La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.

Signs of neuromuscular disorders that must not be missed

NeuroFlash
NeuroFlash 1
Neurotoxicology
NeuroFlash 2
Neurologic disease in women
• WHIMS (estrogen or estrogen/progest) NeuroFlash 3
Women and epilepsy
NeuroFlash 4
Neuro-oncology
NeuroFlash 5
Advances in Neurosurgery
• Microdialysis – cerebral metabolism NeuroFlash 6
Neurology and the Military
NeuroFlash 7
Lifestyle factors in Alzheimers Disease
NeuroFlash 8
Epilepsy
• Failure of adequate trials of 2 tolerated and • Epilepsy Surgery seizure free (1 year) NeuroFlash 9
Drug Induced Reversible Encephalopathy
• Tacrolimus, cyclosporine, sirolimus, MTX, interferom, rituximab, bevacizumab, sorafenib, sunitinib, fingolimod, IVIG • Cyclophosphamide, cytarabine, doxorubicin, etoposide, • Cocaine, ampetamines, TCA, SSRI, midodine, fludrocostisone NeuroFlash 10
Neurologic Heavy Metal Disorders
NeuroFlash 11
Neurologic Autoimmune Encephalitis
• HA, fever, behavior change, psychosis, movement disorder, NeuroFlash 12
Sleep disorders in children
• Down syndrome, muscular dystrophy, Prader-Willi

Source: http://www.geisinger.edu/Residencies/neurology/pdf/NeuroFlash_Hosey.pdf

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