GABA/Cr was signiﬁcantly lower (p b 0.001) in patients (0.33)
Objective: To evaluate the prevalence of asthenic syndrome in patients
at baseline compared to healthy subjects (0.42). After therapy, patients
with different general medical conditions and neurologic disorders.
showed a signiﬁcant improvement in hand function (p b 0.001),
Patients and methods: 171 patients with different peripheral nervous
which was negatively correlated with GABA/Cr changes (R = −0.57,
system disorders receiving inpatient treatment at hospitals were
p = 0.015) — larger improvements in patients were associated with
included (mean age 36.9 ± 8.1 years). Screening revealed the presence
greater reductions in GABA/Cr. Results were also signiﬁcant after
of asthenoneurotic syndrome (ANS) of different severity in 120 patients
correcting for changes in intracortical grey matter volume.
(70.6%) aged 25–56 years. To evaluate the dynamics of ANS complex
Conclusion: A decrease in GABA levels appears to facilitate motor
monitoring was performed on days 1 and 25, including analysis of
recovery after stroke. GABA, as measured non-invasively with MRS,
complaints, assessment of physical and neurologic status, and electro-
could be a biomarker for neuronal plasticity during recovery and
encephalography (EEG-neurokartograf MBN-20). The intervention
group received conventional therapy plus energocorrector and antiox-idant antihypoxant cytoﬂavin (n = 63) 2 tabs twice a day for 25 days.
The control group received conventional therapy plus placebo (n = 108)according to the same regimen.
Results: 28.1% of the patients with ANS demonstrated marked personality
accentuation with anxiety and excitable traits. At day 25 in the interven-
tion group 44.4% of the patients demonstrated no asthenic symptoms,
31.8%—only mild symptoms, 15.9%—moderate symptoms and 7.9%—
Amantadine treatment of aphasia after stroke
severe symptoms (р b 0.001). The control group showed an insigniﬁcantimprovement (р = 0.257). There was a positive trend in the subscales
K. Severinsen, A. Pedersen. Neurology, Hammel Neurorehabilitation
“anxiety” and “depression” with a strong correlation with asthenia
and Research Centre, Aarhus University, Hammel, Denmark
reduction in the intervention group (r N 0.5; р b 0.05). There was also animprovement in EEG indices—an increase in α-rhythm from 23% to 46% at
Background: Amantadine hydrochloride has been used as a central
day 25 in the intervention group (p b 0.05). Overall improvement was
stimulating pharmacological agent for treatment of disordered
registered in 88.9% of the patients, in the control group—27.8% (p b 0.05).
consciousness in patients with traumatic injury, but not for stroke
Conclusion: Energocorrection therapy in ANS results in a signiﬁcant
patients suffering from aphasia and other cognitive deﬁcits in the
decrease in asthenic and neurotic symptoms.
domains of execution, attention and processing speed.
Objective: To evaluate the effect of short term amantadine treatment
on aphasia in subacute stroke patients suffering from aphasia andother cognitive deﬁcits in the domains of execution, attention andprocessing speed.
Materials and methods: Nine subacute stroke patients (age 30–
69 years, time since onset 32–150 days) suffering from aphasia and
various other stroke sequelae, receiving inpatient neuro-rehabilita-
Power effective electrical stimulation of frog's
tion, completed the cohort study. No blinding was attempted and the
tibial-gastrocnemius preparation for 200-s continuous
intervention was not placebo controlled. Participants were treated
with amantadine (50 mg × 2 on days 1–2 and 100 mg × 2 on days
W.-Y. Ho, H. van der Merwe, Y.-K. Huang, F.-S. Jaw. Institute of
3–7) in order to ameliorate cognitive deﬁcits. Participants were
Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ROC
evaluated for changes in the severity of aphasia by application of theWestern Aphasia Battery (WAB), the WAB Aphasia Quotient (WAB-AQ)
Background: Electrical nerve stimulation (ENS) is not widely adopted
in clinical therapy due to a lack of standard and veriﬁcation of efﬁcacy.
Results: Amantadine treatment improved the verbal performance as
A previous study shows that ENS is beneﬁcial to prevent atrophy.
measured by the WAB-AQ by 11 points (CI95%: 6.7; 15.3), p b 0.0001.
Nevertheless, nerve ﬁbrosis might occur if the pulse frequency exceeds
The verbal performance after the subsequent three days of amanta-
40 Hz. For effective standing, various muscles need to maximally
dine wash-out was decreased by 5.1 (0.6; 9.6), p = 0.028 on the
contract for more than 200 s. Therefore, an ENS protocol should be
Conclusion: Treatment with amantadine seems to improve verbal
Materials and methods: The contraction force (CF) of the gastrocnemius
performance in patients suffering from aphasia after stroke. This is a
of frogs was measured and digitized for processing. An adjustable pulse
preliminary pilot trial and interpretation of the results must be made
was used to achieve a 200-s continuous maximum contraction (CMC)
with caution until further studies are performed.
with minimal power delivery. The maximum contraction force wasobtained by the interpolated twitch technique.
Results and discussion: Our data show that the best ENS protocolfor 200-s CMC is 8 Hz, 120 mV, and 35% duty cycle. Compared with
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ORAL SESSION July 7 (Wed), Hall A July 7(Wed) OPENING LECTURE 15:15-16:00 Moving Towards a New Era in the Research of Tonsil and Mucosal OL Barriers Dept. of Otolaryngology-Head and Neck Surgery, Infection and Immunity Research Center, Wakayama Medical University, Japan July 7(Wed) SYMPOSIUM 1. INNATE AND ADOPOSAL IMMUNOLOGY Chairpersons: David Nadal (Switzerland