La tétracycline, connue sous le nom commercial Sumycin, agit en bloquant la fixation de l’ARNt sur la sous-unité 30S ribosomale, interrompant l’élongation de la chaîne protéique bactérienne. Ce mécanisme confère une activité sur un spectre large, incluant bactéries Gram positives, Gram négatives, rickettsies et spirochètes. Sa biodisponibilité digestive varie selon la prise alimentaire et les interactions avec les ions divalents comme calcium et magnésium. Sa diffusion tissulaire est importante, notamment dans les voies respiratoires et génito-urinaires. L’élimination se fait par voie rénale et biliaire. Les effets indésirables incluent photosensibilisation, troubles digestifs et coloration dentaire en cas d’administration précoce. Les guides thérapeutiques mentionnent sumycin prix, en soulignant la nécessité de restreindre son utilisation afin de limiter les résistances acquises.

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Takeda leads the way on skills
Founded in 1781 and headquartered in Osaka, Japan,
Takeda Cambridge showed an early interest in working Takeda is a research-based global pharmaceutical with Cogent to develop a training framework for SMEs company. Worldwide, Takeda markets a number of and in the new Higher Apprenticeship in Life Sciences blockbuster drugs discovered through its internal programme. This has seen TCB take on their first ever research programmes including Actos®, Blopress®, and apprentice, an HA in life sciences (the first in the sector). Prevacid®. Takeda Cambridge Ltd (formerly Paradigm TCB has also joined the Cogent Life Sciences Skills Therapeutics) was established in 2000 by Cambridge University researchers. Using genetic models and in vivo pharmacology Takeda Cambridge (TCB) and Linda Millett, Head of Human Resources “Takeda
its subsidiary Takeda Singapore have developed a Cambridge is very pleased to be supporting the
promising pipeline of novel drug discovery projects.
important work of Cogent in developing training
frameworks for SMEs and identifying skills gaps in
The Cambridge site employs around 120 people with a the biosciences industry. We are delighted to be
further 30 researchers in Singapore. 90 per cent of the participating in the HA life sciences pilot scheme and
staff are biosciences graduates and the majority are to have our first apprentice start work in our in vitro
pharmacology department.”
TCB recognises the importance of maintaining a Natalie Webster, HA says “The Higher Apprenticeship
highly-skilled workforce at all levels. Typical scientific in Life Science provides a fantastic opportunity
training courses on offer include statistics and database to study in higher education as well as learning a
management. When Linda Millett, Head of Human range of laboratory based practical skills in a real
Resources, could not source a suitable course on Project life working environment. I have already had hands
Management for Scientists she decided to bring this on experience with compound screening in assay
in-house and is now developing this with a local training development, cell transfections, cloning, cell culture
and DNA purification. I have enjoyed every minute
so far at Takeda Cambridge and I’m confident I will
Linda has also recently launched a Training Curriculum continue to feel this way throughout the duration of
at TCB which focuses on “soft skills” for scientists my placement here.”
including, communication, presentation skills and management and supervisory training. TCB has a cultural awareness training course which is delivered as part of their induction programme and aims to raise awareness of cultural differences (both national and If you want
to find out more about
any of Cogent’s programmes
contact us on: 01925 515 200
www.cogent-ssc.com
Cogent SSC, Unit 5, Mandarin Court, Centre Park, Warrington WA1 1GG

Source: http://83-223-111-55.as29017.net/Publications/Case_studies/Takeda_Cambridge_Limited.pdf