La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.

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Chin Ho sp Pharm J ,2005 Aug ,Vol 25 ,No . 8 Allen R , Myers A R , Frederick H , et al . The relatio nship of ser2 um uric acid to risk facto rs in co ro nary heart disease [ J ] . Am J Puig J G , Mat eo s F , Bo un A , et al . Effect of Ep ro sartan and Lo sartan o n uric acid met aboli sm in patient s wit h essential hyper2 tensio n[J ] . Hypertens , 1999 , 17 (7) : 1033 Edwareds RW , Triznaw , stack EJ . Interoctio n of no npeptide an2 recepto r antagonist s wit h t he urat e t ranspo rer inrat renal brush bo rder membranes [ J ] . Pharmacol Exp Ther , 1996 , Preparation and i n vit ro studies on diclofenac sodium patch
YU Co ng2ho ng1 ,2 ,SON G Jin2chun1 ,2 ,WAN G Yu2guang2 ,ZEN G J un2fen2 (1. The Pepole s Hospital of Wuhan Universi2 t y , Hubei Wuhan 430060 ,China ;2 . The Pharmacy College of Wuhan U niversit y , Hubei Wuhan 430072 ,China) ABSTRACT :OBJECTIVE
To p repare t he diclofenac sodium patch and st udy it s characteristics of t ransdermal delivery. METHODS
Met hacrylic acid copolymer was employed to p repare declofenac so dium patch. Snake skin and mo dified Franz diff usio n cell s were used in t he drug penet ratio n test s. The release test was perfo rmed using t he met hod of t he Chinese p harmacopoeia. RESUL TS
release rate of diclofenac sodium patch was 21 . 98 g cm - 2 h - 1/ 2 ,t he penet ratio n rate in vit ro was 17 . 97 g cm - 2 h - 1/ 2 . CONCL U2
The release rate and t he penet ratio n i n vit ro of diclofenac sodium patch acco rded wit h t he Higuchi equatio n. Diclofenac sodi2 KEY WORDS :diclofenac so dium ; release rate ; i n vit ro permeatio n
Chin Ho sp Pharm J ,2005 Aug ,Vol 25 ,No . 8 10 - 5 A + 0 . 059 8 , r = 0 . 999 9 , Release test s of DCF2T TS( g cm - 2 , n = 6) Penet ratio n test s of DCF - T TS ( x : M = 3 . 98 t + 169 . 90 , r = 0 . 989 3 : M = 21 . 98 t1/ 2 + 140 . 67 , r = 17 . 97 t1/ 2 - 28 . 32 , r = 0 . 999 7 ( n = 7 ) Chin Ho sp Pharm J ,2005 Aug ,Vol 25 ,No . 8 The preparation and the qual ity assessment of cetirizine gel
C H EN Teng ,L I Shi2gen , SU Xi2tan ( Guangdong Provincial Corp s Hospital , Chinese People s Armed Police Forces , Guangdo ng Guangzho u 510507 ,China ) ABSTRACT :OBJECTIVE
To p repare cetirizine gel and establish a qualit y co nt rol met ho d fo r t he gel. METHODS
was used t he gel base ,t he co ntent of cetirizine was determined wit h UV2spectrop hotomet ry and t he stability test was performed. RE2
There was a good linearit y of calibratio n curve of cetirizine in range of 6216 mg L - 1 , r = 0. 996 7 ,t he average recovery was 98 . 23 %. RSD was 0 . 69 % ( n = 5) The gel was stable. CONCL USION
The design of t he gel fo rmulatio n is reaso nable. The gel can be p repared feasibly and is stable in qualit y ,co nvenient in use.
KEY WORDS :cetirizine ;gel ;p reparatio n ;qualit y assessment
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