Safety data sheet

SIGMA-ALDRICH
sigma-aldrich.com
Material Safety Data Sheet

1. PRODUCT AND COMPANY IDENTIFICATION
both supplier and manufacturer) Preparation Information Product Safety - Americas Region 1-800-521-8956
2. HAZARDS IDENTIFICATION
Emergency Overview
WHMIS Classification
GHS Classification
Acute toxicity, Oral (Category 3)
GHS Label elements, including precautionary statements
IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. HMIS Classification
Health hazard:
Flammability:
Physical hazards:
Potential Health Effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. Ingestion

3. COMPOSITION/INFORMATION ON INGREDIENTS
Sigma - A7410
: N-Amidino-3,5-diamino-6-chloropyrazinecarboxamidehydrochloride Amiloride hydrochloride hydrate
no data available

4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

5. FIRE-FIGHTING MEASURES
Conditions of flammability
Not flammable or combustible.
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.
Hazardous combustion products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx), Hydrogen
chloride gas
Explosion data - sensitivity to mechanical impact
no data available
Explosion data - sensitivity to static discharge
no data available

6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for
disposal.

7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Sigma - A7410
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Contains no substances with occupational exposure limit values. Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99
(US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching
glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in
accordance with applicable laws and good laboratory practices. Wash and dry hands.
Eye protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
Specific engineering controls
Use mechanical exhaust or laboratory fumehood to avoid exposure.

9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Safety data
Sigma - A7410

10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Materials to avoid
Strong oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx), Hydrogen
chloride gas
Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION
Acute toxicity
Oral LD50
no data available
Inhalation LC50
no data available
Dermal LD50
no data available
Other information on acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. Reproductive toxicity
Teratogenicity
Sigma - A7410
Specific target organ toxicity - single exposure (Globally Harmonized System)
no data available
Specific target organ toxicity - repeated exposure (Globally Harmonized System)
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation. Ingestion
May be harmful if absorbed through skin. May cause skin irritation. Signs and Symptoms of Exposure
Nausea, Vomiting, Diarrhoea, Constipation., Paresthesia., Dizziness, Rash, Weakness
Synergistic effects
no data available
Additional Information
RTECS: Not available

12. ECOLOGICAL INFORMATION
Toxicity
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects

13. DISPOSAL CONSIDERATIONS
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste
disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a
chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION
DOT (US)
UN-Number: 2811 Class: 6.1
Proper shipping name: Toxic solids, organic, n.o.s. (Amiloride hydrochloride hydrate)
Marine pollutant: No
Poison Inhalation Hazard: No
IMDG
UN-Number: 2811 Class: 6.1
Sigma - A7410
Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (Amiloride hydrochloride hydrate)
Marine pollutant: No
IATA
UN-Number: 2811 Class: 6.1
Proper shipping name: Toxic solid, organic, n.o.s. (Amiloride hydrochloride hydrate)
15. REGULATORY INFORMATION
DSL Status
This product contains the following components that are not on the Canadian DSL nor NDSL lists.
WHMIS Classification
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all the information required by the Controlled Products Regulations.
16. OTHER INFORMATION
Further information
Copyright 2011 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with the
above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.
Sigma - A7410

Source: http://apps.mni.mcgill.ca/icrcl/secpss/members/docs/Amiloride_2016_88_8.pdf