The Hormone Puzzle Increase Risk of Breast Cancer Protection Strategy Excessive Strong Estrogens (Estradiol E1 Increase Estriol E3 (Weak estrogen) with: Decrease Estradiol E1 and Estrone E2
Improve liver detoxification & elimination Stall puberty Sleep in a dark room
Increased C4 and C16 Estrogens linked
Make more C2 Estrogen, Less C4 and C16; Inactivate C4 Estrogen with:
1. Promote formation of C2 estrogens:
2. Assist Liver Detoxification:
cysteine, taurine MSM betaine Vitamins B6, B12, B2, folic acid, choline Minerals – magnesium, selenium, zinc Calcium-D-glucarate Milk thistle, curcumin, ellagic acid
Increase Risk of Breast Cancer Protection Strategy
● Helen Papaconstantinos, RNCP, ROHP, BA (Hons) 416-454-0131
3. Dietary – low fat diet, EPA (fish
oil), ground flax seeds, increased fibre, wheat bran, psyllium, probiotics, red clover, phytoestrogens - 8 to 10 servings of vegetables; 2 servings of fruit; 1 serving of complex carbohydrates (that means whole grains like brown rice, millet, quinoa, oats and whole wheat flours like spelt and kamut); 1 serving of protein (preferably nut and vegetable protein)
4. Normalize progesterone Increased Production of Strong Inhibit Aromataze with: Estrogens (Estradiol and Estrone) due to:
Ground flaxseed (moderate) Genistein (soy) (weak) Zinc
Decreased SHBG (Sex Hormone Binding Increase SHBG with:
Normalize cortisol, insulin, IGF-1, testosterone
Increased Number of Estrogen Decrease Number of Estrogen Receptors Receptors due to:
Xenoestrogens Hormone replacement therapy High Body Mass index
Xenoestrogens Attach to Estrogen Block Estrogen Receptors with: Receptors such as:
● Helen Papaconstantinos, RNCP, ROHP, BA (Hons) 416-454-0131
Increase Risk of Breast Cancer Protection Strategy Decreased Progesterone due to: Increase Progesterone with:
Normalize thyroid, use zinc, seaweed, selenium to increase T3
High Prolactin due to: Normalize Prolactin with: Elevated Testosterone due to: Normalize Testosterone with: Increased Growth Hormone due to: Normalize Growth Hormone with:
● Helen Papaconstantinos, RNCP, ROHP, BA (Hons) 416-454-0131
Increase Risk of Breast Cancer Protection Strategy Low Thyroid (Hypothyroid) Function Normalize Thyroid Function with: Increase Conversion of T4 to T3 with:
Tyrosine, cysteine, iodine Zinc, selenium, copper Vitamin B12 Flaxseed Oil
High Thyroid (Hyperthyroid) Function Normalize Thyroid Function with:
Magnesium, Vitamin B complex Avoid radiation
High Insulin Levels due to : Normalize Insulin Levels with:
Maintain ideal weight Chromium, magnesium, niacin Alpha lipoic acid Flax or fish oil
Increased IGF-1 due to: Lower IGF-1 with: Increase Risk of Breast Cancer Protection Strategy
● Helen Papaconstantinos, RNCP, ROHP, BA (Hons) 416-454-0131
High Cortisol Levels due to: Normalize Cortisol Levels with:
Increased testosterone Decreased efficiency of thyroid hormone Decreased melatonin production
Decreased Melatonin due to: Increase Melatonin using:
in a.m. Exercise daily Normalize cortisol
Many thanks for this wonderful resource, adapted from:
The Complete Natural Medicine Guide to Breast Cancer,
● Helen Papaconstantinos, RNCP, ROHP, BA (Hons) 416-454-0131
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The Hormone Puzzle 
3. Dietary – low fat diet, EPA (fish 
Increase Risk of Breast Cancer 
Increase Risk of Breast Cancer 
High Cortisol Levels due to: