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Patient information leaflet
PACKAGE LEAFLET: INFORMATION FOR THE USER
Retin-A® gel 0.01%
Retin-A® gel 0.025%
Retin-A is a registered trademark
Read all of this leaflet carefully before you start using this medicine.
Keep this leaflet. You may need to read it again If you have any further questions, ask your doctor or pharmacist This medicine has been prescribed for you. Do not pass it on to others. It
may harm them, even if their symptoms are the same as yours
If you get side effects and they become serious or if you notice any side
effects not listed in this leaflet, please tell your doctor or pharmacist
In this leaflet
What Retin-A is and what it is used for 2.
Before you use Retin-A 3.
How to use Retin-A 4.
Possible side effects 5.
How to store Retin-A 6.
Further information 1. What Retin-A is and what it is used for
The name of your medicine is Retin-A gel. It is cal ed ‘Retin-A’ in this leaflet.
Retin-A contains a medicine called tretinoin. This is similar to Vitamin A.
Retin-A is used to treat acne (also called acne vulgaris) and is for use in people
with oily skin.
It will normally take 6 to 8 weeks for your skin to improve. This means you will
need to be patient. 2. Before you use Retin-A
Do not use Retin-A if:
You are allergic to anything in Retin-A gel (listed in section 6 below) You have ever had a tumour of the top layer of your skin, or if this condition
You have inflamed, red, dry and scaly skin (eczema) You have a skin problem which can cause redness on the cheeks, nose,
The skin around your mouth is irritated (peri-oral dermatitis) You have sunburn or skin irritation with redness, peeling or itching. Your skin
will need time to recover from this before you start using Retin-A
You have been using a skin peeling agent (which removes the top layers of
your skin). Your skin will need time to recover before you start using Retin-A
Do not use this medicine if any of the above apply to you. If you are not sure,
talk to your doctor or pharmacist before using Retin-A. Using other skin products
You should not use harsh (astringent) or rough (exfoliating) cosmetic
products while using Retin-A. This includes skin peeling agents (which remove the top layers of the skin) or products that contain alcohol. It also includes products which have a strong drying effect on your skin (such as some face masks, cleansers or toners)
You may use ordinary make-up or moisturisers but do not apply them at the
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any
other medicines. This includes medicines that you buy without a prescription or
herbal medicines. This is because Retin-A can affect the way some other
medicines work. Also some other medicines can affect the way Retin-A works.
Pregnancy and breast-feeding
Do not use this medicine if you are pregnant, think you may be pregnant or
might become pregnant. This is because it may affect the baby.
Talk to your doctor before using this medicine if you are breast-feeding.
Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or breast-feeding.
Important information about some of the ingredients of Retin-A
Retin-A gel contains butylated hydroxytoluene (E321). This can irritate your
eyes, eyelids, mouth and nostrils if it comes into contact with them
3. How to use Retin-A
Always use Retin-A exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
How much to use
Normally you start by using Retin-A once or twice a day When your skin has improved your doctor may suggest that you use it less
often. It may take 6 to 8 weeks of treatment before your skin improves
Preparing your skin
Before applying Retin-A:
Wash your skin thoroughly with a mild soap Dry your skin without rubbing Do not wash treated skin more than twice a day
How and where to use
You only need to apply a small amount Lightly cover the affected areas of your skin Use cotton wool or the tips of clean fingers Do not let too much of this medicine collect in folds of the skin, such as
Do not use any Retin-A on cracked or weeping skin (such as eczema)
Do not use any Retin-A on your eyes, eyelids, nostrils or mouth (mucous
membranes). If it goes into any of these areas, wash them with water
Protection from the sun, cold or wind
Avoid being in the sun for too long while you are using Retin-A. Do not use
sunlamps or sunbeds while you are using Retin-A.
Use a sunscreen lotion with a sun protection factor (SPF) of at least 15 Wear a broad-rimmed hat Wear loose cotton clothes that will protect treated areas of your skin from the
While using Retin-A, you may also get some skin irritation in very cold or windy weather.
If you use too much Retin-A
Do not use too much of this medicine. Your skin will not improve any faster.
If you use too much Retin-A your skin might go red. It may also peel and feel
uncomfortable. If this happens, stop using Retin-A until all these symptoms have
If you swallow Retin-A
Only use Retin-A on the skin. If any is swallowed talk to a doctor or go to the
nearest hospital casualty department straight away.
If you have any further questions on the use of this product, ask your doctor or
4. Possible side effects
Like all medicines, Retin-A can cause side effects, although not everybody gets them.
Stop using Retin-A and tell your doctor straight away if you notice any of
the following serious side effects. You may need medical treatment.
Severe irritation or reddening of your skin, or other signs of allergy during the
first few days of treatment. This only happens in a small number of people
Blistering or crusting skin A burning feeling on the skin or swollen skin Your eye or eyes become swollen or irritated
If you get any of the above, stop using this medicine and tell your doctor straight away.
The side effects listed below usually go away as treatment continues.
Dry or peeling skin. This may go on for longer than the other side effects in
Warm skin or skin which stings Itchy or red skin, or a skin rash Light or dark patches on your skin
If any of the above are severe or last for a long time, talk to your doctor or pharmacist.
It is not known whether using Retin-A can increase the risk of skin tumours caused by sunlight.
If you get side effects and they become serious or if you notice any other side
effects not listed in this leaflet, please tell your doctor or pharmacist.
5. How to store Retin-A
Keep out of the reach and sight of children. Do not store above 25°C.
Do not use Retin-A after the expiry date which is stated on the label. The expiry date refers to the last day of that month.
Do not use the Retin-A if you notice that the tube seal is broken or missing.
Medicines should not be disposed of via wastewater or household waste. Ask
your pharmacist how to dispose of medicines no longer required. These
measures will help protect the environment.
6. Further information
The active substance
in Retin-A is tretinoin. Retin-A gel contains either 0.01%
or 0.025% of tretinoin.
The other ingredients
are butylated hydroxytoluene (E321), hydroxypropyl
cellulose (E463) and undenatured ethanol.
What Retin-A looks like and contents of the pack
Retin-A gel (both strengths) is a 60 g aluminium tube containing a clear yellow
The product licence is held by:
JANSSEN-CILAG LTD, 50-100 Holmers Farm Way, High Wycombe,
Buckinghamshire HP12 4EG, UK
Retin-A is made by:
Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium For information in large print, tape, CD or Braille, telephone
This leaflet was last approved in March 2010.
Landesarbeitsgemeinschaft Gesundheit und Soziales NRW Protokoll LAG Gesundheit und Soziales Termin: Samstag,22.09.2012.2012 11:00 – 16:30 UhrOrt: LINKES Zentrum Oberhausen, Elsässer Str. 19, 46045 Oberhausen Teilnehmer/innen Vili Baßnik , Elke Eisenburger, Peter Esser, Rolf Fahnenbruck , Sylvia von Höfen, Rolf Kohn, Werner Rejek, Gast: Angela Spelsberg, Vorstandsmitglied bei Tran
Senior Research Scientist Gilead Education 1984: B.S., Physical Chemistry, Department of Chemistry, Xiamen University, Xiamen, Fujian, P.R. China. Ph.D. in Biophysics/Physical Chemistry with Prof. Robert C. Matthews, Department of Chemistry, the Pennsylvania State University, USA Postdoctoral Fellow with Prof. Fred Cohen, Department of Pharmaceutical Chemistry, University of Californ