La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.
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Volume 373 · Number 9671 · April 11–17, 2009 The Lancet—London Editorial Articles
1253 Zoledronic acid and risedronate in the prevention and
1224 Care for vulnerable migrants in the UK
treatment of glucocorticoid-induced osteoporosis
double-dummy, randomised controlled trial
The Lancet—New York
1225 Glucocorticoid-induced osteoporosis: hope on the
1264 Prophylactic administration of avotermin for
improvement of skin scarring: three double-blind,
1226 Wound healing: from embryos to adults and back
1275 Catheter-based renal sympathetic denervation for
resistant hypertension: a multicentre safety and
1228 Interventional management of resistant hypertension
1230 Gender inequality and fire-related deaths in India
1282 Fire-related deaths in India in 2001: a retrospective
1231 Serial offending: evaluation of drugs courts
1233 The HRT controversy: observational studies and RCTs
1289 Arrhythmogenic right ventricular cardiomyopathy
Deputy Editor Senior Executive Editor
1235 Sirolimus to replace calcineurin inhibitors? Too early
Executive Editors World Report Case Report
1237 The USA shifts away from the “war on drugs”
Managing Editor Stephanie Clark Web Editors Perspectives Senior Editors
Jane Godsland Seema Kang
1243 Hongjie Yu: monitoring avian influenza in China
1244 Vulnerability and ethics: considering our Cartesian
Conference Editor North American Senior Editor Maja Zecevic (New York) Obituary Senior Assistant Editors Hannah Cumber Correspondence Assistant Editors Tamara Barrett J S Earle; G Tamburlini, A Cattaneo; D Stuckler and others
Farhat Yaqub Editorial Researcher
1248 Are new drugs for schizophrenia better than old ones?
P Gøtzsche; I Anghelescu, M Dettling; S Jauhar and others; S Leucht and othersPR and Press Officer
Peer reviewed and fast-tracked to publication in 4 weeks
B Mathews, H Payne; R Gilbert and othersEditorial Assistant
1251 The UK’s NHS and pharma: need for more clinical
Web Content Coordinator
See www.thelancet.com for WebExtra content
1252 Inequalities in the American health-care system
International Advisory Board Information for Authors
1252 Department of Error Ombudsman
Convergent Software & ISO 28560-2 Conformance Document The bit and byte ordering discussed in the ISO 28560-2 Guidelines for development of ISO 28560-2 conformant devices (direct link: http://biblstandard.dk/rfid/docs/conformance_28560-2.pdf) explains that there is a complex relationship between the various components between the application (for example the Library Management System)
Phytoestrogens in Soy-Based Infant Foods: Concentrations, Daily Intake and Possible Biological Effects C.H.G. Irvine, M.G. Fitzpatrick† and S.L. Alexander Animal and Veterinary Sciences Group, Lincoln University, New Zealand, and † Chemistry Department, University of Auckland, Auckland, New Zealand Corresponding author : Prof C.H.G. Irvine, Animal & Veterinary Sciences Group,
Volume 373 · Number 9671 · April 11–17, 2009