La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.

Publ eng 2003-10.doc

PUBLICATIONS
ARTICLES
1. Olsson OAT, Ahlquist B, Gustafsson B. A new β2-adrenoceptor agonist with α1- adrenoceptor blocking properties. Acta Pharmacol Toxicol 1981;48:340-8. 2. Olsson OAT, Ahlquist B, Gustafsson B, Persson G. The effects in myometrial preparations of D2343, a β2-adrenoceptoragonist possessing α1-receptor blocking qualities. Acta Pharmacol Toxicol 1984;55:391-397. 3. Olsson OAT, Gustafsson B. The effect of D2343 in transmurally stimulated rabbit isthmus muscle. Acta Pharmacol Toxicol 1985;56:427-430. 4. Gustafsson B, Persson CGA. In vitro interactions between xanthines and β-receptor agonists in trachea and the heart. In: Current Clinical Practice Series No. 19. Anti-asthma xanthines and adenosine. Proceedings of a symposium in Copenhagen, Feb 22-23, 1985. Eds. Andersson K-E, Persson CG. 1985;214-9. 5. Persson CGA, Gustafsson B, Kjellin G. Tracheal relaxation and adenosine antagonism by 1- and/or 3-alkylxanthines. In: Current Clinical Practice Series No. 19. Anti-asthma xanthines and adenosine. Proceedings of a symposium in Copenhagen, Feb 22-23, 1985. Eds. K-E Andersson and CGA Persson. 1985;447-452. 6. Persson CGA, Gustafsson B. Tracheal relaxation from combinations of xanthines and of a β2-receptor agonist and xanthines. Lung 1986;164:33-40. 7. Persson CGA, Erjefält I, Gustafsson B. Xanthines - symptomatic or prophylactic in asthma? Agents Actions Suppl. Directions for new anti-asthma drugs. 1988;23:137-55. 8. Persson CGA, Andersson PT, Gustafsson B. Budesonide reduces sensitivity to antigen but does not alter baseline tone or responsiveness to carbachol, terbutaline, and enprofylline in IgE-sensitized guinea-pig tracheae. Int Arch Allergy Appl Immunol 1989;88:381-5. 9. Gustafsson B, Persson CGA. Effect of three weeks´ treatment with budesonide on in vitro contractile and relaxant airway effects in the rat. Thorax 1989;44:24-7. 10. Persson CGA, Erjefält I, Gustafsson B, Luts A. Subepithelial hydrostatic pressure may regulate plasma exudation across the mucosa. Int Arch Allergy Appl Immunol 1990;92:2:148-153. 11. Gustafsson GB, Persson CGA. Asymmetrical effects of increase in hydrostatic pressure on macromolecular movement across the airway mucosa. Clin Exp Allergy 1991;21;1:121-126. 12. Persson CGA, Erjefält I, Alkner U, Baumgarten C, Greiff L, Gustafsson B, Lets A, Pipkorn U, Sundler F, Svensson C, Wollmer P. Plasma exudation/transudation as a first line mucosal defence. Clin Exp Allergy 1991;21:1:17-24. 13. Gustafsson B, Persson CGA. Effect of different bronchodilators on airway smooth muscle responsiveness to contractile agents. Thorax 1991;46:360-365. 14. Persson CGA, Gustafsson B, Luts A, Sundler F, Erjefält I. Toluene diisocyanate produces an increase in airway tone that outlasts the inflammatory exudation phase. Clin Exp Allergy 1991;21;6:715-724. 15. Gustafsson B, Persson CGA. Allergen-induced mucosal exudation into rat distal ileum and its inhibition by budesonide. Scand J Gastoenterol. 1992;27:587-593. 16. Persson CGA, Gustafsson B, Erjefält JS, Sundler F. Mucosal exudation of plasma is a non-injurious intestinal defence mechanism. Allergy Eur J Allergy Clin Immunol 1993;48:581-586. 17. Persson CGA, Greiff L, Andersson M, Erjefält I, Svensson C, Alkner U, Gustafsson B. Mucosal exudation of plasma in asthma and rhinitis. In: Asthma and Rhinitis. Eds. Busse WW, Holgate ST. Blackwell Scientific Publications. 1995; 733-741. 18. Persson CGA, Andersson M, Greiff L, Svensson C, Erjefält JS, Sundler F, Wollmer P, Alkner U, Erjefält I, Gustafsson B, Linden M, Nilsson M. Airway permeability. Clin Exp Allergy 1995;23:807-814. 19. Miller-Larsson A, Gustafsson B, Brattsand R, Persson CGA. Upptag och retention av steroider i ileum hos råtta. Gastro Focus 1995;5:26. 20. Erjefält JS, Andersson P, Gustafsson B et al. Allergen challenge-induced extravasation of plasma proteins in mouse airways. Clin Exp Allergy 1998;28:1013-1020. 21. Gustafsson B, Miller-Larsson A, Persson CGA. Topical and oral anti-inflammatory activity of budesonide compared with prednisolone, using allergen-induced gut mucosal exudation of plasma as a marker. Scand J Gastroenterol 2001;36:1062-1066. 22. Miller-Larsson A/Gustafsson B, Persson CGA, Brattsand R. Gut mucosal uptake and retention characteristics contribute to the high intestinal selectivity of budesonide compared with prednisolone in the rat. Aliment Pharmacol Ther 2001;15(12):2019-2025. ABSTRACTS
1. Olsson OAT, Ahlquist B, Gustafsson B. A β2-adrenoceptor agonist with α1-adrenoceptor blocking properties. Acta Pharmacol Toxicol 1981;49:83 [Abstract]. 2. Finney MJ, Gustafsson B, Karlsson JA, Persson CGA, Sonmark B. Effects of terbutaline, theophylline and enprofylline in tracheas, bronchi and lung strips contracted by proposed asthma mediators. Br J Pharmacol 1983;80:710P [Abstract]. 3. Gustafsson B, Erjefält I, Luts A, Persson CGA. Hydrostatiskt tryck subepitelialt ger atraumatiskt och reversibelt inträde av plasma i luftvägslumen. XVII Nordiska kongressen i allergologi, 1990 [Abstract]. 4. Persson CGA, Gustafsson B. Allergen-induced plasma exudation into the gut. Clin Exp Allergy Eur J Allergy Clin Immunol 1992;22;1:130(P30) [Abstract]. 5. Gustafsson B, Persson CGA. Allergen-induced mucosal exudation of plasma into rat ileum and its inhibition by budesonide. Allergy Eur J Allergy Clin Immunol 1992;12;47:247 [Abstract]. 6. Gustafsson B, Erjefält JS, Sundler F, Persson CGA. Exudation of plasma across an intact mucosa in gut allergy. Allergy Eur J Allergy Clin Immunol 1993;48;15(Suppl):89 [Abstract]. 7. Persson C, Andersson M, Greiff L, Svensson C, Åkerlund A, Alkner U, Erjefält I, Gustafsson B, Linden M, Wollmer P, Erjefält J, Sundler F. Inflammatory responses of mucosal end-organs. Allergy Eur J Allergy Clin Immunol 1993;48;15(Suppl):19 [Abstract]. 8. Gustafsson B, Erjefält JS, Sundler F, Persson CGA. Exudation of plasma across an intact mucosa in gut allergy and its inhibition by glucocorticoids. Falk Symposium Series no 72, 1993 [Abstract]. 9. Gustafsson B, Persson CGA. Oral budesonide exhibits greater topical selectivity than prednisolone in a rat ileal inflammation model. Gastroenterology 1994;106;4(2):A696 10. Persson CGA, Gustafsson B. Absorption- and exudation-permeability across the gut mucosa in vivo. Differential actions of allergen and acetic acid. Gastroenterology 1994;106;4(2):A752 [Abstract]. 11. Miller-Larsson A, Gustafsson B, Brattsand R, Persson CGA. Mucosal and submucosal ileal uptake of topical budesonide in absence and presence of inflammatory exudation of plasma. Gastroenterology 1994;106;4(2):A735 [Abstract]. 12. Gustafsson B, Persson CGA. Budesonide has a greater topical selectivity than prednisolone in rat allergic ileum. Allergy Clin Immunol News 1994;6(Suppl 2):340 [Abstract]. 13. Persson CGA, Gustafsson B. Absorption- and exudation-permeability of rat ileal mucosa in vivo. Differential actions of allergen and acetic acid. Allergy Clin Immunol News 1994;6;2:340 [Abstract]. 14. Gustafsson B, Miller-Larsson A, Brattsand R, Persson CGA. Onset of action and topical antiinflammatory efficacy of budesonide in allergen challenged rat ileum. Gastroenterology 1995;108;4:A830 [Abstract]. 15. Miller-Larsson A, Gustafsson B, Brattsand R, Persson CGA. Mucosal uptake and retention of steroids in rat ileum. Possible explanation of topical efficacy in inflammatory bowel diseases (IBD). Gastroenterology 1995;108;4:A876 [Abstract]. 16. KAL Lundblad, B Gustafsson, U Johansson, P Ottosson, PT Persson, C Brange, C Zackrisson. Airways hyperreactivity does not correlate with morphometry in allergic mice. Resp Crit Care Med 1999; 159(3): A408 [Abstract]. 17. Miller-Larsson A, Gustafsson B, Hjertberg E, Persson CGA, Brattsand R. Reversible formation of lipophilic fatty acid esters of the glucocorticoid budesonide in rat ileal tissue in vivo. Gut 2001;49(Suppl III)[Abstract]. 18. Miller-Larsson A, Gustafsson B, Jerre A, Wieslander E, Brattsand R. Intestinal esterification of budesonide may prolong glucocorticoid activity. Gastroenterology 2002;122;4:A396 [Abstract].

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